He whakapainga nui te whakaora pūtau NK me te kano ārai mate DC i roto i te mate pukupuku ate i te wāhanga mutunga
He putanga hou i roto i te rongoā Te rongoā ārai mate He tumanako hou tēnei mō ngā tūroro e pāngia ana e te mate pukupuku ate kua tata te mutunga, inā koa ko te hunga he iti noa ngā whiringa maimoatanga. I roto i tētahi take hou mai i Hapani, i whiwhi tētahi tūroro e pāngia ana e te mate pukupuku ate kua horapa haere (HCC) i tētahi maimoatanga whakakotahi auaha e whakauru ana i ngā pūtau whakamate taiao (NK), ngā kano kano pūtau dendritic (DC), me Nivolumab, ā, i hua ake he whakapainga whakamiharo i roto i ngā wiki e ono noa iho.
Ko te tūroro, i kitea he HCC wāhanga mutunga me te horapa o te mate ki ngā kōpū lymph, ngā pukahukahu, me ngā wheua, he kino te āhua o tōna oranga me ngā maimoatanga tuku iho. Nā te kino o te mahi ate, te iti o te maha o ngā lymphocyte, me te iti o te rahui ate, he iti noa ngā kōwhiringa a tana tīma hauora. I tīmatahia e rātou he tikanga rongoā ārai mate whānui, i whakakotahi i ngā kano kano DC me Nivolumab me Pūtau Nk ka tukuna te rongoā i ia wiki e toru mō ngā huringa e toru.
He mea whakamiharo, i muri i ngā wiki e ono noa o te maimoatanga, i tino pai ake te mahi a te ate o te tūroro, mai i te whakarōpūtanga Child-Pugh o C (te iti rawa) ki te A (he āhua hauora ake). I haere tahi tēnei panonitanga me te whakahekenga nui o te rahi o te pukupuku, te ngaronga o ngā ascites, me te hekenga o ngā tohu pukupuku.
Ko ngā pūtau NK, arā, ngā pūtau whakamate tūturu, he momo pūtau ārai mate kei roto te kaha ki te kite me te whakangaro i ngā pūtau rerekē, pērā i ngā pūtau matepukupuku, me te kore e hiahiatia he whakangungu o mua. Nā tēnei ka tino whai hua rātou ki te aro tere me te whakakore i ngā pūtau pukupuku. Heoi, i roto i ngā tūroro he mate pūmau, he matepukupuku kua whanake haere rānei, ka taea te whakararu i te whai huatanga o ngā pūtau NK. Hei whakatika i tēnei, kua whakawhanakehia e ngā kairangahau he huarahi hei whakarei ake i te mahi a ngā pūtau NK mā te hangarau ira me ngā maimoatanga whakakotahi.
I tēnei take, i honoa te rongoā pūtau NK me te kano kano DC, i hangaia hei whakahohe i te pūnaha ārai mate o te tūroro, me te Nivolumab, he aukati tirotiro e aukati ana i te kaha o te mate pukupuku ki te karo i ngā urupare ārai mate. I te ono o ngā huringa maimoatanga, i whakaatuhia e ngā karapa CT he hekenga nui o te rahi o te pukupuku, ā, i pai ake te āhua whānui o te tūroro ki te neke ki te tikanga chemotherapy paerewa. I whakaatuhia hoki e ngā hua taiwhanga he hekenga nui o ngā tohu pukupuku, tae atu ki te pūmua-2 i puta mai i te ngoikore o te huaora K (PIVKA-II), me te whakahokinga mai o te maha o ngā toto toto ma me ngā taumata lymphocyte o te tūroro.
He tohu pai tēnei mō te āhua o te whakaora ārai mate, inā koa ngā maimoatanga e ahu mai ana i ngā pūtau NK, hei oranga mō ngā tūroro e pāngia ana e te mate pukupuku kua pāngia e te mate pukupuku kua matatau, engari he iti noa ngā whiringa maimoatanga tuku iho. Mā te whakakotahitanga angitu o ngā pūtau NK me ētahi atu whakaora ārai mate pērā i ngā kano kano DC me ngā aukati tirotiro ka huaki te kuaha ki ngā mea hou mō te maimoatanga mate pukupuku, inā koa mō te hunga e kiia ana kāore e taea te mahi, he iti rānei te manawanui ki te maimoatanga.
Kāore e taea te whakanui rawa i te kaha o te rongoā pūtau NK ki te whakahou i ngā tikanga maimoatanga mate pukupuku. Ehara i te mea he oranga mō ngā tūroro he iti noa ngā kōwhiringa e toe ana, engari ka whakatakoto hoki i te ara mō ngā whanaketanga ā muri ake nei i roto i te rongoā whaiaro me ngā maimoatanga e ahu mai ana i te ārai mate. Ahakoa he tirohanga tumanako tēnei take, e whakaatu ana hoki i te hiahia mō te rangahau tonu kia māmā ake ai te uru atu me te paerewa o ēnei maimoatanga hou mō te taupori tūroro whānui.
I te whanaketanga tonu o te mara o te whakaora ārai mate, he tohu tēnei kēhi i te kaha nui o ngā maimoatanga e ahu mai ana i te ārai mate hei whakarerekē i te heke mai o te tiaki mate pukupuku.