Kev Kho Mob CAR-T Qhia Txog Kev Nyab Xeeb thiab Kev Ua Tau Zoo rau Cov Neeg Mob Cancer uas Muaj Kab Mob Autoimmune lossis Inflammation
Nyob rau hauv ib txoj kev tshawb fawb tshiab uas nyuam qhuav luam tawm hauv Phau ntawv Lancet Rheumatology, cov kws tshawb fawb los ntawm Dana-Farber Cancer Institute tau soj ntsuam qhov kev nyab xeeb thiab kev ua tau zoo ntawm CAR-T cell therapy rau cov neeg mob qog noj ntshav uas muaj keeb kwm ntawm autoimmune lossis inflammatory kab mob. Txoj kev tshawb fawb, uas tau tshuaj xyuas cov ntaub ntawv txij li xyoo 2017 txog 2023, suav nrog 604 tus neeg mob uas muaj lymphoma thiab Ntau yam mob myeloma, ntawm cov neeg no muaj 53 tus uas muaj mob autoimmune lossis inflammatory. Cov mob no suav nrog cov mob rheumatoid, nrog rau psoriasis yog qhov feem ntau.
Kev kho mob CAR-T cell, tshwj xeeb tshaj yog tsom mus rau CD19 thiab BCMA, tau pom tias muaj kev vam meej zoo hauv kev kho mob rov qab los thiab tsis kho tau B-Cell Lymphoma, mob ntshav dawb (leukemia), thiab mob ntshav ntau yam (multiple myeloma). Txawm li cas los xij, muaj kev txhawj xeeb txog nws txoj kev nyab xeeb thiab kev ua haujlwm zoo rau cov neeg mob uas muaj cov kab mob autoimmune lossis inflammatory uas twb muaj lawm, vim tias cov neeg mob no muaj feem yuav mob hnyav dua xws li cytokine release syndrome (CRS) thiab immune effector cell-associated neurotoxicity syndrome (ICANS).
Cov kev tshawb fawb pom tau tias qhov tshwm sim ntawm CRS thiab ICANS hauv cov neeg mob uas muaj kab mob autoimmune lossis inflammatory zoo ib yam li cov neeg mob uas tsis muaj cov mob no. Tshwj xeeb, cov nqi ntawm CRS hnyav yog tsawg heev, tsis muaj qhov sib txawv tseem ceeb ntawm ob pawg. Qhov tshwm sim ntawm ICANS kuj zoo sib xws, qhia tias CAR-T kev kho mob muaj kev nyab xeeb rau cov neeg mob no.
Hais txog kev ua tau zoo, tsis muaj qhov sib txawv tseem ceeb hauv kev ciaj sia tsis muaj kev nce qib (PFS) thiab kev ciaj sia tag nrho (OS) ntawm ob pawg, ntxiv qhov lees paub tias qhov muaj cov kab mob autoimmune lossis inflammatory tsis cuam tshuam rau qhov Kev Kho Mob Cancer cov txiaj ntsig. Qhov nthuav yog, txoj kev tshawb fawb kuj tau pom tias muaj kev txhim kho hauv kev ua haujlwm ntawm cov kab mob autoimmune tom qab kev kho mob. Kev txo qis ntawm qhov xav tau cov tshuaj tiv thaiv kab mob tau pom, thiab kev kis tus kab mob tsawg dua hauv pawg kho mob.
Txoj kev tshawb fawb no muab pov thawj zoo txhawb kev siv CAR-T kev kho mob rau cov neeg mob uas muaj cov kab mob autoimmune lossis inflammatory, qhia tias nws yog ib qho kev xaiv zoo rau ntau tus neeg mob qog noj ntshav. Cov kev tshawb pom txhawb kom muaj kev tshawb fawb ntxiv los tshawb nrhiav cov txiaj ntsig ntawm CAR-T kev kho mob hauv cov neeg mob tshwj xeeb no.
Raws li CAR-T kev kho mob txuas ntxiv mus, cov txiaj ntsig no muab kev cia siab rau kev txhim kho cov kev xaiv kho mob thiab cov txiaj ntsig rau cov neeg mob uas muaj keeb kwm kev kho mob nyuaj.