Ingufu z'igihe kirekire zo kuvura CD19 CAR T-cells mu kuvura Leukemia yo mu bwoko bwa Acute Lymphoblastic Leukemia yasubiwemo/yasubiwemo
Mu iterambere rikomeye mu bijyanye n'amaraso, ubushakashatsi buherutse gukorwa bwagaragaje akamaro k'igihe kirekire k'ubuvuzi bwa CD19 chimeric antigen receptor (CAR) T-cell therapy ku barwayi barwaye indwara yo kongera kugaragara/gusubira inyuma mu maraso nyuma yo gusimburwa kw'uturemangingo tw'amaraso (ALL) nyuma yo gusimburwa kw'uturemangingo tw'amaraso (allo-HSCT). Ubu bushakashatsi, bukurikirana abarwayi mu gihe kirekire, butanga isesengura ryimbitse ry'ibyavuye mu bushakashatsi, butanga ubumenyi bw'ingirakamaro ku kuramba n'umutekano w'ubu buryo bushya bwo kuvura.
Ubushakashatsi bwakurikiranye neza abarwayi bakorewe CD19 CAR-cell therapy nyuma yo kongera kurwara ALL nyuma ya allo-HSCT. Ibisubizo biratanga icyizere, bigaragaza ko umubare munini w'abarwayi bakize burundu, kandi ibisubizo birambye byagaragaye mu myaka yashize. Ubu bushakashatsi ntibugaragaza gusa ubushobozi bwo kuvura CAR-cell T ariko kandi bugaragaza intambwe ikomeye mu kuvura kanseri y'amaraso, cyane cyane ku bafite uburyo buke bwo kuvura.
Byongeye kandi, ubushakashatsi bwimbitse ku mutekano w’ubuvuzi, bugaragaza ingaruka mbi zishobora gukemuka, zari zijyanye n’ibyavumbuwe mbere. Ibi bishimangira icyizere gikomeje kwiyongera mu buvuzi bwa CAR T-cells nk’uburyo bwiza kandi bufite akamaro bwo kuvura ALL yasubiwemo/irwaye indwara yo mu mutwe, cyane cyane iyo umuntu amaze guterwa inshinge.
Nk'uko ishami rya Ubudahangarwa bw'umubiri Ubu bushakashatsi bukomeje gutera imbere, butanga icyizere ku barwayi ndetse n'abatanga serivisi z'ubuvuzi, busezeranya ahazaza aho abarwayi benshi bashobora kugabanya igihe kirekire. Ibyavuye muri ubu bushakashatsi ntibitanga gusa ibimenyetso byinshi bishyigikira ubuvuzi bwa CAR T-cells ahubwo binatanga inzira y'ubushakashatsi burambuye bwo kunoza no kwagura ikoreshwa ryabwo mu buvuzi.
Muri iyi ntambwe, umuryango w’abaganga wegereye guhindura uburyo bwo kuvura kanseri y’amaraso, bitanga icyizere gishya ku barwayi bahanganye n’izi ndwara zikomeye.