Izindaba Zemboni
Ukwelashwa kwe-CAR-T Kunqoba Ukubikezela Okubi ku-Lymphoma Ye-B-Cell Esezingeni Eliphezulu
Ucwaningo olusha lubonisa ukuthi ukwelashwa kwe-CAR-T kungathuthukisa ukubikezela kweziguli ezine-B-cell lymphoma (HGBL) yebanga eliphezulu, uhlobo lwe-B-cell lymphoma enkulu, ngisho nasemigqeni yokwelashwa kamuva, okunikeza ithemba elisha ngala macala ayinselele.
Ukuphatha Izinkinga Zesikhathi Eside Zokwelashwa Kwe-CAR-T: Ukuqonda Okuvela Kumdlavuza Wemvelo
Ucwaningo lwamuva nje olushicilelwe ku- Umdlavuza Wemvelo iqokomisa izinkinga zesikhathi eside zokwelashwa kwamaseli e-CAR-T, igxile ezingozini zokutheleleka kanye nomdlavuza wesibili, futhi inikeza amasu okuthuthukisa imiphumela yeziguli.
Ukunqoba Izinselele Ekwelashweni Kwe-CAR-T Kwama-T-Cell Blood Cancers
Nakuba ukwelashwa kwe-CAR-T kushintshe kakhulu ukwelashwa komdlavuza we-B-cell, kusenezinselele ezinkulu ekwelapheni umdlavuza we-T-cell. Ukubuyekezwa kwakamuva kuhlola ubunzima bokwelashwa kwe-CAR-T kumdlavuza wegazi we-T-cell kanye nezixazululo ezingaba khona zokunqoba lezi zithiyo.
Ukuqonda i-Thalassemia: Umhlahlandlela Ophelele Wamafomu e-Alpha ne-Beta
I-Thalassemia iyisifo esingaphezu kwesisodwa. Lo mhlahlandlela uhlola i-alpha ne-beta thalassemia, izimbangela zazo, izimpawu, kanye nezinketho zakamuva zokwelapha ezitholakala e-BIOOCUS International Medical Center.
Ukwelashwa Kwamaseli e-NK Kuhlanganiswe Nomuthi Wokugoma we-DC Kubonisa Ukuthuthuka Okumangalisayo Kumdlavuza Wesibindi Osesigabeni Sokugcina
Intuthuko ekwelapheni umdlavuza wesibindi othuthukile ivele ngenhlanganisela entsha yokwelashwa ngamaseli e-NK, umuthi wokugomela i-DC, kanye ne-Nivolumab. Lokhu kwelashwa okuhlanganisiwe kwe-immunotherapy kubonise impumelelo emangalisayo, okuholele ekunciphiseni okukhulu kwesimila kanye nokusebenza kwesibindi okuthuthukisiwe emavikini ayisithupha kuphela esigulini esine-carcinoma yesibindi esesigabeni sokugcina.
Ukwelashwa Okusha Kwezakhi Zofuzo Kufeza Intuthuko Ekwelapheni Isifo Se-Sickle Cell kanye ne-Thalassemia
Esimweni somtholampilo esiphambili, isiguli esineminyaka engu-21 ubudala sanqoba ngempumelelo izinselele ze-thalassemia ngokusebenzisa ukwelashwa kwezakhi zofuzo okusekelwe ku-CRISPR okuthuthukisiwe. Le ndlela entsha iphawula ingqophamlando ebalulekile ekwelapheni izifo ezinkulu zegazi ezifana nesifo se-sickle cell (SCD) kanye ne-thalassemia.
Ukuphatha Imiphumela Engemihle Yokwelashwa Kwamaseli e-CAR-T: Ukuqonda Okubalulekile Ocwaningweni Lwakamuva
Lesi sihloko sezindaba siqokomisa ucwaningo lwakamuva mayelana nokuphatha ubuthi bokwelashwa kwamaseli e-CAR-T kuma-B-cell lymphomas. Ucwaningo lugcizelela amasu okusingatha imiphumela emibi evamile njenge-cytokine release syndrome (CRS) kanye ne-neurotoxicity (ICANS), okuqinisekisa ukusetshenziswa okuphephile kwalokhu kwelashwa okusha.
Ukusebenza Kwesikhathi Eside Kokwelashwa Kwe-CD19 CAR T-Cell Ekwelapheni I-Relapsed/Refractory Acute Lymphoblastic Leukemia
Ucwaningo oluqavile lubonisa impumelelo yesikhathi eside yokwelashwa kwe-CD19 CAR T-cell ekwelapheni iziguli ezine-relapse/refractory acute lymphoblastic leukemia (ALL) ngemuva kokufakelwa kwe-allogeneic hematopoietic stem cell, okunikeza ithemba elisha ku-hematology.
Intuthuko Ethuthukisiwe Kumaseli Okubulala Ngokwemvelo (NK) Eminyakeni Engaphezu Kwengu-50
Eminyakeni engamashumi amahlanu edlule, ucwaningo ngamaseli e-Natural Killer (NK) lushintshe ukuqonda kwethu ngokuzivikela komzimba okungokwemvelo, lunikeza izindlela ezintsha ezithembisayo zokwelapha umdlavuza kanye negciwane.
Ukuphumelela Kwesifo Sokuzivikela Kwezingane Ezizimele: Ukwelashwa Kwamaseli e-CAR-T Kwelapha Isiguli Se-Lupus
Ucwaningo oluqavile e-Erlangen University Hospital lwelapha ngempumelelo intombazane eneminyaka engu-16 ubudala ene-systemic lupus erythematosus (SLE) enzima kusetshenziswa ukwelashwa ngamaseli e-CAR-T. Lokhu kuphawula ukusetshenziswa kokuqala kwalokhu kwelashwa kwe-lupus yabantwana, okunikeza ithemba elisha ezinganeni ezinezifo ezizimele.
Ukuthuthukisa Ukusebenza Kahle Kwe-PROTAC: Ucwaningo Oluqabulayo
Ucwaningo lwakamuva ku-Nature Communications lwembula ukuqonda okubalulekile ngezindlela zokubonisana zangaphakathi ezilawula ukusebenza kahle kokuwohloka kwamaprotheni okuqondiwe kusetshenziswa ama-PROTAC. Lokhu kutholakala kungavula indlela yokwelashwa okuphumelelayo kakhulu komdlavuza nezinye izifo.
Ukukhuthaza Impilo Nokululama: Ukunakekelwa Kwansuku Zonke Kweziguli Ezine-Leukemia
Ukuqinisekisa ukuthi iziguli ezine-leukemia zithola ukwelashwa okuphephile nokukhululekile kuhilela ukunakekelwa kwansuku zonke ngokucophelela, okuhlanganisa ukuhlanzeka kwemvelo, inhlanzeko yomuntu siqu, ukudla okunempilo, kanye nokuzivocavoca okufanele. Lo mhlahlandlela unikeza amathiphu abalulekile okunakekelwa kwansuku zonke okuphumelelayo ukusekela ukululama.