Te Whai Huatanga Roa o te Whakaora Pūtau-T CD19 CAR ki te Maimoa i te Leukemia Lymphoblastic Whakapeka/Whakakeke
I roto i tētahi whanaketanga nui i roto i te mara o te hematology, kua whakaatuhia e tētahi rangahau tata nei te whai huatanga roa o te rongoā CD19 chimeric antigen receptor (CAR) T-cell i roto i ngā tūroro e pāngia ana e te relapsed/refractory acute lymphoblastic leukemia (ALL) post-allogeneic hematopoietic stem cell transplantation (allo-HSCT). Ko te rangahau, e whai ake nei i ngā tūroro mō tētahi wā roa, e tuku ana i tētahi tātaritanga whānui o ngā putanga, e whakarato ana i ngā māramatanga whai hua ki te roa me te haumaru o tēnei maimoatanga auaha.
I āta tirohia e te rangahau ngā tūroro i whiwhi i te rongoā pūtau-T CD19 CAR i muri i te hokinga mai o te ALL i muri i te allo-HSCT. He pai ngā hua, e whakaatu ana i te nui o ngā tūroro i whiwhi i te whakaoranga katoa, me ngā urupare pumau i kitea i roto i ngā tau. Ehara i te mea ko tēnei rangahau anake te whakanui i te kaha whakaora o te rongoā pūtau-T CAR engari he tohu hoki i tētahi tohu nui i roto i te maimoatanga o ngā mate pukupuku toto, inā koa mō te hunga he iti noa ngā kōwhiringa maimoatanga.
Hei tāpiritanga, ka rukuhia e te rangahau te āhua haumaru o te rongoā, me te ripoata i ngā pānga taha ka taea te whakahaere, he rite ki ngā kitenga o mua. Ka whakakaha ake tēnei i te whakapono e tipu haere ana ki te rongoā pūtau-T CAR hei rongoā whai hua, whai hua hoki mō te ALL e hoki whakamuri ana/e ātete ana ki te mate, inā koa i roto i te horopaki whai muri i te whakawhitinga.
Hei te mara o Te rongoā ārai mate kei te whanake tonu, he tohu tumanako tēnei rangahau mō ngā tūroro me ngā kaiwhakarato hauora, me te oati i tētahi heke mai ka taea e te nuinga o ngā tūroro te whakatutuki i te murunga mō te wā roa. Ehara i te mea ko ngā kitenga anake e whai wāhi ana ki te tipu haere o ngā taunakitanga e tautoko ana i te rongoā pūtau-T CAR engari ka whakatakoto hoki i te ara mō ētahi atu rangahau hei arotau me te whakawhānui ake i tōna whakamahinga i roto i ngā taiao haumanu.
Nā tēnei putanga hou, kua tata te hapori hauora ki te whakarerekē i te āhua o te maimoatanga mō ngā mate pukupuku toto, me te tuku anō i te tumanako ki ngā tūroro e whawhai ana ki ēnei āhuatanga uaua.