Kurapa kweLumor-Infiltrating Lymphocyte (TIL): Nzira Inobatsira yekurapa Melanoma

Melanoma rudzi rwegomarara reganda rinotangira muma melanocytes, masero anogadzira melanin, ruvara runopa ganda ruvara rwaro. Inoonekwa seimwe yemhando dzegomarara dzinokatyamadza zvikuru nekuda kwekukwanisa kwayo kupararira kune dzimwe nhengo dzemuviri nekukurumidza. Kunyange hazvo melanoma yekutanga ichigona kurapwa zvinobudirira kuburikidza nekuvhiyiwa, melanoma yakafambira mberi kana yakapararira ine matambudziko makuru ekurapa. Mumakore achangopfuura, immunotherapy itsva dzakabuda senzira dzekurapa dzinovimbisa kune varwere vakakwira. Imwe nzira yakadaro ndeye Tumor-Infiltrating Lymphocyte (TIL) therapy, iyo inoshandisa immune system yemuviri kurwisa nekuparadza masero egomarara, ichipa tariro itsva kune varwere vane melanoma iri padanho rekupedzisira.

Kurapa negomarara (TIL) inzira itsva yekurapa nekudzivirira chirwere inoshandisa masero emuviri ekudzivirira chirwere kurwisa nekuparadza masero egomarara. Yave nzira yakanaka yekurapa melanoma inopararira, kunyanya muvarwere vasingapindure zvakanaka pakurapa kwakajairika kwakadai sekudzivirira immune checkpoint kana kurapwa kwakanangana.

Maitiro eTIL Therapy

Kurapa kweTIL kunosanganisira kubvisa masero eT kubva mubundu remurwere, kuawedzera kunze kwemuviri, uye wozoaisazve mumurwere mushure mekupiwa chemotherapy ne lymphodepleting. Aya masero eT anogadzirwa kuti azive uye arwise masero ebundu, zvichipa kurapwa kwakanangana zvikuru. Kana angodzoserwa mumuviri, anotsvaga uye anoparadza masero e melanoma, achibatsirwa nekupa interleukin-2 (IL-2), iyo inobatsira masero eT kurarama uye kuwanda.

Tsvagiridzo Yakakosha uye Zvakawanikwa

Van den Berg nevamwe (2020)vakaita chidzidzo chedanho rekutanga/rechipiri kuNetherlands Cancer Institute vakaona kuti kurapwa kweTIL kwakaita kuti varwere vane melanoma yakapararira vanzwe vakasimba uye kwenguva refu. Makumi mashanu muzana evarwere vakaratidza mhinduro yakanaka yekiriniki, vaviri vachiwana zororo rakakwana rakagara kwemakore anopfuura manomwe. Chidzidzo chacho chakaratidza kuti maTIL akapfuma kuti aite neoantigen-specific reactivity akaramba ari muropa kwemakore mushure mekurapwa, zvichibatsira mukudzivirira kenza kwenguva refu.

Gastman nevamwe (2021)vakaitisa bvunzo yeDELTA-1, iyo yakaongorora ITIL-168, rudzi rwekurapa kweTIL yega, muvarwere vane melanoma yakakwira vakadzokera shure kana kuti vakaramba kurapwa ne checkpoint inhibitor. Chidzidzo ichi chakawana kuti ITIL-168 inogona kupa sarudzo inoshanda yekurapa varwere vane dzimwe sarudzo shoma. Chidzidzo ichi chikuru chepasi rose chechikamu chechipiri chakaratidza mhedzisiro yakanaka, neongororo iri kuenderera mberi yakatarisana nekuongorora mabhenefiti enguva refu.

Rohan nevamwe (2018)Yakapa ongororo yakadzama yekurapa kweTIL, ichisimbisa kugona kwayo sekurapa kunokosha kwe melanoma. Kunyangwe mumamiriro ezvinhu aripo ekurapa kwakanangwa uye kudzivirira immune checkpoint inhibitors, kurapwa kweTIL kuchiri kushanda uye kunoshanda, kuchiratidza mhedzisiro yakasimba mukuyedzwa kwekiriniki. Ongororo iyi yakaratidza kukosha kwemishonga yekubvisa lymphodepleting uye kuwedzera kwehuwandu hweTIL kuti kuwedzere kushanda kwekurapa uku.

Zvakanakira uye Mirayiridzo Yeramangwana

Kurapa kweTIL kune zvakanakira zvakakosha zvakasiyana pane mamwe ma immunotherapy:

• Mhinduro Dzinogara Nguva Dzose: Sezvakaratidzwa muzvidzidzo zvenguva refu, kurapwa kweTIL kunogona kupa zororo rinogara kwenguva refu, kunyanya kune varwere vane melanoma yakakwira avo vasara nesarudzo shoma dzekurapa.
• Kudzivirirwa Kwakanangana: MaTIL akakodzera kurwisa masero egomarara sezvo anobva mugomarara remurwere, zvichiita kuti ave akanyatsojeka mukushanda kwawo.
• Kukwanisa Kusanganiswa: Kurapa kweTIL kune mukana wekubatanidzwa nedzimwe nzira dzekurapa dzinodzivirira chirwere kana nzira dzekurapa dzakanangana, zvichivandudza huwandu hwemhinduro uye kuwedzera hupenyu hwese.

Kurapa neTIL kunomiririra kufambira mberi kukuru mukurapa melanoma yakapararira, kunyanya kune varwere vasingapindure kune dzimwe nzira dzekurapa. Nekupindura kwakasimba uye kwakasimba, kurapwa uku kune vimbiso yekuva kurapwa kwakajairika munguva pfupi iri kutevera. Tsvagiridzo inoramba ichienderera mberi inodiwa kuti tiwedzere matekiniki ekuwedzera kweTIL uye kuona huwandu hwevarwere vakanakisisa vekurapa uku.