Wararka Warshadaha
Daaweynta CAR-T waxay ka gudubtay saadaasha liidata ee Lymphoma-ka Unugga B ee Heerka Sare
Daraasad cusub ayaa muujinaysa in daaweynta CAR-T ay wanaajin karto saadaasha bukaanada qaba lymphoma-ka B-cell ee heerka sare ah (HGBL), oo ah nooc ka mid ah lymphoma-ka B-cell ee waaweyn, xitaa khadadka daaweynta ee dambe, taasoo siinaysa rajo cusub kiisaskan adag.
Maareynta Dhibaatooyinka Muddada Dheer ee Daaweynta CAR-T: Aragtiyo laga helay Kansarka Dabeecadda
Daraasad dhowaan lagu daabacay gudaha Kansarka Dabeecadda Waxay iftiiminaysaa dhibaatooyinka muddada dheer ee daaweynta unugyada CAR-T, iyadoo diiradda saareysa khataraha caabuqyada iyo kansarka labaad, waxayna bixisaa xeelado lagu hagaajinayo natiijooyinka bukaanka.
Ka gudubka Caqabadaha Daaweynta CAR-T ee Kansarka Dhiigga T-Cell
In kasta oo daaweynta CAR-T ay kacaan ku samaysay daaweynta kansarka unugyada B, haddana caqabado muhiim ah ayaa weli ka jira daaweynta kansarka unugyada T. Dib u eegis dhowaan la sameeyay ayaa sahaminaya dhibaatooyinka ka dhasha daaweynta CAR-T ee kansarka unugyada unugyada T iyo xalalka suurtagalka ah ee looga gudbi karo caqabadahaas.
Fahmidda Thalassemia: Hagaha Dhammaystiran ee Qaababka Alpha iyo Beta
Thalassemia waa cudur ka badan hal cudur. Hagahan wuxuu sahaminayaa labadaba alpha iyo beta thalassaemia, sababaha, calaamadaha, iyo ikhtiyaarrada daaweynta ee ugu dambeeyay ee laga heli karo Xarunta Caafimaadka Caalamiga ah ee BIOOCUS.
Daaweynta Unugyada NK oo lagu daray Tallaalka DC waxay muujinaysaa Horumar Laxaad leh oo ku yimid Kansarka Beerka ee Marxaladda Dambe
Horumar laga sameeyay daaweynta kansarka beerka ee horumarsan ayaa soo ifbaxay iyada oo loo marayo isku-darka cusub ee daaweynta unugyada NK, tallaalka DC, iyo Nivolumab. Daaweyntan difaaca jirka ee isku dhafan waxay muujisay guul la taaban karo, taasoo keentay hoos u dhac weyn oo burooyinka ah iyo shaqada beerka oo la hagaajiyay lix toddobaad gudahood bukaan qaba kansarka beerka ee marxaladda dambe.
Daaweynta Hidde-sidayaasha Cusub waxay ku guuleysatay Horumar laga sameeyay Daaweynta Cudurka Sickle Cell iyo Thalassemia
Kiis caafimaad oo hormuud ah, bukaan 21 jir ah ayaa si guul leh uga gudbay caqabadaha thalassaemia iyada oo loo marayo daaweyn hidde-side oo heer sare ah oo ku salaysan CRISPR. Habkan cusub wuxuu calaamad u yahay guul muhiim ah oo laga gaaray daaweynta cudurrada dhiigga ee daran sida cudurka sickle cell (SCD) iyo thalassaemia.
Maareynta Saamaynta Daawaynta Unugyada CAR-T: Aragtiyo Muhiim ah oo laga helay Cilmi-baaristii Dhawaan
Maqaalkan wararka ah wuxuu iftiiminayaa cilmi-baaris dhowaan lagu sameeyay maaraynta sunta daaweynta unugyada CAR-T ee lymphoma-ka unugyada B. Daraasaddu waxay xoogga saareysaa xeeladaha lagu maareeyo waxyeellooyinka caadiga ah sida cudurka sii deynta cytokine (CRS) iyo sunta neerfaha (ICANS), iyadoo la hubinayo in si ammaan ah loo isticmaalo daaweyntan cusub.
Waxtarka Muddada Dheer ee Daaweynta Unugyada T-Cell ee CD19 ee Daaweynta Leukemia Lymphoblastic Ba'an ee Soo Noqnoqotay/Ka-hortagga
Daraasad cusub ayaa muujineysa guusha muddada dheer ee daaweynta unugyada T-cell-ka ee CD19 ee daaweynta bukaanada qaba leukemia-da lymphoblastic ee soo noqnoqda/iska caabbinta leh (ALL) ka dib tallaalka unugyada asliga ah ee hematopoietic, taasoo rajo cusub ka bixinaysa cilmiga dhiigga.
Horumarka Horumarka ee Unugyada Dilaaga Dabiiciga ah (NK) ee ka badan 50 Sano
Shantii sano ee la soo dhaafay, cilmi-baarista ku saabsan unugyada dilaaga dabiiciga ah (NK) ayaa kacaan ku samaysay fahamkeenna ku saabsan difaaca jirka, iyadoo bixinaysa waddooyin cusub oo rajo leh oo loogu talagalay daaweynta kansarka iyo fayraska.
Horumar laga sameeyay Cudurka Is-difaaca Carruurta: Daaweynta Unugyada CAR-T waxay daaweysaa Bukaanka Lupus
Daraasad hormuud ah oo ka dhacday Isbitaalka Jaamacadda Erlangen ayaa si guul leh u daweysay gabar 16 jir ah oo qabta cudurka 'severe systemic lupus erythematosus (SLE)' iyadoo la adeegsanayo daaweynta unugyada CAR-T. Tani waxay calaamad u tahay isticmaalka ugu horreeya ee daaweyntan loogu talagalay lupus-ka carruurta, taasoo rajo cusub u ah carruurta qabta cudurrada difaaca jirka.
Kobcinta Waxtarka PROTAC: Daraasad Aasaasi ah
Daraasad dhowaan lagu sameeyay Nature Communications ayaa shaaca ka qaadaysa aragtiyo muhiim ah oo ku saabsan waddooyinka calaamadaha ee gudaha ee wax ka beddelaya waxtarka burburka borotiinka ee la beegsanayo iyadoo la adeegsanayo PROTACs. Daahfurkani wuxuu u gogol xaarayaa daaweyn waxtar leh oo loogu talagalay kansarka iyo cudurrada kale.
Horumarinta Caafimaadka iyo Soo Kabashada: Daryeelka Maalinlaha ah ee Bukaanada Leukemia
Hubinta waayo-aragnimo daaweyn oo ammaan ah oo raaxo leh oo loogu talagalay bukaanada qaba leukemia waxay ku lug leedahay daryeel maalinle ah oo taxaddar leh, oo ay ku jiraan nadaafadda deegaanka, nadaafadda shaqsiyeed, nafaqada, iyo jimicsi habboon. Tilmaamahan wuxuu bixiyaa talooyin muhiim ah oo ku saabsan daryeel maalinle ah oo wax ku ool ah si loo taageero soo kabashada.