Maganin Kwayoyin Halitta na NK da aka haɗa tare da allurar rigakafin DC ya nuna babban ci gaba a cikin cutar kansar hanta ta ƙarshe

Wani ci gaba na likitanci kwanan nan a cikin Maganin rigakafi yana ba da sabuwar fata ga marasa lafiya da ke fama da cutar kansar hanta ta ƙarshe, musamman waɗanda ke da ƙarancin zaɓuɓɓukan magani. A cikin wani lamari mai ban mamaki daga Japan, wani majiyyaci da ke fama da cutar kansar hanta mai ci gaba (HCC) ya sami sabuwar hanyar magani ta haɗin gwiwa da ta ƙunshi ƙwayoyin kisa na halitta (NK), alluran rigakafin ƙwayoyin dendritic (DC), da Nivolumab, wanda ya haifar da ci gaba mai ban mamaki cikin makonni shida kacal.

Majinyacin, wanda aka gano yana da cutar HCC a ƙarshen mataki da kuma yaduwar ƙwayoyin lymph, huhu, da ƙashi, bai yi hasashen maganin gargajiya ba. Tare da matsanancin aikin hanta, ƙarancin adadin ƙwayoyin lymph, da ƙarancin ajiyar hanta, ƙungiyar likitocinsa ba ta da zaɓuɓɓuka da yawa. Sun fara tsarin rigakafi mai cikakken tsari, wanda ya haɗa alluran rigakafin DC tare da Nivolumab da Nk Cell maganin da ake bayarwa duk bayan makonni uku a tsawon zagaye uku.

Abin mamaki, bayan makonni shida kacal na magani, aikin hanta na majiyyaci ya inganta sosai, inda ya koma daga rarrabuwar Child-Pugh ta C (mafi ƙanƙanta) zuwa A (yanayin lafiya mai kyau). Wannan sauyi ya kasance tare da raguwar girman ƙari, ɓacewar ascites, da raguwar alamun ƙari.

Kwayoyin NK, ko ƙwayoyin halitta masu kisa, nau'in ƙwayoyin garkuwar jiki ne mai ikon ganowa da lalata ƙwayoyin halitta marasa kyau, kamar ƙwayoyin cutar kansa, ba tare da buƙatar horo na gaba ba. Wannan yana sa su yi tasiri sosai wajen kai hari da kuma kawar da ƙwayoyin ƙari cikin sauri. Duk da haka, a cikin marasa lafiya da ke fama da cututtuka na yau da kullun ko kuma waɗanda suka kamu da cutar kansa, ingancin ƙwayoyin NK na iya yin rauni. Don magance wannan, masu bincike sun ƙirƙiro hanyoyin haɓaka ayyukan ƙwayoyin NK ta hanyar injiniyan kwayoyin halitta da hanyoyin haɗin gwiwa.

A wannan yanayin, an haɗa maganin ƙwayoyin NK tare da allurar rigakafin DC, wanda aka tsara don kunna tsarin garkuwar jiki na majiyyaci, da kuma Nivolumab, wani maganin da ke hana kamuwa da cutar kansa daga amsawar garkuwar jiki. A zagaye na shida na magani, gwajin CT ya nuna raguwar girman ƙari, kuma yanayin majiyyaci ya inganta sosai har ya canza zuwa tsarin chemotherapy na yau da kullun. Sakamakon dakin gwaje-gwaje ya kuma nuna raguwar alamun ƙari, gami da furotin-Ⅱ da ƙarancin bitamin K ke haifarwa (PIVKA-II), da kuma dawo da adadin ƙwayoyin jinin majiyyaci da matakan ƙwayoyin lymphocytes.

Wannan lamari wata alama ce mai kyau ta yadda maganin rigakafi, musamman magungunan da aka yi amfani da su a ƙwayoyin NK, za su iya zama mafita ga marasa lafiya da ke fama da cutar kansar da ta yi tsanani waɗanda ke da ƙarancin zaɓuɓɓukan magani na gargajiya. Nasarar haɗa ƙwayoyin NK tare da wasu magungunan rigakafi kamar alluran rigakafi na DC da masu hana wuraren bincike suna buɗe ƙofa ga sabbin damarmaki na maganin ciwon daji, musamman ga waɗanda ake ganin ba za a iya yi musu aiki ba ko kuma waɗanda ba su da haƙurin magani.

Ba za a iya ƙara faɗi game da yuwuwar maganin ƙwayoyin NK don sake fasalin ka'idojin maganin cutar kansa ba. Ba wai kawai yana ba da damar rayuwa ga marasa lafiya waɗanda ke da 'yan zaɓuɓɓuka kaɗan ba, har ma yana share hanyar ci gaba a nan gaba a cikin magunguna na musamman da hanyoyin magance rigakafi. Duk da cewa wannan shari'ar tana ba da ɗan haske game da bege, yana kuma nuna buƙatar ci gaba da bincike don tabbatar da cewa waɗannan hanyoyin magance cutar sun zama mafi sauƙin samu da daidaito ga yawancin marasa lafiya.

Yayin da fannin maganin rigakafi ke ci gaba da bunkasa, wannan shari'ar ta zama shaida ga babban ƙarfin da magungunan da aka yi amfani da su wajen magance cutar kansa ke da shi.