Kafukufuku Wotsogola Akutsimikizira Chitetezo ndi Kugwira Ntchito kwa Chithandizo cha CD19/CD20 CAR-T pa r/r B-NHL

Kafukufuku watsopano wofalitsidwa mu Magaziikuwonetsa bwino chitukuko cha prizloncabtagene autoleucel (prizlon-cel), chithandizo chatsopano cha maselo a CAR-T cholunjika ku CD19/CD20, chochiritsira maselo a B omwe abwereranso/osasinthika. Lymphoma Yosakhala ya Hodgkin (r/r B-NHL). Kuyesaku, komwe ndi gawo loyamba, kafukufuku wa malo ambiri, wotseguka wochitidwa ku China, kumapereka deta yodalirika yokhudza chitetezo ndi kugwira ntchito kwa njira iyi yolunjika mbali ziwiri.

Motsogozedwa ndi gulu la ofufuza otchuka ochokera m'mabungwe kuphatikizapo Chipatala Choyamba Chogwirizana cha Zhejiang University ndi Yunivesite ya Tongji, kafukufukuyu adalembetsa odwala 48 omwe ali ndi r/r B-NHL, ambiri mwa iwo anali akuluakulu. B-Cell Lymphoma (LBCL). Odwala anali atalandira kale chithandizo chapakati cha mitundu itatu. Ophunzirawo adalandira chithandizo chimodzi cha prizlon-cel atalandira mankhwala a lymphodepleting chemotherapy, omwe ali ndi milingo yosiyanasiyana m'magawo atatu (DL1, DL2, ndi DL3).

Zomwe Zapezeka:

• Mbiri Yachitetezo: Palibe mankhwala oletsa kumwa mankhwala (DLT) omwe adapezeka, ndipo chithandizochi chinawonetsa zotsatirapo zoyipa zomwe zingatheke. Cytokine release syndrome (CRS) idachitika mwa odwala 93.8%, makamaka a giredi 1-2, ndipo wodwala m'modzi yekha wa giredi 3 adapezeka. Immune effector cell-associated neurotoxicity syndrome (ICANS) inali yosowa komanso yofatsa, yopanda zochitika za giredi 3 kapena kuposerapo.
• Kugwira ntchito bwino: Chiwerengero cha mayankho onse (ORR) cha 91.5% chinapezeka, ndipo chiwerengero cha mayankho onse (CR) cha 85.1%. Pakati pa odwala a LBCL, chiwerengero cha ORR ndi CR chinali 90.7% ndi 86.0% motsatana. Chodabwitsa n'chakuti, 48.9% ya odwala adakhala ndi CR pa nthawi yomaliza yotsatiridwa, ndipo mayankho ena adapitilira zaka zitatu.
• Zotsatira za Kupulumuka: Ziwerengero za Kaplan-Meier zasonyeza kuti nthawi ya zaka ziwiri ya yankho (DOR), kupulumuka kosapitirira muyeso (PFS), ndi kuchuluka kwa kupulumuka konse (OS) kwa 66.0%, 62.6%, ndi 76.5% motsatana. Mwa odwala a CR, kuchuluka kumeneku kunali kwakukulu kwambiri.

Prizlon-cel inasonyeza kukula kwamphamvu komanso kupirira kwa nthawi yayitali, ndi nthawi yapakati yochira maselo a B ya masiku 185. Kapangidwe kake kamene kali ndi zolinga ziwiri kamathandiza kuthawa kwa antigen, njira yodziwika bwino yolimbana ndi ma CAR-T.