E whakaatu ana te rongoā CAR-T i te haumaru me te whai huatanga i roto i ngā tūroro matepukupuku me ngā mate pūnaha ārai mate, mumura rānei

I roto i tētahi rangahau hou i whakaputaina tata nei i roto i Te Rheumatology a Lancet, kua arotakehia e ngā kairangahau o te Dana-Farber Cancer Institute te haumaru me te whai huatanga o te rongoā pūtau CAR-T i roto i ngā tūroro mate pukupuku he hītori o ngā mate pūnaha ārai mate, mate mumura rānei. Ko te rangahau, i arotake i ngā raraunga mai i te tau 2017 ki te 2023, i whakaurua ki roto ko te 604 ngā tūroro he lymphoma me Myeloma maha, e 53 o rātou he mate pūnaha ārai mate, he mate mumura rānei. I roto i ēnei mate ko ngā mate rheumatoid, ko te psoriasis te mea tino noa.

Kua whakaatuhia e te rongoā pūtau CAR-T, e aro nui ana ki te CD19 me te BCMA, he angitu whakamiharo ki te rongoā i te hunga kua hoki whakamuri me te hunga uaua ki te mahi. Lymphoma Pūtau-B, te mate pukupuku toto, me te myeloma maha. Heoi anō, kua ara ake ngā āwangawanga mō tōna haumaru me tōna whai huatanga i roto i ngā tūroro kua pāngia e ngā mate pūnaha ārai mate, mate mumura rānei, nā te mea he nui ake te mōrearea o ēnei tūroro ki ngā tauhohenga kino pērā i te cytokine release syndrome (CRS) me te immune effector cell-associated neurotoxicity syndrome (ICANS).

I kitea i roto i te rangahau he rite tonu te auau o te CRS me te ICANS i roto i ngā tūroro he mate pūnaha ārai mate, he mate mumura rānei ki ērā o ngā tūroro kāore i te pāngia e ēnei āhuatanga. Ina koa, he iti noa iho ngā auau o te CRS kino, kāore he rerekētanga nui i waenga i ngā rōpū e rua. He rite tonu hoki te auau o te ICANS, e kī ana he haumaru te rongoā CAR-T mō ēnei tūroro.

Mō te whai huatanga, kāore he rerekētanga nui i roto i te oranga kore-haere whakamua (PFS) me te oranga whānui (OS) i waenga i ngā rōpū e rua, e whakaū ana i te kore o te pānga kino o ngā mate pūnaha ārai mate, mate mumura rānei ki te Te Maimoatanga Matepukupuku ngā putanga. He mea whakamere, i kitea anō hoki e te rangahau ngā whakapainga o te mahi a te mate pūnaha ārai mate i muri i te maimoatanga. I kitea he whakahekenga nui o te hiahia mō ngā rongoā ārai mate, ā, he iti ake te auau o te putanga mai o te mate i roto i te rōpū maimoatanga.

Kei roto i tēnei rangahau he taunakitanga pakari e tautoko ana i te whakamahinga o te rongoā CAR-T i roto i ngā tūroro e pāngia ana e ngā mate pūnaha ārai mate, mate mumura rānei, e tohu ana he kōwhiringa pai tēnei mō te whānuitanga o ngā tūroro mate pukupuku. Ka akiakihia e ngā kitenga ētahi atu rangahau whakamua hei tūhura i ngā painga pea o te rongoā CAR-T i roto i tēnei taupori tūroro ahurei.

I te whanaketanga tonu o ngā maimoatanga CAR-T, ka tukuna e ēnei hua te tumanako hei whakapai ake i ngā kōwhiringa maimoatanga me ngā putanga mō ngā tūroro he uaua ō rātou hītori hauora.