Kurapa Masero eNK Kwakasanganiswa Nemushonga weDC Kunoratidza Kuvandudzika Kukuru Mukenza Yechiropa Inosvika Padanho Rekupedzisira
Kubudirira kwezvekurapa munguva pfupi yapfuura mu Kurapa nekudzivirira muviri inopa tariro itsva kuvarwere vane kenza yechiropa iri padanho rekupedzisira, kunyanya avo vane nzira shoma dzekurapa. Munyaya inoshamisa kubva kuJapan, murwere ane chirwere che advanced hepatocellular carcinoma (HCC) akagamuchira mushonga mutsva wakabatanidzwa unosanganisira natural killer cells (NK), dendritic cell vaccines (DC), uye Nivolumab, zvichikonzera kuvandudzika kunoshamisa mumavhiki matanhatu chete.
Murwere uyu, akaonekwa aine HCC padanho rekupedzisira uye akapararira muma lymph nodes, mapapu, nemapfupa, akanga asina tarisiro yakanaka yekurapwa netsika. Nekusashanda zvakanaka kwechiropa, huwandu hwema lymphocyte hwakaderera, uye huwandu hushoma hwechiropa, timu yake yezvekurapa yakanga isina sarudzo dzakawanda. Vakatanga chirongwa chakazara chekurapa nekudzivirira muviri, chakabatanidza majekiseni eDC neNivolumab ne Nk Cell kurapwa kunopihwa mavhiki matatu ega ega mumatanho matatu.
Zvinoshamisa kuti, mushure memavhiki matanhatu chete ekurapwa, mashandiro echiropa chemurwere akavandudzika zvikuru, achibva muchikamu cheC cheChild-Pugh (chakaderera zvikuru) kuenda kuA (mamiriro ezvinhu ane hutano hwakanaka). Kuchinja uku kwakabatana nekudzikira kukuru kwehukuru hwegomarara, kunyangarika kweascites, uye kudzikira kwezviratidzo zvegomarara.
Masero eNK, kana kuti masero anouraya echisikigo, rudzi rwemasero ekudzivirira muviri ane kugona kwekuzvarwa nako kuona nekuparadza masero asina kujairika, akadai semasero ekenza, pasina chikonzero chekudzidziswa kwekutanga. Izvi zvinoita kuti ashande zvakanyanya mukurwisa nekukurumidza nekubvisa masero ekenza. Zvisinei, kune varwere vane chirwere chisingaperi kana kenza yepamusoro, kushanda kwemasero eNK kunogona kukanganiswa. Kuti vagadzirise izvi, vaongorori vakagadzira nzira dzekuvandudza mashandiro emasero eNK kuburikidza nekugadzira majini uye kurapwa kwakabatana.
Muchiitiko ichi, kurapwa nemasero eNK kwakabatana nejekiseni reDC, rakagadzirirwa kumutsa immune system yemurwere, uye Nivolumab, chinhu chinodzivirira kenza kudzivirira immune system yemurwere. Pakazosvika nguva yekurapwa yechitanhatu, CT scans yakaratidza kudzikira kukuru kwehukuru hwegomarara, uye mamiriro emurwere ese akavandudzika zvakakwana kuti achinje kuenda kune yakajairika chemotherapy regimen. Zvakabuda murabhoritari zvakaratidzawo kudzikira kwakakosha kwezviratidzo zvegomarara, kusanganisira vitamin K deficiency-induced protein-Ⅱ (PIVKA-II), uye kudzorerwa kwehuwandu hwemasero machena eropa uye lymphocyte levels yemurwere.
Nyaya iyi inoratidza kuti kurapwa nezvirwere zvemuviri, kunyanya kurapwa nemasero eNK, kunogona kubatsira sei varwere vane kenza yepamusoro vane nzira shoma dzekurapa. Kubatanidzwa kwakabudirira kwemasero eNK nemamwe masero ekudzivirira chirwere akadai seDC vaccines uye checkpoint inhibitors kunovhura mukana wemikana mitsva yekurapa kenza, kunyanya kune avo vanoonekwa sevasingakwanise kurapwa kana kuti vasina kutsungirira kurapwa kwakasimba.
Kugona kweNK cell therapy kugadzirisa maitiro ekurapa kenza hakugone kupfuudzwa zvakanyanya. Hazvingopi chete nzira yehupenyu kune varwere vane sarudzo shoma dzasara, asiwo zvinovhura nzira yekufambira mberi mune ramangwana mumishonga yakagadzirirwa munhu uye mishonga inodzivirira hutachiona. Kunyange zvazvo nyaya iyi ichipa tariro, inoratidzawo kudiwa kwekuenderera mberi nekutsvaga kuti mishonga iyi inobudirira ive nyore kuwana uye ive yakajairika kune varwere vakawanda.
Sezvo nyaya yekurapa nekudzivirira chirwere ichi ichiramba ichichinja, nyaya iyi inoratidza mukana mukuru wekuti mishonga yekudzivirira chirwere ichi inogona kushandura ramangwana rekurapa kenza.