Kev Siv Tau Ntev ntawm CD19 CAR T-Cell Therapy hauv Kev Kho Mob Relapsed/Refractory Acute Lymphoblastic Leukemia
Hauv kev nce qib tseem ceeb hauv kev kho mob ntshav, kev tshawb fawb tsis ntev los no tau hais txog kev ua haujlwm ntev ntawm CD19 chimeric antigen receptor (CAR) T-cell therapy rau cov neeg mob uas raug kev txom nyem los ntawm kev rov qab los/refractory acute lymphoblastic leukemia (ALL) post-allogeneic hematopoietic stem cell transplantation (allo-HSCT). Kev tshawb fawb no, uas ua raws li cov neeg mob dhau sijhawm ntev, muab kev tshuaj xyuas dav dav ntawm cov txiaj ntsig, muab cov kev nkag siab tseem ceeb rau kev ua haujlwm ntev thiab kev nyab xeeb ntawm kev kho mob tshiab no.
Txoj kev tshawb fawb no tau saib xyuas cov neeg mob uas tau kho CD19 CAR T-cell tom qab rov qab mob ALL tom qab allo-HSCT. Cov txiaj ntsig zoo heev, qhia tau tias muaj ntau tus neeg mob tau zoo tag nrho, nrog rau cov lus teb tau pom ntau xyoo. Kev tshawb fawb no tsis yog tsuas yog qhia txog lub peev xwm kho mob ntawm CAR T-cell xwb tab sis kuj yog lub hauv paus tseem ceeb hauv kev kho mob qog ntshav, tshwj xeeb tshaj yog rau cov neeg uas muaj kev xaiv kho mob tsawg.
Ntxiv mus, txoj kev tshawb fawb no tshawb nrhiav txog kev nyab xeeb ntawm kev kho mob, qhia txog cov kev mob tshwm sim uas tswj tau, uas sib xws nrog cov kev tshawb pom ua ntej. Qhov no ua rau muaj kev ntseeg siab ntxiv rau kev kho mob CAR T-cell ua ib txoj kev kho mob zoo thiab siv tau rau cov neeg mob uas rov qab mob/tsis kho tau ALL, tshwj xeeb tshaj yog nyob rau hauv qhov chaw tom qab hloov pauv.
Raws li thaj chaw ntawm Kev kho mob tiv thaiv kab mob txuas ntxiv mus zuj zus, txoj kev tshawb fawb no ua lub teeb ci ntsa iab rau cov neeg mob thiab cov kws kho mob, cog lus tias yuav muaj yav tom ntej uas ntau tus neeg mob tuaj yeem ua tiav kev zam txim mus sij hawm ntev. Cov kev tshawb pom tsis yog tsuas yog pab txhawb rau cov pov thawj loj hlob uas txhawb nqa kev kho mob CAR T-cell xwb tab sis kuj tseem qhib txoj hauv kev rau kev tshawb fawb ntxiv kom zoo dua thiab nthuav nws txoj kev siv hauv kev kho mob.
Nrog rau qhov kev tshawb pom tshiab no, lub zej zog kho mob tau los ze rau kev hloov pauv thaj chaw kho mob rau cov kab mob hematological, muab kev cia siab tshiab rau cov neeg mob uas tawm tsam cov mob nyuaj no.