Uphononongo oluPhambili luqinisekisa uKhuseleko kunye nokusebenza kakuhle koNyango lwe-CD19/CD20 CAR-T kwi-r/r B-NHL

Uphononongo olutsha olupapashwe kwi Igaziigxininisa uphuhliso oluphumeleleyo lwe-prizloncabtagene autoleucel (prizlon-cel), unyango olutsha lwe-CD19/CD20-target CAR-T cell therapy, lokunyanga i-relapse/refractory B-cell I-Non-Hodgkin Lymphoma (r/r B-NHL). Olu vavanyo, oluyinqanaba loku-1, uphando oluneziko ezininzi, oluvulelekileyo olwenziwe eTshayina, lunika idatha ethembisayo malunga nokhuseleko kunye nokusebenza kakuhle kwale ndlela ijolise kwizinto ezimbini.

Lukhokelwa liqela labaphandi abadumileyo abavela kumaziko aquka iSibhedlele iFirst Affiliated Hospital saseZhejiang kunye neYunivesithi yaseTongji, olu phononongo lubhalise izigulane ezingama-48 ezine-r/r B-NHL, uninzi lwazo olukhulu. I-B-Cell Lymphoma (LBCL). Izigulana zazikhe zafumana unyango oluphakathi lweendlela ezintathu. Abathathi-nxaxheba banikwa i-prizlon-cel enye emva konyango lwe-lymphodepleting, kunye needosi ezifikelela kumanqanaba amathathu (DL1, DL2, kunye neDL3).

Iziphumo eziphambili:

• Iprofayili yoKhuseleko: Akukho tyhefu ithintela idosi (DLT) ebonweyo, kwaye unyango lubonise iziphumo ebezingalindelekanga ezilawulekayo. I-Cytokine release syndrome (CRS) yenzeka kwi-93.8% yezigulane, uninzi lwazo lukwibanga loku-1 ukuya kwelesi-2, kunye nomntu omnye kuphela kwibanga lesi-3. I-immunoeffector cell-associated neurotoxicity syndrome (ICANS) yayingaqhelekanga kwaye ilula, kungekho ziganeko zebanga lesi-3 okanye ngaphezulu.
• Ukusebenza kakuhle: Izinga lokuphendula lilonke (ORR) elingama-91.5% lifikelelwe, kunye nezinga lokuphendula lilonke (CR) elingama-85.1%. Phakathi kwezigulane ze-LBCL, amazinga e-ORR kunye ne-CR ayengama-90.7% kunye nama-86.0%, ngokwahlukeneyo. Okumangalisayo kukuba, ama-48.9% ezigulane agcine i-CR kulandelelwano lokugqibela, kwaye ezinye iimpendulo zidlule iminyaka emithathu.
• Iziphumo zokusinda: Uqikelelo lukaKaplan-Meier lubonise ubude beminyaka emi-2 yokuphendula (i-DOR), ukusinda okungenankqubela phambili (i-PFS), kunye namazinga okusinda ngokubanzi (i-OS) angama-66.0%, ama-62.6%, kunye nama-76.5%, ngokwahlukeneyo. Kwizigulane ze-CR, la mazinga ayephezulu nangakumbi.

I-Prizlon-cel ibonakalise ukukhula okuqinileyo kunye nokuqina kwexesha elide, kunye nexesha eliphakathi lokubuyisela iiseli ze-B zeentsuku ezili-185. Uyilo lwayo olujolise kabini lujongana nokubaleka kwe-antigen, indlela eqhelekileyo yokuxhathisa kwiindlela zonyango ze-CAR-T.