Gucunga ingaruka mbi zo kuvura uturemangingo twa CAR-T: Ibisobanuro by'ingenzi byavuye mu bushakashatsi buherutse gukorwa

Ubushakashatsi buherutse gusohoka muri Ubumenyi bw'indwara z'amarasoiragaragaza uburyo bwo gucunga uburozi bujyanye no kuvura selile za T zikoresha Chimeric Antigen Receptor (CAR), uburyo bushya bwo kuvura Lymphoma y'uturemangingo twa BNubwo ubuvuzi bwa CAR-T bwagaragaje ko bufite icyo bugeraho mu kuvura lymphoma nini ya B-cell B yasubiwemo cyangwa idashobora kuvura, bunazana imbogamizi zikomeye bitewe n’ingaruka zikomeye.

Ubu bushakashatsi, buyobowe na Dr. S. Neelapu, bwibanze ku bintu bibiri bikunze kugaragara mu kuvura CAR-T: cytokine release syndrome (CRS) na immunoeffector cell-associated neurotoxicity syndrome (ICANS). Ubu burozi bukunze kubaho nyuma gato yo guterwa CAR-T kandi bugasaba ko umuntu yihutira kubufata kugira ngo hirindwe ingorane zikomeye. CRS ikunze kugaragaza umuriro, umuvuduko muke w'amaraso, n'ingorane zo guhumeka, mu gihe ICANS ishobora gutera urujijo, gucika intege, no mu bihe bikomeye, koma.

Iyi nkuru igaragaza akamaro ko kumenya no gupima ubu burozi hakiri kare kugira ngo hakorwe ingamba zikwiye zo kuvura. Ivuga kandi ku ikoreshwa ry'imiti nka tocilizumab kuri CRS na corticosteroids kuri ICANS, byagaragaye ko bigira ingaruka nziza mu kugabanya ubu burwayi bushobora gushyira ubuzima mu kaga.

Byongeye kandi, raporo isuzuma uburozi bw'igihe kirekire, harimo kugabanuka kw'uturemangingo tw'amaraso mu maraso (cytopenia) n'ingaruka zabyo, zitari iza kanseri, zisaba gukomeza gukurikiranwa no gucungwa. Ubushakashatsi bushimangira ko, nubwo ubuvuzi bwa CAR-T bufite ubushobozi bunini, abakora mu buvuzi bagomba kuba bafite ibikoresho byo guhangana n'ingaruka mbi zidasanzwe kandi zikomeye.

Hamwe n'igeragezwa ry'ubuvuzi rikomeje n'udushya, uru rwego rukomeje gushyiraho ingamba nziza zo guhangana n'ubu burozi, bigatuma ubuvuzi bwa CAR-T bukoreshwa mu buryo bwizewe kandi bunoze.