Kugwira Ntchito Kwanthawi Yaitali kwa Chithandizo cha CD19 CAR T-Cell Pochiza Matenda a Leukemia Obwerera M'mbuyo/Osasinthika
Pakupita patsogolo kwakukulu m'munda wa hematology, kafukufuku waposachedwapa wawonetsa kugwira ntchito kwa nthawi yayitali kwa chithandizo cha maselo a CD19 chimeric antigen receptor (CAR) T-cell mwa odwala omwe ali ndi relaxed/refractory acute lymphoblastic leukemia (ALL) post-allogeneic hematopoietic stem cell transplantation (allo-HSCT). Kafukufukuyu, yemwe amatsatira odwala kwa nthawi yayitali, amapereka kusanthula kwathunthu kwa zotsatira zake, kupereka chidziwitso chofunikira pa kulimba ndi chitetezo cha chithandizo chatsopanochi.
Kafukufukuyu anafufuza mosamala odwala omwe adalandira chithandizo cha maselo a CD19 CAR T atachira matenda a ALL pambuyo pa allo-HSCT. Zotsatira zake n'zolimbikitsa, zikusonyeza kuti odwala ambiri adachira kwathunthu, ndipo mayankho opitilira adawonedwa pazaka zambiri. Kafukufukuyu samangowonetsa kuthekera kwa chithandizo cha maselo a CAR T komanso akuwonetsa gawo lofunika kwambiri pakuchiza khansa ya m'magazi, makamaka kwa iwo omwe ali ndi njira zochepa zochiritsira.
Kuphatikiza apo, kafukufukuyu akuwunikanso za chitetezo cha mankhwalawa, ponena za zotsatirapo zoyipa zomwe zingachitike, zomwe zinali zogwirizana ndi zomwe zidapezeka kale. Izi zikulimbitsa chidaliro chomwe chikukulirakulira mu chithandizo cha maselo a CAR T ngati chithandizo chothandiza komanso chothandiza cha ALL yobwereranso/yosasinthika, makamaka m'malo omwe atumizidwa pambuyo poika munthu wina.
Monga gawo la Chithandizo cha Immunotherapy Ngakhale kuti kafukufukuyu akupitilizabe kusintha, akulonjeza tsogolo labwino kwa odwala ndi opereka chithandizo chamankhwala, zomwe zikulonjeza tsogolo labwino komwe odwala ambiri angapeze mpumulo kwa nthawi yayitali. Zomwe zapezekazi sizimangowonjezera umboni wochuluka wochirikiza chithandizo cha maselo a CAR T komanso zimatsegula njira yoti kafukufuku wina apitirire kukulitsa ndikuwonjezera kugwiritsa ntchito kwake m'malo azachipatala.
Ndi kupita patsogolo kumeneku, gulu lachipatala likuyandikira kusintha njira yochizira khansa ya m'magazi, zomwe zikupereka chiyembekezo chatsopano kwa odwala omwe akukumana ndi mavutowa.