Xov Xwm Kev Lag Luam
Kev Kho Mob CAR-T Kov Yeej Qhov Kev Kwv Yees Tsis Zoo Hauv Cov Kab Mob Lymphoma Qib Siab B-Cell
Ib txoj kev tshawb fawb tshiab qhia tau hais tias kev kho mob CAR-T tuaj yeem txhim kho qhov kev kwv yees rau cov neeg mob uas muaj cov kab mob B-cell lymphoma theem siab (HGBL), uas yog ib hom kab mob B-cell lymphoma loj, txawm tias nyob rau hauv cov kab kho mob tom qab, muab kev cia siab tshiab rau cov teeb meem nyuaj no.
Kev Tswj Xyuas Cov Teeb Meem Ntev ntawm Kev Kho Mob CAR-T: Kev Nkag Siab Los Ntawm Xwm Kab Mob Cancer
Ib txoj kev tshawb fawb tsis ntev los no tau luam tawm hauv Mob Cancer Xwm qhia txog cov teeb meem mus sij hawm ntev ntawm kev kho mob CAR-T cell, tsom mus rau kev pheej hmoo ntawm kev kis kab mob thiab cov kab mob qog nqaij hlav thib ob, thiab muab cov tswv yim los ua kom cov txiaj ntsig zoo tshaj plaws rau tus neeg mob.
Kev Kov Yeej Cov Kev Cov nyom hauv Kev Kho Mob CAR-T rau Cov Mob Cancer Ntshav T-Cell
Txawm hais tias kev kho mob CAR-T tau hloov pauv txoj kev kho mob qog nqaij hlav B-cell, tseem muaj teeb meem loj heev hauv kev kho mob qog nqaij hlav T-cell. Kev tshuaj xyuas tsis ntev los no tshawb nrhiav qhov nyuaj ntawm kev kho mob CAR-T hauv cov qog nqaij hlav ntshav T-cell thiab cov kev daws teeb meem los kov yeej cov teeb meem no.
Kev Nkag Siab Txog Thalassemia: Ib Phau Ntawv Qhia Txog Alpha thiab Beta Forms
Thalassemia yog ntau tshaj ib yam kab mob. Phau ntawv qhia no tshawb nrhiav ob qho tib si alpha thiab beta thalassemia, lawv cov ua rau, cov tsos mob, thiab cov kev kho mob tshiab tshaj plaws muaj nyob rau ntawm BIOOCUS International Medical Center.
Kev Kho Mob NK Cell Ua Ke Nrog DC Vaccine Qhia Txog Kev Txhim Kho Zoo Kawg Nkaus Hauv Mob Cancer Qib Kawg
Muaj kev tshawb pom tshiab hauv kev kho mob qog noj ntshav siab uas tau tshwm sim los ntawm kev sib xyaw ua ke ntawm kev kho mob NK cell, tshuaj tiv thaiv DC, thiab Nivolumab. Kev kho mob ua ke no tau ua tiav zoo kawg nkaus, ua rau muaj kev txo qis ntawm cov qog thiab ua rau lub siab ua haujlwm zoo dua hauv rau lub lis piam rau tus neeg mob uas muaj mob qog noj ntshav siab theem kawg.
Kev Kho Mob Gene Tshiab Ua Tau Kev Tshawb Fawb Tshiab hauv Kev Kho Mob Sickle Cell Kab Mob thiab Thalassemia
Hauv ib rooj plaub kho mob uas tau tsim kho tshiab, ib tug neeg mob hnub nyoog 21 xyoo tau kov yeej cov teeb meem ntawm thalassemia los ntawm kev siv CRISPR-based gene therapy. Txoj kev tshiab no yog ib qho tseem ceeb hauv kev kho cov kab mob ntshav hnyav xws li kab mob sickle cell (SCD) thiab thalassemia.
Kev Tswj Xyuas Cov Kev Mob Tshwm Sim Ntawm CAR-T Cell Therapy: Cov Kev Nkag Siab Tseem Ceeb Los Ntawm Kev Tshawb Fawb Tsis Ntev Los No
Tsab xov xwm no qhia txog kev tshawb fawb tsis ntev los no txog kev tswj hwm cov tshuaj lom ntawm CAR-T cell therapy rau B-cell lymphomas. Kev tshawb fawb no hais txog cov tswv yim los daws cov teeb meem tshwm sim xws li cytokine release syndrome (CRS) thiab neurotoxicity (ICANS), kom ntseeg tau tias kev siv txoj kev kho mob tshiab no muaj kev nyab xeeb dua.
Kev Siv Tau Ntev ntawm CD19 CAR T-Cell Therapy hauv Kev Kho Mob Relapsed/Refractory Acute Lymphoblastic Leukemia
Ib txoj kev tshawb fawb tshiab qhia txog kev vam meej mus sij hawm ntev ntawm CD19 CAR T-cell kev kho mob hauv kev kho cov neeg mob uas rov qab mob/tsis khov kho mob hlwb (ALL) tom qab kev hloov hlwb hlwb allogeneic hematopoietic, muab kev cia siab tshiab hauv kev kho mob ntshav.
Kev Txhim Kho Tshiab hauv Cov Qog Tua Neeg Ntuj (NK) Tshaj 50 Xyoo
Tau tsib xyoo dhau los no, kev tshawb fawb txog cov hlwb tua neeg ntuj (NK) tau hloov pauv peb txoj kev nkag siab txog kev tiv thaiv kab mob, muab cov kev cia siab tshiab rau kev kho mob qog noj ntshav thiab kab mob viral.
Kev Tshawb Fawb Tshiab hauv Kab Mob Autoimmune Rau Menyuam Yaus: CAR-T Cell Therapy Kho Tau Tus Neeg Mob Lupus
Ib txoj kev tshawb fawb thawj zaug ntawm Erlangen University Hospital tau kho tau ib tug ntxhais hnub nyoog 16 xyoo uas muaj mob hnyav hu ua systemic lupus erythematosus (SLE) siv CAR-T cell therapy. Qhov no yog thawj zaug siv txoj kev kho mob no rau cov menyuam yaus uas muaj mob lupus, thiab muab kev cia siab tshiab rau cov menyuam yaus uas muaj cov kab mob autoimmune.
Kev Txhim Kho Kev Ua Haujlwm Zoo ntawm PROTAC: Kev Tshawb Fawb Tshiab
Tsis ntev los no, kev tshawb fawb hauv Nature Communications tau qhia txog cov kev nkag siab tseem ceeb txog cov kev taw qhia intrinsic uas hloov kho qhov ua tau zoo ntawm kev rhuav tshem cov protein siv PROTACs. Qhov kev tshawb pom no tuaj yeem ua rau muaj kev kho mob zoo dua rau mob qog noj ntshav thiab lwm yam kab mob.
Kev Txhawb Kev Noj Qab Haus Huv thiab Kev Rov Zoo: Kev Saib Xyuas Txhua Hnub rau Cov Neeg Mob Leukemia
Kev ua kom muaj kev kho mob zoo thiab muaj kev nyab xeeb rau cov neeg mob leukemia yuav tsum tau saib xyuas txhua hnub, suav nrog kev tu cev ib puag ncig, kev tu cev tus kheej, kev noj zaub mov zoo, thiab kev tawm dag zog kom zoo. Phau ntawv qhia no muab cov lus qhia tseem ceeb rau kev saib xyuas txhua hnub kom zoo los txhawb kev rov zoo.