Maganin CAR-T don Ciwon Neuroblastoma Mai Lalacewa/Mai Rage Radadi

Maganin GD2 CAR-Twani sabon maganin rigakafi ne wanda ke gyara ƙwayoyin T na majiyyaci ta hanyar halitta don gane da kuma kai hari ga ƙwayoyin neuroblastoma da ke bayyana antigen na GD2. An tsara wannan maganin musamman ga marasa lafiya da ke fama da cutar neuroblastoma mai haɗari mai sake dawowa ko kuma mai jurewa kuma ya nuna sakamako mai kyau na asibiti a gwaje-gwaje.

• Matsayin Cutar: Ciwon neuroblastoma mai haɗari sosai tare da ci gaba da cutar, sake dawowa, ko ci gaba bayan maganin farko.

• Ƙarin Abubuwan: Cututtukan da suka shafi ƙashi, faɗaɗa MYCN, ko kuma juriya ga magungunan gargajiya.

Matakai Masu Mahimmanci

1. Sharaɗin da aka riga aka yi: Ciwon Lymph kafin a yi amfani da shi.

2. Jiko: Daidaiton allurar ƙwayoyin GD2-CAR-T (an ba da shawarar: 10×10^6 ƙwayoyin T masu CAR-positive/kg).

3. Mai bibiya: Hoto na yau da kullun (PET/CT, MRI) da kimantawar ƙashi bayan allurar.

Sakamakon Asibiti

• Yawan Amsawa: Kashi 33% sun sami cikakkiyar gafara (CR), tare da jimlar amsawar (CR+PR) na 63%.

• Rayuwa: Jimlar rayuwa ta shekaru 3 (OS) na kashi 60% da kuma rayuwa ba tare da wani abu ba (EFS) na kashi 36% a adadin da aka ba da shawarar.

• Bayanin TsaroMafi yawan abubuwan da suka faru marasa kyau sune cututtukan sakin cytokine na aji 1-2 (74%).

Amfaninmu

• MARA TA ƙarni na 3: Yankunan haɗin gwiwa guda biyu (CD28 + 4-1BB) suna haɓaka ƙarfin ƙwayoyin T da juriya.

• Maɓallin Tsaro: Haɗaɗɗen kwayar halittar iC9 tana ba da damar sarrafa guba cikin sauri idan ana buƙata.

• Tabbataccen Tarihin WaƙoƙiNasarar da aka nuna a gwaje-gwajen asibiti tare da ingantattun bayanai na bin diddigin lokaci mai tsawo.