Nhau dzeIndasitiri
Kurapa kweCAR-T Kunokunda Kufungidzira Kusina Kunaka muHigh-Grade B-Cell Lymphoma
Ongororo itsva inoratidza kuti kurapwa kweCAR-T kunogona kuvandudza fungidziro yevarwere vane B-cell lymphoma yepamusoro (HGBL), rudzi rweB-cell lymphoma yakakura, kunyangwe mumitsetse yekurapwa inotevera, zvichipa tariro itsva kune varwere ava vane matambudziko.
Kugadzirisa Matambudziko Enguva Refu Ekurapa kweCAR-T: Ruzivo Kubva kuCancer Yezvisikwa
Chidzidzo chakabudiswa munguva pfupi yapfuura mu Kenza yezvisikwa inoratidza matambudziko enguva refu ekurapwa kweCAR-T cell, ichinyanya kutarisa njodzi dzehutachiona uye kenza yemhando yechipiri, uye inopa nzira dzekuvandudza mhedzisiro yemurwere.
Kukunda Matambudziko muCAR-T Therapy yeT-Cell Blood Cancers
Kunyange hazvo kurapwa neCAR-T kwakachinja kurapa kwegomarara reB-cell, matambudziko makuru achiripo mukurapa gomarara reT-cell. Ongororo ichangobva kuitwa inoongorora kuoma kwekurapa neCAR-T mugomarara reropa reT-cell uye mhinduro dzinogona kutorwa kuti dzikunde zvipingamupinyi izvi.
Kunzwisisa Thalassemia: Gwaro Rakazara reAlfa neBeta Forms
Thalassemia chirwere chinopfuura chimwe chete. Gwaro iri rinoongorora alpha ne beta thalassemia, zvikonzero zvayo, zviratidzo, uye nzira dzekurapa dziripo paBIOOCUS International Medical Center.
Kurapa Masero eNK Kwakasanganiswa Nemushonga weDC Kunoratidza Kuvandudzika Kukuru Mukenza Yechiropa Inosvika Padanho Rekupedzisira
Kubudirira kukuru mukurapa kenza yechiropa yakakwira kwakabuda kuburikidza nemusanganiswa mutsva weNK cell therapy, DC vaccine, uye Nivolumab. Kurapa uku kwakabatana kwe immunotherapy kwakaratidza kubudirira kukuru, zvichikonzera kudzikira kukuru kwebundu uye kuvandudzwa kwebasa rechiropa mumavhiki matanhatu chete kumurwere ane hepatocellular carcinoma iri padanho rekupedzisira.
Kurapa Majini Matsva Kwabudirira Mukurapa Chirwere CheSickle Cell neThalassemia
Munyaya yekutanga yekiriniki, murwere ane makore makumi maviri nerimwe ekuberekwa akakunda matambudziko ethalassemia kuburikidza nekurapa kwemajini kwakavakirwa paCRISPR. Iyi nzira itsva inoratidza danho guru mukurapa zvirwere zvakakomba zveropa zvakaita sechirwere chesickle cell (SCD) nethalassemia.
Kugadzirisa Migumisiro Yekurapa Masero eCAR-T: Pfungwa Huru Kubva Mukutsvagurudza Kwazvino
Nyaya iyi yenhau inoratidza tsvakiridzo yazvino pamusoro pekugadzirisa chepfu dziri muCAR-T cell therapy yeB-cell lymphomas. Chidzidzo ichi chinosimbisa nzira dzekugadzirisa migumisiro yakafanana necytokine release syndrome (CRS) uye neurotoxicity (ICANS), zvichiita kuti kurapwa uku kuve kwakachengeteka.
Kushanda Kwenguva Refu KweCD19 CAR T-Cell Therapy Mukurapa Relapsed/Refractory Acute Lymphoblastic Leukemia
Ongororo itsva inoratidza kubudirira kwenguva refu kwekurapa kweCD19 CAR T-cell mukurapa varwere vane relapse/refractory acute lymphoblastic leukemia (ALL) mushure mekuisirwa allogeneic hematopoietic stem cell transplantation, zvichipa tariro itsva mu hematology.
Kufambira Mberi Mumasero Emuurayi Wechisikigo (NK) Kwemakore Anopfuura 50
Mumakumi mashanu emakore apfuura, tsvakiridzo pamusoro pemasero eNatural Killer (NK) yakachinja kunzwisisa kwedu kwekudzivirira muviri kubva muzvirwere zvemuviri, ichitipa nzira itsva dzinovimbisa dzekurapa kenza nehutachiona.
Kubudirira muChirwere cheAutoimmune muVana: Kurapa kweCAR-T Cell Kunorapa Murwere weLupus
Chidzidzo chekutanga chakaitwa paErlangen University Hospital chakabatsira kurapa musikana ane makore 16 ekuberekwa ane chirwere chakanyanya chesystemic lupus erythematosus (SLE) achishandisa CAR-T cell therapy. Uku ndiko kushandiswa kwekutanga kwekurapa uku kwevana vane lupus, zvichipa tariro itsva kuvana vane zvirwere zve autoimmune.
Kuvandudza Kushanda kwePROTAC: Chidzidzo Chinobaya Mwoyo
Ongororo yakaitwa munguva pfupi yapfuura muNature Communications inoratidza ruzivo rwakakosha munzira dzemukati dzekutumira zviratidzo dzinochinja kushanda kwekuparadzwa kwemapuroteni akanangana nekushandisa maPROTAC. Kuwanikwa uku kunogona kugadzira nzira yekurapa kenza nezvimwe zvirwere zvinobudirira.
Kukurudzira Hutano uye Kupora: Kutarisirwa Kwezuva Nezuva Kwevarwere VeLeukemia
Kuona kuti varwere vane leukemia vanorapwa zvakachengeteka uye zvinonyaradza kunosanganisira kutarisirwa kwakanyatsonaka kwezuva nezuva, kusanganisira kucheneswa kwezvakatipoteredza, hutsanana, kudya kunovaka muviri, uye kurovedza muviri kwakakodzera. Gwaro iri rinopa mazano akakosha ekutarisira zuva nezuva zvinobudirira kuti vatsigire kupora.