- Kurapa
- Uchapupu
- Neuroblastoma
- Gomarara Rakasimba
- Uchapupu
- TILS
- Kurapa Masero eNK
- Myasthenia Gravis (MG)
- Acute Lymphoblastic Leukemia (B-ALL)
- Systemic Lupus Erythematosus (SLE)
- Chirwere cheAcute Lymphoblastic Leukemia (T-ALL)
- Non Hodgkin Lymphoma (NHL)
- Multiple Myeloma (MM)
- Kuparadzira Lymphom yeB-cell yakakura
- B-lymphocytic Leukemia
- Myeloma
Kurapa kweCAR-T kweMyasthenia Gravis (MG)
Pfupiso
Myasthenia Gravis (MG) chirwere chisingaperi che autoimmune neuromuscular disorder chinokonzerwa ne autoantibodies (kunyanya anti-acetylcholine receptor antibodies, AchRAb) iyo inokanganisa kutaurirana pakati petsinga netsandanyama, zvichikonzera kushanduka-shanduka kwekushaya simba, ptosis, dysphagia, uye muzviitiko zvakakomba kutadza kufema kunotyisidzira hupenyu. Kune varwere vane refractory MG vanokundikana mishonga yekudzivirira muviri, IVIG, FcRn inhibitors, uye complement inhibitors, sarudzo dzekurapa dzinoramba dziri shoma.
Kurapa kweBIOOCUS kweCD19/BCMA CAR-T kwakaitwa nemapoka maviri kunomiririra nzira itsva yekurapa maseru e autologous iyo inobvisa masero eB ane hutachiona uye masero eplasma ane basa rekugadzira maantibody, zvichipa mukana wekurerukirwa kwakadzama uye kwenguva refu muMG yakaoma kurapa.
Chii chinonzi CAR-T Therapy yeMG?
Kurapa kweCAR-T kweMG inzira yepamusoro-soro yekudzivirira muviri inogadzirwa nemunhu wega wega umo masero eT emurwere akagadzirwa nemajini kuti abudise chimeric antigen receptors (CARs) achinanga kuCD19 (pamasero eB) neBCMA (pamasero eplasma). Mushure mekuwedzerwa murabhoritari, masero aya eCAR-T ane zvinangwa zviviri anodzoserwa mumurwere, uko anobvisa masero emuviri anotungamira kuMG, nokudaro achideredza mazinga eAchRAb uye achidzorera mashandiro etsinga dzemutsinga.
Iyi nzira yekurwisa zvirwere zviviri inobata zvese zvikamu zvemasero uye zvehumoral zve autoimmune response, zvichipa kudzorerwa kwakazara kwesimba remuviri rekudzivirira chirwere zvichienzaniswa nekurapa kwega kana kwechinyakare.
Mabhenefiti Akakosha ekurapa kweCAR-T paMG
- Kuvandudzwa kwezviratidzo nekukurumidza uye kwenguva refu: Kuderera kukuru kwekuneta kwetsandanyama, ptosis, diplopia, dysarthria, uye kushaya simba kwemakumbo.
- Kudzikira kwemasero eB-deep uye plasma-cell: Kuderera kwakakura uye kunogara kwenguva refu kweAchRAb uye huwandu hwese hweB-lymphocyte.
- Zviyero zvekiriniki zvakavandudzwa: Kubudirira kukuru muQuantitative Myasthenia Gravis (QMG) uye Activities of Daily Living (ADL) scores.
- Nzvimbo yakanaka yekuchengetedza: Inoshivirira zvakanaka isina cytokine release syndrome (CRS) kana neurotoxicity inowanikwa muzviitiko zvakarapwa.
- Mikana yekuregererwa kwenguva refu: Inoderedza kana kubvisa kudiwa kwekurapwa kwenguva refu kwezvirwere zvemuviri.
- Zvakagadzirirwa munhu uye zvakarurama: Inoshandisa masero emurwere pachake, zvichideredza njodzi yekuramba.
Maitiro Ekurapa
- Leukapheresis– Kuunganidzwa kwemasero eT emurwere kuburikidza ne peripheral blood apheresis.
- Uinjiniya hweMajini- Masero eT anogadziriswa kuti abudise maCD19 neBCMA CARs uye anowedzerwa munzvimbo dzeGMP.
- Kugadzirisa (kana zvichidikanwa)- Kubviswa kwema lymphocyte kwenguva pfupi kuti CAR-T ishande zvakanaka.
- Kupinzwa kweCAR-T– Kupinzwa kamwe chete kweCD19 CAR-T (0.5×10⁶/kg) + BCMA CAR-T (1×10⁶/kg).
- Kutarisa & Kutevera- Kuongororwa nguva dzose kwekuwedzera kweCAR-T, mazinga eAchRAb, huwandu hwemasero eB, mamakisi eQMG/ADL, uye mashandiro enhengo dzemuviri kwemwedzi inosvika gumi nemiviri zvichikwira.
Sei Uchifanira Kusarudza BiocUS's CAR-T Therapy yeMG?
- Puratifomu yeCD19/BCMA CAR-T ine hunyanzvi hwepamusoro-soro yakagadzirirwa zvirwere zve autoimmune.
- Chikwata chekugadzira GMP chepasi rose uye chine ruzivo rwekurapa zvirwere zvemuviri chine hunyanzvi muzvirwere zveropa uye zvirwere zve autoimmune zvinoramba kushanda.
- Rutsigiro rwakakwana rwevarwere vepasi rose: kutaurirana kwemitauro yakawanda, kutamiswa kwendege, pekugara, uye kuteverwa kwenguva refu.
- Ruzivo rwakaratidzwa muCAR-T rwezvirwere zve autoimmune (kusanganisira SLE) uye kuronga kurapwa kwakagadzirirwa munhu.
- Kutarisirwa kwakazara kubva pakuongororwa kwechirwere chisati chatanga kusvika pakutariswa mushure mekuiswa mushonga.
Nyaya Yekuongorora Nyaya Yemurwere: Mukadzi ane makore makumi maviri ekuberekwa (LYN) ane Refractory MG
Nhoroondo yeMurwere
- Yakaongororwa ine Myasthenia Gravis isingashande (CNGIIIa, AchRAb-positive) uye B3-type thymoma/thymic hyperplasia mushure mekuvhiyiwa.
- Zvimwe zvirwere: osteoporosis, musoro wemukadzi wepamuviri wepamuviri wepamuviri weparutivi petsoka dzechiuno nekuruboshwe, anemia yekushaikwa kwesimbi.
- Kurapa kwakasiyana-siyana kwakakundikana (2019–2025): ma steroids ane dose yepamusoro + azathioprine → tacrolimus → cyclosporine, IVIG yakadzokororwa, efgartigimod, eculizumab + telitacicept, uye rituximab (500 mg, haishande).
Kurapa kweCAR-T
- Mbudzi 2025: CAR-T protocol yakatanga; cyclosporine yakamira.
- Zvita 1, 2025: Kuunganidzwa kwemasero eropa remunonuclear.
- Zvita 15, 2025: Kuiswa kweCD19 CAR-T (0.5×10⁶/kg) + BCMA CAR-T (1×10⁶/kg).
- Hapana zviitiko zvakaipa zvakaonekwa mushure mekunyudzwa.
Mhedzisiro yeKurapwa Mushure meKurapwa (kubva munaKurume 2026)
- Kuwedzera kweCAR-T: Kukurumidza kuwedzera mumuviri neCD19 CAR-T yepamusoro paD10 (7.62%, 4.622×10⁷/L) uye BCMA CAR-T paD10 (17.17%, 1.0414×10⁸/L); kuonekwa kwenguva refu mumwedzi wechitatu.
- Kuvandudzwa kweLabhoritari:
- Kudzikira kukuru kwemazinga eAchRAb uye huwandu hwese hweB-lymphocyte.
- Kuwanda kweropa kwakasimba, mashandiro echiropa neitsvo.
- Mazinga eImmunoglobulin anotariswa (shanduko dzenguva pfupi dzinotarisirwa nekuda kwekupera kwemasero eB).
- Zvibodzwa zveKliniki: Kuvandudzika kunoonekwa muQMG neADL scores, zvichiratidza kudzikira kwekushaya simba kwetsandanyama uye kushanda zvakanaka kwezuva nezuva.
- Kurerutsira Zviratidzo: Kugadzikana kana kuvandudzika kukuru mu diplopia, kuomarara kwechiso, dysarthria, uye kuneta kwemakumbo.
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