Kurapa kweCAR-T Kunoratidza Kuchengetedzeka uye Kubudirira Muvarwere Vegomarara Vane Zvirwere Zvinorwisa Muviri Wemuviri Kana Zvirwere Zvinozvirwisa
Muchidzidzo chitsva chakaburitswa munguva pfupi yapfuura mu Kurapa kweLancet Rheumatology, vaongorori vekuDana-Farber Cancer Institute vakaongorora kuchengetedzeka uye kushanda kweCAR-T cell therapy muvarwere vegomarara vane nhoroondo yezvirwere zve autoimmune kana kuzvimba. Chidzidzo ichi, chakaongorora data kubva muna 2017 kusvika 2023, chaisanganisira varwere 604 vane lymphoma uye Multiple Myeloma, avo 53 vavo vaive nematambudziko ekudzivirira muviri kana kuzvimba. Matambudziko aya aisanganisira zvirwere zverheumatoid, psoriasis ndiyo yakanyanya kuwanda.
Kurapa nemasero eCAR-T, kunyanya CD19 neBCMA, kwaratidza kubudirira kukuru mukurapa vanhu vane chirwere chekudzoka kwechirwere uye chisingadzoreki. B-Cell Lymphoma, leukemia, uye multiple myeloma. Zvisinei, pane kunetsekana pamusoro pekuchengetedzeka kwayo uye kushanda kwayo muvarwere vane zvirwere zve autoimmune kana kuzvimba, sezvo varwere ava vari panjodzi huru yekukuvara zvakanyanya se cytokine release syndrome (CRS) uye immune effector cell-associated neurotoxicity syndrome (ICANS).
Ongororo iyi yakawana kuti kuwanda kweCRS neICANS muvarwere vane zvirwere zve autoimmune kana kuzvimba kwakafanana nekwevarwere vasina zvirwere izvi. Kunyanya, mwero weCRS yakanyanya waive mudiki, pasina mutsauko wakakosha pakati pemapoka maviri aya. Kuwanikwa kweICANS kwakafananawo, zvichiratidza kuti kurapwa kweCAR-T kwakachengeteka kuvarwere ava.
Panyaya yekushanda zvakanaka, pakanga pasina musiyano mukuru mukurarama kusina progression-free survival (PFS) uye kurarama kwese (OS) pakati pemapoka maviri aya, zvichisimbisa kuti kuvapo kwezvirwere zve autoimmune kana kuzvimba hakukanganisi zvakanyanya. Kurapa Kenza mhedzisiro. Zvinofadza kuti, chidzidzo ichi chakaonawo kuvandudzwa mukushanda kwezvirwere zve autoimmune mushure mekurapwa. Kudzikira kukuru kwekudiwa kwemishonga inodzvinyirira immune kwakaonekwa, uye kuputika kwezvirwere kwaisawanzoitika muboka rekurapa.
Chidzidzo ichi chinopa humbowo hwakasimba hunotsigira kushandiswa kwemishonga yeCAR-T muvarwere vane zvirwere zve autoimmune kana kuzvimba panguva imwe chete, zvichiratidza kuti isarudzo inoshanda kune varwere vakawanda vane kenza. Zvakawanikwa izvi zvinokurudzira zvimwe zvidzidzo zvekutsvaga mabhenefiti angangovepo emishonga yeCAR-T muvarwere ava vakasiyana.
Sezvo marapirwo eCAR-T achiramba achichinja, mhedzisiro iyi inopa tariro yekuvandudza nzira dzekurapa nemigumisiro yevarwere vane nhoroondo dzakaoma dzekurapa.