Kurapa Majini Kunopa Tariro Itsva kuVarwere veSickle Cell neThalassemia

Kurapa Majini Kunopa Tariro Itsva kuVarwere veSickle Cell neThalassemia

Mukuvandudzwa kukuru kwevarwere vane chirwere chesickle cell (SCD) uye thalassemia, kurapwa kwemajini matsva kuri kuratidza kubudirira kukuru. Kurapa uku, uko kunoshandisa tekinoroji yepamusoro yekugadzirisa majini yeCRISPR/Cas9, kwaratidza mwero wekurapa we100% mukuyedzwa kwekiriniki, zvichipa tariro itsva kune avo vari kurwisana nezvirwere izvi zvakakomba zveropa.

Kurapa uku, kwakagadzirwa nepuratifomu yeModiHSC®, kunotarisa midzi yemajini yeSCD nethalassemia. Nekugadzirisa nemazvo BCL11A enhancer mumasero eropa e autologous uye progenitor, kurapwa uku kunogonesa muviri kugadzira huwandu hwakakwira hwe fetal hemoglobin (HbF). HbF yakakwira yakaratidzwa kuti inodzivirira mhedzisiro inokuvadza ye sickle hemoglobin (HbS) uye inoderedza zviratidzo zveSCD nethalassemia, kusanganisira kudzivirira matambudziko eropa uye kuderedza hemolytic anemia.

BIOOCUS, boka rinotungamira munyaya dzekurapa majini, pamwe chete neLu Daopei Hospital, rave richibatsira zvikuru mukuunza kurapwa uku kutsva kuvarwere. 

Kubudirira kwekurapa uku hakuna kumboonekwa, varwere gumi nevashanu vakarapwa kusvika pari zvino, vese vachiwana zororo rakazara uye kuvandudzika kukuru muhupenyu hwavo. Mwero uyu wekurapwa 100% chiitiko chakakosha mukurwisa SCD nethalassemia.

Kurapa uku kwave kuzivikanwa pasi rose, nyanzvi pasi rose dzichikurumbidza sekubudirira mukurapa zvirwere zveropa zvemajini. Kunoonekwa kwete chete nekuda kwekushanda kwayo asiwo nekuda kwekushandisa kwayo mari shoma. Kusiyana nedzimwe nzira dzekurapa dzemajini, dzinogona kudhura zvakanyanya, kurapwa uku kunopa modhi yemitengo iri nyore, zvichiita kuti ive sarudzo inoshanda kune varwere vakawanda.

Mune imwe nyaya inonetsa, murwere ane makore gumi nemaviri ekuberekwa ane matambudziko eropa anodzokororwa uye ane ropa shoma rakanyanya kubva muropa akasangana nekupera kwezviratidzo mushure mekurapwa nekurapa majini aya. Nyaya iyi, pakati pezvimwe, inoratidza kugona kwekurapa kwevarwere veSCD nethalassemia pasi rese.

Sezvo BIOOCUS ichiramba ichiwedzera kuwanikwa kwekurapa uku, kusanganisira miedzo yekiriniki iri kuuya muChina, ramangwana rinotaridzika serine tariro kune avo vane zvirwere izvi zvakaoma. Nerutsigiro rweLu Daopei Hospital, kurapwa uku kwakarongerwa kutsanangura patsva mwero wekutarisira kweSCD nethalassemia, zvichipa mukana mutsva wehupenyu hwevarwere vasingaverengeki.

Kana iwe kana mumwe munhu waunoda ari kubatwa nechirwere chesickle cell kana thalassemia uye achida kutsvaga mushonga uyu mutsva, tinokukoka kuti utibate. Chikwata chedu chakagadzirira kukupa rutsigiro neruzivo rwaunoda kuti uite sarudzo dzine ruzivo nezverwendo rwako rwehutano.

Rutsigiro Rwakakwana rweVarwere Vekunze Kwenyika Vari Kufamba Kuenda kuChina Kunorapwa Hemo-cell

KuBIOOCUS, takazvipira kupa rubatsiro rwakakura uye runobatsira varwere vekune dzimwe nyika vane chirwere chethalassemia kana sickle cell vari kutsvaga kurapwa kweHemo-cel kuChina. Mabasa edu akazara anosanganisira nhanho imwe neimwe yerwendo, kubva pakugadzirira rwendo kusvika pakutarisirwa mushure mekurapwa.

1. Kugadzirira Kufamba Usati Waenda

Varwere vasati vafamba, vachaongororwa zvakakwana muzvipatara zvemunharaunda yavo. Izvi zvinosanganisira kuongororwa kwakazara kwenhoroondo yezvekurapa, kuongororwa kwezviratidzo zvehupenyu, kuongororwa kweropa, uye kuongororwa kwakanangana nechirwere chethalassemia kana sickle cell. Tinova nechokwadi chekuti magwaro ese ekurapa, kusanganisira zvinyorwa zvekuisirwa ropa uye kusimbiswa kwekuongororwa, akanyorwa nemazvo uye anotumirwa kuchipatara chedu kuti aongororwe.

2. Kufamba uye Kurapwa muchipatara

Tinorerutsa maitiro ese ekufamba, kusanganisira kuronga kwekubhuka varwere vari muzvipatara zvakatarwa. Varwere vanotungamirirwa nemaitiro ekugamuchirwa pavanosvika, zvichiita kuti vashanduke zvakanaka vachipinda mukurapwa.

3. Maitiro Ekurapa

Mushure mekubvumidzwa kupinda muchipatara, varwere vachaongororwa kakawanda. Kana zvikaonekwa kuti vakakodzera, kuunganidzwa nekuunganidza masero eropa kunotanga. Masero aya anotumirwa kunzvimbo yedu yeGMP kuti vagadzirise mhando uye vagadzirise, panguva iyo varwere vanogona kudzokera kunyika dzavo kunomirira mimwe mirairo.

4. Kuisirwa uye Kutarisirwa kwekutevera

Kana masero emuviri agadzirwa abvumidzwa, varwere vanodzoka kuzoisirwa mamwe masero. Chikwata chedu chakazvipira kupa rutsigiro runogara ruchienderera mberi munguva yese yekuiswa muchipatara, tichiona kuti murwere wega wega anowana rubatsiro rwakasiyana. Mushure mekubuda muchipatara, tinoronga kuongororwa nguva nenguva kuti tione kupora uye kugara zvakanaka.

Pa BIOOCUS, tinokoshesa hutano nekunyaradzwa kwevarwere vedu vekune dzimwe nyika, tichiita zvese zvatinogona kuti tipe rubatsiro rwakakwana uye rutsigiro rwekurapa. Kuti uwane rumwe ruzivo nezvemabasa edu, ndapota taura nesu.