Hōʻike ka CAR-T Therapy i ka palekana a me ka pono i nā poʻe maʻi kanesa me nā maʻi Autoimmune a i ʻole Inflammatory

Ma kahi noiʻi hou i paʻi ʻia ma ʻO ka Lancet Rheumatology, ua loiloi nā mea noiʻi mai ka Dana-Farber Cancer Institute i ka palekana a me ka pono o ka lāʻau lapaʻau CAR-T i nā poʻe maʻi kanesa me ka mōʻaukala o nā maʻi autoimmune a i ʻole nā ​​​​maʻi mumū. ʻO ke aʻo ʻana, nāna i loiloi i ka ʻikepili mai 2017 a i 2023, ua komo pū me 604 mau maʻi me ka lymphoma a me ʻO ka Myeloma lehulehu, nona he 53 o lākou i loaʻa i nā maʻi autoimmune a i ʻole nā ​​​​​​maʻi mumū. ʻO kēia mau kūlana i komo pū me nā maʻi rheumatoid, me ka psoriasis ka mea maʻamau.

Ua hōʻike ka lāʻau lapaʻau CAR-T cell, e kuhikuhi pono ana iā CD19 a me BCMA, i ka holomua kupaianaha i ka mālama ʻana i ka relapsed a me ka refractory. Lymphoma Pūnaewele B, leukemia, a me ka myeloma maha. Eia nō naʻe, ua kū mai nā hopohopo e pili ana i kona palekana a me ka pono i nā poʻe maʻi me nā maʻi autoimmune a i ʻole nā ​​​​maʻi mumū mua, ʻoiai ʻoi aku ka nui o ka pilikia o kēia mau poʻe maʻi no nā hopena koʻikoʻi e like me ka cytokine release syndrome (CRS) a me ka immune effector cell-associated neurotoxicity syndrome (ICANS).

Ua ʻike ʻia ma ke aʻo ʻana ua like ka nui o CRS a me ICANS i nā poʻe maʻi me nā maʻi autoimmune a i ʻole nā ​​maʻi mumū me nā poʻe maʻi me ka ʻole o kēia mau kūlana. ʻO ke kikoʻī, ua liʻiliʻi nā helu o CRS koʻikoʻi, me ka ʻole o ka ʻokoʻa koʻikoʻi ma waena o nā hui ʻelua. Ua like pū ka nui o ICANS, e hōʻike ana he palekana ka lāʻau lapaʻau CAR-T no kēia mau poʻe maʻi.

Ma ke ʻano o ka pono, ʻaʻohe ʻokoʻa koʻikoʻi ma ke ola ʻole o ka holomua (PFS) a me ke ola holoʻokoʻa (OS) ma waena o nā hui ʻelua, e hōʻoia hou ana ʻaʻole i hoʻopilikia maikaʻi ʻole ka loaʻa ʻana o nā maʻi autoimmune a i ʻole nā ​​​​maʻi mumū i ka Ka Lapaʻau ʻana i ka Maʻi ʻAʻai nā hopena. ʻO ka mea hoihoi, ua ʻike pū ka noiʻi i nā hoʻomaikaʻi ʻana i ka hana maʻi autoimmune ma hope o ka mālama ʻana. Ua ʻike ʻia ka emi nui ʻana o ka pono no nā immunosuppressants, a ʻaʻole i pinepine ka piʻi ʻana o ka maʻi i ka hui mālama ʻia.

Hāʻawi kēia haʻawina i nā hōʻike paʻa e kākoʻo ana i ka hoʻohana ʻana i ka lāʻau lapaʻau CAR-T i nā poʻe maʻi me nā maʻi autoimmune a i ʻole nā ​​​​maʻi mumū e like me ia, e hōʻike ana he koho kūpono ia no kahi ākea o nā maʻi maʻi kanesa. Paipai nā ʻike i nā haʻawina hou aʻe e ʻimi i nā pono kūpono o ka lāʻau lapaʻau CAR-T i kēia heluna kanaka maʻi kū hoʻokahi.

I ka hoʻomau ʻana o ka ulu ʻana o nā lāʻau lapaʻau CAR-T, hāʻawi kēia mau hopena i ka manaʻolana no ka hoʻomaikaʻi ʻana i nā koho lapaʻau a me nā hopena no nā maʻi me nā moʻolelo lapaʻau paʻakikī.