Kua huraina te TIL Therapy: Te tūhura i te whenua o te Immunotherapy Matepukupuku

Ko te rongoā TILs ko te tango i ngā lymphocytes e uru ana ki te pukupuku (TILs), arā, ko ngā pūtau ārai mate tūturu tino tika i roto i te tinana o te tūroro, mai i te pukupuku, ā, ka whakatupuhia i roto i te maha i roto i te taiwhanga. Kātahi ka whakahokia mai ēnei TIL kua whakahohehia ki roto i te tinana o te tūroro hei whakapakari i te kaha o te pūnaha ārai mate ki te aro me te patu i ngā pūtau matepukupuku. Ka mahi ngā TIL mā te kite i ngā tohu motuhake i runga i ngā pūtau matepukupuku, ā, ka whakarewahia he urupare ārai mate ki a rātou, ka mutu, ka arahi ki te whakangaromanga o te pukupuku.

E ai ki ā mātou hua maimoatanga haumanu, ko te whai huatanga whānui o te rongoā TIL kotahi e eke ana ki te 40%, koia te tikanga maimoatanga pukupuku tino whai hua i tua atu i te pokanga e wātea ana i tēnei wā. Ka whakarite a Bioocus i tētahi mahere maimoatanga whānui mō ia tūroro takitahi. Ka honoa tētahi, ētahi rānei maimoatanga ki te rongoā Tils, ka piki ake te tere whai huatanga whānui ki te neke atu i te 80%. Ko te whāinga o te rongoā whakakotahi he whakaiti i te kawenga pukupuku i te wā poto, ā, ka whakaratohia e tils he whai wāhitanga mō te tūroro kia ora ai i te wā roa.

Teitei o te motuhaketanga: ngā pūtau-T motuhake ki te pukupuku kua whakaaweawetia e ngā antigens pukupuku, kua mōhiotia e ngā TCR maha

Te kaha o te toropisi: te nui o te whakaaturanga o ngā kaiwhakawhiwhi chemokine, te kaha o te tropism pukupuku, me te tere ake o te mahi

Te patu i ngā pukupuku: Ka whakahohehia ngā TIL, ka whakanuia ki te 109-1011, ā, ka whakakorea ngā pūtau matepukupuku toenga i muri i te pokanga.

Pānga tonu: He nui te ōwehenga o ngā pūtau-T mahara, ā, ka taea e rātou te ora i roto i te tinana mō te wā roa, me te aroturuki tonu hoki.

Te haumaru teitei: te tango, te whakanui, te kore tauhohenga whakakore, me te SAE o ngā pūtau TIL mai i ngā tūroro tonu

I kitea he whai hua te rongoā Tils i roto i NSCLC (matepukupuku pūkahukahu kore-pūtau iti),Melanoma, Matepukupuku o te Ū, Matepukupuku o te kōpū, me te Matepukupuku o te Wheua. 

Haunga te tango pokanga i te pukupuku tuatahi, ka taea hoki te tango i te kiko pukupuku o waho, ngā kōpū lymph, te pleural effusion, te ascites, me ētahi atu. Ko te whakatauranga whai huatanga e whai ake nei: te whara tuatahi ≥ te whara metastatic ≥ ngā kōpū lymph ≥ ascites.

"Ko tā mātou tukanga whakatipu TIL i whakawhanakehia motuhaketia ka eke ki te ≥85% te angitu." Mēnā he tauira kiko noa o te ≥1cm3, ka taea te whakatipu i ngā piriona TIL, ā, he kaha te mahi paitini pūtau a ngā pūtau."

1.Nō te tūroro ake ngā TIL, nō reira kāore he mōrearea o te panga, e whakarite ana i te haumaru teitei.

2. Ngā pānga kino: He mea noa te kirika (nā te tukunga o ngā cytokine i te wā e whakakorea ana te pukupuku e te pūtau o ngā TIL, ka puta te kirika poto, kāore e hiahiatia he maimoatanga motuhake, ā, ka memeha noa iho).

3. Ko ētahi atu pānga kino i pūrongohia i roto i ngā rangahau ko te thrombocytopenia, te febrile neutropenia, te toto toto tiketike, me ētahi atu, ko te nuinga e pā ana ki ngā TIL i te taha o ētahi atu rongoā pēnei i te chemotherapy i mua i te maimoatanga (cyclophosphamide + fluorouracil), te IL-2 horopeta nui, ngā paturopi monoclonal PD-1, me ētahi atu.