Ukusebenza Kwesikhathi Eside Kokwelashwa Kwe-CD19 CAR T-Cell Ekwelapheni I-Relapsed/Refractory Acute Lymphoblastic Leukemia
Ekuthuthukeni okukhulu emkhakheni we-hematology, ucwaningo lwamuva nje lugcizelele ukusebenza kahle kwesikhathi eside kokwelashwa kwe-CD19 chimeric antigen receptor (CAR) T-cell ezigulini ezihlushwa ukufakelwa kwe-stem cell ye-hematopoietic ephindaphindayo/engaphenduli kahle (ALL) post-allogeneic hematopoietic (allo-HSCT). Ucwaningo, olulandela iziguli isikhathi eside, lunikeza ukuhlaziywa okuphelele kwemiphumela, lunikeza ukuqonda okubalulekile ngokuqina nokuphepha kwalokhu kwelashwa okusha.
Ucwaningo lulandele ngokucophelela iziguli ezazithole ukwelashwa kwe-CD19 CAR T-cell ngemuva kokubuyela emuva kwe-ALL ngemuva kwe-allo-HSCT. Imiphumela iyathembisa, ikhombisa ukuthi ingxenye enkulu yeziguli ithole ukuphulukiswa okuphelele, kanye nezimpendulo eziqhubekayo ezibonwe eminyakeni edlule. Lolu cwaningo alugcini nje ngokugcizelela amandla okwelapha okwelashwa kwe-CAR T-cell kodwa futhi luphawula ingqophamlando ekwelapheni umdlavuza wegazi, ikakhulukazi kulabo abanezinketho zokwelapha ezilinganiselwe.
Ngaphezu kwalokho, lolu cwaningo luhlola iphrofayili yokuphepha yokwelashwa, lubika imiphumela emibi elawulekayo, ehambisana nokutholakele kwangaphambilini. Lokhu kuqinisa ukuzethemba okukhulayo ekwelashweni kwe-CAR T-cell njengokwelashwa okusebenzayo nokuphumelelayo kwe-ALL ephinde yabuya/engasasebenzi, ikakhulukazi endaweni yangemva kokufakelwa.
Njengoba insimu ye Ukwelashwa nge-immunotherapy Njengoba iqhubeka nokukhula, lolu cwaningo lusebenza njengesibani sethemba ezigulini kanye nabahlinzeki bezempilo ngokufanayo, luthembisa ikusasa lapho iziguli eziningi zingafinyelela khona ukuphulukiswa kwesikhathi eside. Okutholakele akugcini nje ngokufaka isandla ebufakazini obukhulayo obusekela ukwelashwa kwe-CAR T-cell kodwa futhi kuvula indlela yocwaningo olwengeziwe lokuthuthukisa nokwandisa ukusetshenziswa kwayo ezindaweni zezokwelapha.
Ngale ntuthuko, umphakathi wezokwelapha usondela ekuguquleni isimo sokwelashwa kwezifo ezibangelwa umdlavuza wegazi, okunikeza ithemba elisha ezigulini ezilwa nalezi zimo ezinzima.