Hōʻike ka NK Cell Therapy i hui pū ʻia me ka DC Vaccine i ka hoʻomaikaʻi nui ʻana i ka maʻi kanesa o ke akepaʻa hope loa

He holomua lapaʻau hou loa i loko Hoʻōla lāʻau pale hāʻawi i ka manaʻolana hou no nā poʻe maʻi me ke kanesa ate hope loa, ʻoiai ka poʻe me nā koho lapaʻau palena ʻole. Ma kahi hihia hou mai Iapana, ua loaʻa i kahi mea maʻi e ʻeha nei i ka hepatocellular carcinoma holomua (HCC) kahi lāʻau lapaʻau i hui pū ʻia e pili ana i nā cell pepehi kanaka kūlohelohe (NK), nā lāʻau pale cell dendritic (DC), a me Nivolumab, e hopena ana i kahi hoʻomaikaʻi kupaianaha i loko o ʻeono pule wale nō.

ʻO ka mea maʻi, i ʻike ʻia me ka HCC hope loa a me nā metastases ākea i nā lymph nodes, nā māmā, a me nā iwi, he prognosis maikaʻi ʻole me nā lāʻau lapaʻau kuʻuna. Me ka hana koʻikoʻi o ke akepaʻa, ka helu lymphocyte haʻahaʻa, a me ka mālama ʻana i ke akepaʻa liʻiliʻi, ʻaʻohe koho o kāna hui lapaʻau. Ua hoʻomaka lākou i kahi regimen immunotherapy piha, kahi i hoʻohui pū i nā lāʻau pale DC me Nivolumab a me Kelepona Nk hoʻokele ʻia ka lāʻau lapaʻau i kēlā me kēia ʻekolu pule ma o ʻekolu mau pōʻaiapuni.

ʻO ka mea kupanaha, ma hope o ʻeono pule wale nō o ka mālama ʻana, ua holomua nui ka hana o ke akepaʻa o ka mea maʻi, e neʻe ana mai kahi hoʻonohonoho Child-Pugh o C (ka haʻahaʻa loa) a i A (kahi kūlana olakino maikaʻi loa). Ua hele pū ʻia kēia hoʻololi ʻana me ka emi nui ʻana o ka nui o ka puʻupuʻu, ka nalo ʻana o nā ascites, a me ka emi ʻana o nā māka puʻupuʻu.

ʻO nā pūnaewele NK, a i ʻole nā ​​pūnaewele pepehi kanaka kūlohelohe, he ʻano pūnaewele pale me ka hiki ke ʻike a luku i nā pūnaewele ʻē, e like me nā pūnaewele maʻi kanesa, me ka ʻole o ka hoʻomaʻamaʻa mua. ʻO kēia ka mea e lilo ai lākou i mea kūpono loa i ka hoʻopaʻa wikiwiki ʻana a me ka hoʻopau ʻana i nā pūnaewele tumor. Eia nō naʻe, i nā poʻe maʻi me ka maʻi mau a i ʻole nā ​​​​maʻi kanesa holomua, hiki ke hoʻopilikia ʻia ka pono o nā pūnaewele NK. No ka hoʻoponopono ʻana i kēia, ua hoʻomohala nā mea noiʻi i nā ala e hoʻonui ai i ka hana o nā pūnaewele NK ma o ka ʻenekinia genetic a me nā lāʻau lapaʻau hui pū ʻia.

I kēia hihia, ua hui pū ʻia ka lāʻau lapaʻau NK cell me kahi lāʻau pale DC, i hoʻolālā ʻia e hoʻoulu i ka ʻōnaehana pale o ka mea maʻi, a me Nivolumab, kahi mea pale checkpoint e ālai ana i ka hiki o ke kanesa ke pale aku i nā pane pale. Ma ke ono o ke kaʻina hana lapaʻau, ua hōʻike nā scan CT i ka emi nui ʻana o ka nui o ka puʻupuʻu, a ua lawa ka maikaʻi o ke kūlana holoʻokoʻa o ka mea maʻi e hoʻololi i kahi regimen chemotherapy maʻamau. Ua hōʻike pū nā hopena o ka hale hana i ka emi ʻana o nā māka puʻupuʻu, me ka protein-Ⅱ i hoʻokomo ʻia i ka hemahema o ka huaora K (PIVKA-II), a me ka hoʻihoʻi ʻana o ka helu o nā cell koko keʻokeʻo a me nā pae lymphocyte o ka mea maʻi.

He hōʻailona hoʻohiki kēia hihia no ke ʻano o ka immunotherapy, ʻoiai nā lāʻau lapaʻau NK, hiki ke lilo i ola no nā poʻe maʻi me nā maʻi kanesa holomua i loaʻa nā koho lapaʻau maʻamau. ʻO ka hui pū ʻana o nā cell NK me nā immunotherapies ʻē aʻe e like me nā lāʻau pale DC a me nā mea pale checkpoint e wehe i ka puka i nā mea hiki ke hana hou no ka mālama ʻana i ka maʻi kanesa, ʻoi aku hoʻi no ka poʻe i manaʻo ʻia he hiki ʻole ke hana a i ʻole me ka hoʻomanawanui haʻahaʻa.

ʻAʻole hiki ke hoʻonui ʻia ka hiki o ka lāʻau lapaʻau NK cell ke hoʻoponopono hou i nā kaʻina hana lapaʻau maʻi kanesa. ʻAʻole ia e hāʻawi wale i kahi laina ola no nā poʻe maʻi me nā koho liʻiliʻi i koe, akā hoʻomākaukau pū i ke ala no nā holomua i ka wā e hiki mai ana i ka lāʻau lapaʻau pilikino a me nā lāʻau lapaʻau e pili ana i ka pale ʻana. ʻOiai ke hāʻawi nei kēia hihia i kahi ʻike o ka manaʻolana, hōʻike pū ia i ka pono no ka noiʻi e hoʻomau nei e hōʻoia i ka maʻalahi o kēia mau lāʻau lapaʻau hou a me ke kūlana maʻamau no ka heluna kanaka maʻi ākea.

I ka hoʻomau ʻana o ka ulu ʻana o ke kahua o ka immunotherapy, lawelawe kēia hihia ma ke ʻano he hōʻike i ka nui o ka hiki ke loaʻa i nā lāʻau lapaʻau e pili ana i ka pale ʻana no ka hoʻololi ʻana i ka wā e hiki mai ana o ka mālama ʻana i ka maʻi kanesa.