Ubuvuzi bushya bwa Gene butanga icyizere gishya ku barwayi ba Sickle Cell na Thalassemia

Ubuvuzi bushya bwa Gene butanga icyizere gishya ku barwayi ba Sickle Cell na Thalassemia

Mu iterambere rikomeye ku barwayi barwaye indwara ya sickle cell (SCD) na thalassemia, uburyo bushya bwo kuvura gene burimo kugaragaza umusaruro utangaje. Ubu buryo bwo kuvura, bukoresha ikoranabuhanga rigezweho ryo guhindura gene rya CRISPR/Cas9, bwagaragaje ko bukira 100% mu igeragezwa ry’ubuvuzi, butanga icyizere gishya ku barwayi barwaye iyi ndwara ikomeye y’amaraso.

Ubu buvuzi, bwakozwe hifashishijwe urubuga rwa ModiHSC®, bugamije imizi ya SCD na thalassemia. Mu guhindura neza BCL11A enhancer mu turemangingo tw’amaraso y’umwana n’uturemangingo tw’amaraso, ubu buvuzi butuma umubiri ukora hemoglobine y’umwana (HbF) iri hejuru. Urugero rwa HbF rwinshi rwagaragaye ko rurwanya ingaruka mbi za hemoglobine y’umwana (HbS) kandi rugabanya ibimenyetso bya SCD na thalassemia, harimo no gukumira ibibazo byo mu miyoboro y’amaraso no kugabanya amaraso make mu maraso.

BIOOCUS, itsinda rikomeye mu bijyanye no kuvura indwara zishingiye ku ngirabuzima fatizo, ku bufatanye n'ibitaro bya Lu Daopei, yagize uruhare runini mu kugeza ubu buvuzi bushya ku barwayi. 

Intsinzi y’ubu buvuzi ni ntagereranywa, kugeza ubu abarwayi 15 bavuwe, bose bakaba barakize burundu kandi ubuzima bwabo bwarazamutse cyane. Iki gipimo cyo gukira 100% ni intambwe ikomeye mu kurwanya SCD na thalassemia.

Ubu buvuzi bwamenyekanye ku rwego mpuzamahanga, aho impuguke hirya no hino ku isi zibushimagiza nk'intambwe ikomeye mu kuvura indwara z'amaraso zishingiye ku maraso. Buragaragara cyane atari uko bufite akamaro gusa ahubwo no ku giciro gito. Bitandukanye n'ubundi buryo bwo kuvura bushingiye ku ngirabuzima fatizo, bushobora kuba buhenze cyane, ubu buvuzi butanga icyitegererezo cy'ibiciro byoroshye, bigatuma buba amahitamo meza ku barwayi benshi.

Mu rubanza rumwe rushishikaje, umurwayi w'imyaka 12 ufite ibibazo byo kuva amaraso mu mubiri we (vaso-occlusive crisis) byakomeje kugaragara ndetse no kubura amaraso mu mubiri we (hemolytic anemia) byamubujije kugaragara burundu nyuma yo kuvurwa n'ubu buryo bwo kuvura ibinyabuzima. Uru rubanza, mu zindi, rugaragaza ubushobozi bwo guhindura ubuvuzi ku barwayi ba SCD na thalassemia ku isi yose.

Mu gihe BIOOCUS ikomeje kwagura uburyo ubu buvuzi buboneka, harimo n'igeragezwa ry'ubuvuzi riri imbere mu Bushinwa, ahazaza hasa n'ahari icyizere ku bagizweho ingaruka n'izi ndwara zikomeye. Ku nkunga y'ibitaro bya Lu Daopei, ubu buvuzi bugiye kuvugurura uburyo bwo kwita ku ndwara za SCD na thalassemia, bugatanga ubuzima bushya ku barwayi batabarika.

Niba wowe cyangwa uwo ukunda arwaye indwara ya sickle cell cyangwa thalassemia kandi akaba ashishikajwe no gusuzuma ubu buryo bushya bwo kuvura, turagutumiye kutwandikira. Itsinda ryacu ryiteguye kuguha ubufasha n'amakuru ukeneye kugira ngo ufate ibyemezo bisobanutse neza ku rugendo rwawe rw'ubuvuzi.

Inkunga yuzuye ku barwayi mpuzamahanga bajya mu Bushinwa kuvurwa Hemo-cell

Muri BIOOCUS, twiyemeje gutanga ubuvuzi budasanzwe no gushyigikira abarwayi mpuzamahanga barwaye indwara ya thalassemia cyangwa se indwara ya sickle cell bashaka kuvurwa na hemo-cell mu Bushinwa. Serivisi zacu zirambuye zikubiyemo intambwe zose z'urugendo, kuva ku gutegura mbere y'urugendo kugeza ku buvuzi nyuma yo kuvurwa.

1. Imyiteguro mbere yo kujya mu rugendo

Mbere yo kugenda, abarwayi bazakorerwa isuzuma ryimbitse mu bitaro byabo. Ibi birimo gusuzuma amateka y’ubuzima bwabo, gukurikirana ibimenyetso by’ubuzima bwabo, gupima amaraso, no gusuzuma indwara ya thalassemia cyangwa sickle cell. Turareba neza ko inyandiko zose z’ubuvuzi, harimo n’inyandiko zo guterwa amaraso n’ibyemezo by’uko banduye, zakusanyijwe neza kandi zoherezwa mu kigo cyacu kugira ngo zisuzumwe.

2. Ingendo n'Ivuriro

Turoroshya inzira yose y'ingendo, harimo no gutegura uburyo bwo kwakira abarwayi mu bitaro byabugenewe. Abarwayi bayoborwa mu nzira yo kwakira abarwayi bakigera aho, bityo bigatuma habaho uburyo bwo kuvurwa mu buryo butajegajega.

3. Uburyo bwo kuvura

Nyuma yo kwakirwa, abarwayi bazakorerwa ibizamini by’ibanze. Nibaramuka bemerewe, hazatangira gukusanywa no gukusanya uturemangingo tw’amaraso. Utwo turemangingo twoherezwa mu kigo cyacu cya GMP kugira ngo tugenzure ubuziranenge kandi dukorerwe mu nganda, aho abarwayi bashobora gusubira mu gihugu cyabo kugira ngo bategereze andi mabwiriza.

4. Gutera no gukurikirana ubuvuzi

Iyo uturemangingo tw’umubiri twateguwe tumaze kwemezwa, abarwayi bazagaruka guterwa ubwoko bw’uturemangingo. Itsinda ryacu ryiyemeje gutanga ubufasha buhoraho mu gihe cyose cyo kwakirwa mu bitaro, rikareba ko buri murwayi abona ubuvuzi bwihariye. Nyuma yo kuva mu bitaro, duhuza ibizamini byo gukurikirana buri gihe kugira ngo dukurikirane gukira no kubaho neza.

Kuri BIOOCUS, dushyira imbere ubuzima n'ihumure ry'abarwayi bacu mpuzamahanga, dukora ibishoboka byose kugira ngo dutange uburambe bufatika kandi butanga ubufasha. Kubindi bisobanuro ku bijyanye na serivisi zacu, twandikire.