Kugadzirisa Migumisiro Yekurapa Masero eCAR-T: Pfungwa Huru Kubva Mukutsvagurudza Kwazvino

Chidzidzo chakabudiswa munguva pfupi yapfuura mu Oncology yeHematologicalinojekesa nzira dzekurapa chepfu dzine chekuita neChimeric Antigen Receptor (CAR) T-cell therapy, mushonga unochinja-chinja we B-Cell Lymphomas. Kunyange hazvo kurapwa neCAR-T kwakaratidza kubudirira kukuru mukurapa lymphoma yeB-cell yakakura inodzokera shure kana kuti isingadzoreki, kunounzawo matambudziko makuru nekuda kwemigumisiro yakakomba.

Chidzidzo ichi, chinotungamirwa naDr. S. Neelapu, chinotarisa pazvinhu zviviri zvinonyanya kukonzera chepfu zvinoonekwa neCAR-T therapy: cytokine release syndrome (CRS) uye immune effector cell-associated neurotoxicity syndrome (ICANS). Chepfu idzi dzinowanzoitika nguva pfupi mushure mekuiswa muCAR-T uye dzinoda kurapwa nekukurumidza kudzivirira matambudziko akakomba. CRS inowanzo ratidza fivha, BP yakaderera, uye matambudziko ekufema, nepo ICANS ichigona kutungamira mukuvhiringidzika, pfari, uye mune zviitiko zvakakomba, coma.

Chinyorwa ichi chinosimbisa kukosha kwekuzivikanwa nekukurumidza uye kuongororwa kwechepfu idzi kuti pave nenzira dzakakodzera dzekurapa. Chinotaurawo nezvekushandiswa kwemishonga yakadai setocilizumab yeCRS uye corticosteroids yeICANS, iyo yakaratidza kushanda mukuderedza izvi zvinogona kutyisidzira hupenyu.

Uyezve, mushumo uyu unoongorora chepfu dzinogara kwenguva refu, kusanganisira cytopenia dzinotora nguva refu (kudzikira kwehuwandu hwemasero eropa) uye migumisiro yakanangana nebundu, iyo inoda kutariswa nekutarisirwa nguva dzose. Chidzidzo ichi chinosimbisa kuti, kunyangwe kurapwa kweCAR-T kuchikwanisa zvikuru, varapi vehutano vanofanirwa kunge vakagadzirira kubata migumisiro yaro yakasiyana uye yakakomba.

Nekuyedzwa kwekiriniki kuri kuenderera mberi uye zvinhu zvitsva, munda uyu unoramba uchigadzira nzira dziri nani dzekugadzirisa chepfu idzi, zvichibvumira kurapa kweCAR-T kushandiswa zvakachengeteka uye zvinobudirira.