Kev Tswj Xyuas Cov Kev Mob Tshwm Sim Ntawm CAR-T Cell Therapy: Cov Kev Nkag Siab Tseem Ceeb Los Ntawm Kev Tshawb Fawb Tsis Ntev Los No
Ib txoj kev tshawb fawb tsis ntev los no tau luam tawm hauv Kev Kho Mob Hlwbqhia txog kev tswj hwm cov tshuaj lom uas cuam tshuam nrog Chimeric Antigen Receptor (CAR) T-cell therapy, kev kho mob tshiab rau B-Cell Lymphomas. Txawm hais tias kev kho mob CAR-T tau pom tias muaj kev vam meej zoo kawg nkaus hauv kev kho mob qog ntshav loj B-cell lymphoma uas rov qab los lossis tsis kho tau, nws kuj coj cov teeb meem loj heev vim muaj cov kev mob tshwm sim loj heev.
Txoj kev tshawb fawb no, uas Dr. S. Neelapu coj, tsom mus rau ob qho kev lom uas pom ntau tshaj plaws nrog kev kho mob CAR-T: cytokine release syndrome (CRS) thiab immune effector cell-associated neurotoxicity syndrome (ICANS). Cov kev lom no feem ntau tshwm sim sai tom qab CAR-T infusion thiab xav tau kev tswj hwm tam sim ntawd kom tiv thaiv cov teeb meem loj. CRS feem ntau tshwm sim nrog kub taub hau, ntshav qis, thiab ua pa nyuaj, thaum ICANS tuaj yeem ua rau tsis meej pem, qaug dab peg, thiab thaum mob hnyav, coma.
Tsab xov xwm no qhia txog qhov tseem ceeb ntawm kev txheeb xyuas thaum ntxov thiab kev ntsuas qib ntawm cov tshuaj lom no kom haum rau cov tswv yim kho mob. Nws kuj tham txog kev siv cov kev kho mob xws li tocilizumab rau CRS thiab corticosteroids rau ICANS, uas tau ua pov thawj tias muaj txiaj ntsig zoo hauv kev txo cov kev tsis haum tshuaj uas yuav ua rau tuag taus.
Ntxiv mus, daim ntawv tshaj tawm no tshawb nrhiav txog cov teeb meem lom mus sij hawm ntev, suav nrog kev ua rau cov qe ntshav tsawg zuj zus (kev txo qis ntawm cov qe ntshav dawb) thiab cov teebmeem ntawm lub hom phiaj, tsis yog mob qog nqaij hlav, uas xav tau kev saib xyuas thiab kev tswj hwm tas mus li. Kev tshawb fawb no hais tias, thaum kev kho mob CAR-T muaj peev xwm loj heev, cov kws kho mob yuav tsum tau npaj txhij los daws nws cov kev mob tshwm sim tshwj xeeb thiab loj heev.
Nrog rau kev sim tshuaj thiab kev tsim kho tshiab tas mus li, thaj chaw no txuas ntxiv tsim cov tswv yim zoo dua rau kev tswj cov tshuaj lom no, uas ua rau CAR-T kev kho mob siv tau zoo dua thiab muaj kev nyab xeeb dua.