Ukusebenza kwexesha elide koNyango lwe-CD19 CAR T-Cell ekunyangeni i-Relapsed/Refractory Acute Lymphoblastic Leukemia
Kwinkqubela phambili ebalulekileyo kwicandelo le-hematology, uphando lwakutshanje luye lwagxininisa ukusebenza kwexesha elide konyango lwe-CD19 chimeric antigen receptor (CAR) T-cell kwizigulane ezinesifo sokufakelwa kweeseli ze-hematopoietic stem cell (allo-HSCT) eziphinde zabuyela kwi-refractory/refractory acute lymphoblastic leukemia (ALL). Olu phononongo, olulandela izigulane ixesha elide, lubonelela ngohlalutyo olupheleleyo lweziphumo, lubonelela ngengqiqo ebalulekileyo malunga nokuqina kunye nokhuseleko lolu nyango lutsha.
Olu phononongo lulandele ngononophelo izigulane ebezifumene unyango lwe-CD19 CAR T-cell emva kokuba ziphinde zafumana unyango lwe-ALL emva kwe-allo-HSCT. Iziphumo ziyathembisa, zibonisa ukuba inani elikhulu lezigulane lifumene ukuphumla ngokupheleleyo, kunye neempendulo eziqhubekayo ezibonwe kwiminyaka edlulileyo. Olu phando alugcini nje ngokugxininisa amandla okunyanga e-CAR T-cell therapy kodwa lukwaphawula isiganeko esibalulekileyo kunyango lwe-hematological monicancies, ngakumbi kwabo baneendlela ezimbalwa zonyango.
Ngaphezu koko, olu phononongo lujonga kwiprofayili yokhuseleko lonyango, lubika ngeziphumo ebezingalindelekanga ezilawulekayo, ezazihambelana neziphumo zangaphambili. Oku kuqinisa ukuzithemba okukhulayo kunyango lwe-CAR T-cell njengonyango olusebenzayo nolusebenzayo kwi-ALL ebuyela umva/engalawulekiyo, ngakumbi kwimeko yasemva kokufakelwa.
Njengoko intsimi ye Unyango lwe-immunotherapy Njengoko olu phononongo luqhubeka lutshintsha, lusebenza njengesibane sethemba kwizigulana nakubaboneleli beenkonzo zonyango ngokufanayo, luthembisa ikamva apho izigulana ezininzi zinokufikelela ekuxolelweni kwexesha elide. Ezi ziphumo azincedi nje kuphela kubungqina obukhulayo obuxhasa unyango lwe-CAR T-cell kodwa zikwavula indlela yophando olongezelelweyo lokuphucula nokwandisa ukusetyenziswa kwalo kwiindawo zonyango.
Ngenxa yale mpumelelo, uluntu lwezonyango lusondela ekuguquleni imeko-bume yonyango lwezifo zegazi, nto leyo enika ithemba elitsha kwizigulana ezilwa nezi meko zinzima.