ʻO ka lāʻau lapaʻau CAR-T no ka Myeloma Multiple (MM)

ʻO ka Multiple Myeloma (MM) kahi ʻano maʻi ʻaʻai e hoʻopilikia i nā cell plasma i loko o ka iwi iwi. Ua ʻike ʻia no kona ʻano paʻakikī a loli pinepine, e hopena pinepine ana i nā relapses a me ke kūʻē ʻana i nā lāʻau lapaʻau kuʻuna. ʻOiai ua hoʻomaikaʻi ka chemotherapy, nā hoʻoili cell stem, a me nā lāʻau lapaʻau hou i nā hopena, nui nā maʻi e kū nei i ke kūʻē ʻana i ka lāʻau. ʻO ka CAR-T (Chimeric Antigen Receptor T-cell) therapy kahi lāʻau lapaʻau groundbreaking i hōʻike i ka holomua kupaianaha i ka mālama ʻana i ka myeloma multiple relapsed a refractory, e hāʻawi ana i kahi hopena hoʻohiki no nā maʻi me nā koho palena.

ʻO ka lāʻau lapaʻau CAR-T e pili ana i ka hoʻololi ʻana i nā T-cell ponoʻī o ka mea maʻi e ʻike maikaʻi a hoʻouka i nā cell cancer. No ka myeloma multiple, ua hana ʻia nā CAR-T cell e kuhikuhi i ka BCMA (B-cell maturation antigen), kahi protein i loaʻa ma ka ʻili o nā cell myeloma. Ma hope o ka hoʻololi ʻia ʻana o ka genetics, ua hoʻokomo hou ʻia kēia mau T-cell i loko o ke kino o ka mea maʻi, kahi e ʻimi ai a luku i nā cell cancer, e alakaʻi ana i ke kala ʻana a me ke ola lōʻihi.

• Ka Pono Kiʻekiʻe ma ka Relapsed/Refractory MMUa hōʻike ʻia ka holomua nui o ka lāʻau lapaʻau CAR-T i nā poʻe maʻi me ka myeloma multiple relapsed a refractory paha, e loaʻa pinepine ana i ke kala piha ʻana a i ʻole ke kūlana maʻi koena liʻiliʻi (MRD).
• Pololei i Hoʻolālā ʻiaMa ka hoʻopaʻa ʻana iā BCMA, hoʻouka pololei ka lāʻau lapaʻau CAR-T i nā pūnaewele myeloma, e mālama ana i nā ʻiʻo olakino a hoʻemi ana i nā hopena ʻaoʻao i hoʻohālikelike ʻia me nā lāʻau lapaʻau maʻamau.
• Hoʻopilikino a me ka Hana HouHoʻohana ka lāʻau lapaʻau i nā T-cell ponoʻī o ka mea maʻi, e hōʻoiaʻiʻo ana i kahi hoʻolālā lapaʻau pilikino loa. Kōkua pū kēia i ka hōʻemi ʻana i ka pilikia o ka hōʻole ʻia.
• Hoʻokuʻu manawa lōʻihiHe nui nā maʻi i mālama ʻia me ka lāʻau lapaʻau CAR-T e ʻike i nā pane mau loa, me kekahi e mālama nei i ke kala ʻana no nā makahiki, ʻoiai ma hope o ka hāʻule ʻana o nā lāʻau lapaʻau ʻē aʻe.

• ʻOhiʻohi o nā pūnaewele TʻO ka hana mua e pili ana i ka hōʻiliʻili ʻana i nā pūnaewele T mai ke koko o ka mea maʻi me ka hoʻohana ʻana i ka leukapheresis, kahi hana like me ka hāʻawi koko.
• Ke hana ʻenekinia ʻana i nā pūnaewele TA laila hoʻouna ʻia kēia mau pūnaewele T i kahi keʻena hoʻokolohua, kahi i hoʻololi ʻia ai lākou i ka genetics e hōʻike i ka CAR kikoʻī i BCMA, e hoʻonui ana i ko lākou hiki ke ʻike a pepehi i nā pūnaewele myeloma.
• Hoʻokomo ʻia ʻana o nā pūnaewele CAR-TMa hope o ka hoʻonui ʻia ʻana i loko o ka lab, ua hoʻihoʻi ʻia nā T-cell i hana ʻia i loko o ke kahe koko o ka mea maʻi ma o kahi IV.
• Ka Nānā ʻana a me ka Hoʻōla ʻanaMa hope o ka hoʻokomo ʻana i ka infusion, nānā ʻia nā mea maʻi no nā hopena ʻaoʻao e like me ka cytokine release syndrome (CRS) a i ʻole neurotoxicity. ʻO ka maʻamau, hiki ke hoʻokele ʻia kēia mau hopena ʻaoʻao me ke komo ʻana o ka lāʻau lapaʻau a me ka nānā ʻana.

• ʻEnehana CAR-T Hou LoaHoʻohana ʻo BIOOCUS i nā holomua hou loa i ka ʻenehana CAR-T e hōʻoia i ka mālama ʻana i ke kūlana kiʻekiʻe loa a me nā hopena kūpono loa no nā poʻe maʻi MM.
• ʻIke Lapaʻau Papa HonuaHāʻawi kā mākou hui loea i ka hematology a me ka immunotherapy i ka mālama pilikino, e hōʻoiaʻiʻo ana e loaʻa ana i kēlā me kēia maʻi ka lāʻau maikaʻi loa no ko lākou kūlana kūikawā.
• Moʻolelo Kūlana i Hōʻoia ʻiaUa mālama mākou i nā maʻi MM he nui me ka lāʻau lapaʻau CAR-T, a ua nui ka poʻe i hoʻokō i nā kala ʻana kupaianaha a mau loa.
• Kākoʻo piha no nā maʻi o ka honuaHāʻawi ʻo BIOOCUS i ke kākoʻo piha no nā poʻe maʻi o ka honua, e alakaʻi ana iā ʻoe ma o kēlā me kēia ʻanuʻu o ke kaʻina hana lapaʻau, mai ke kūkākūkā mua ʻana a hiki i ka mālama ma hope o ka lapaʻau ʻana.

• Nā Hōʻike Lapaʻau a me nā Kūlana Holomua

  Ua hōʻike ka lāʻau lapaʻau CAR-T no ka myeloma lehulehu i nā hopena kupaianaha i nā hoʻokolohua lapaʻau a me nā hoʻonohonoho honua maoli. Ma ke ʻano kūikawā, ua hōʻoia ʻia he pono ia i nā poʻe maʻi i hoʻi hou ma hope o nā laina he nui o ka lāʻau lapaʻau, me kekahi e loaʻa ana i ke kala piha a i ʻole ke kūlana MRD-negative.

  • Ka Moʻolelo o ka Mea Maʻi: Ke Hoʻokō nei i ke Kala ʻana Lōʻihi me CAR-T no ka Myeloma Multiple
  • Haʻawina Hihia: Pane Piha Ma hope o ka Lapaʻau CAR-T ma ka Myeloma Multiple Relapsed
  • Ka Pono o ka CAR-T Therapy i ka mālama ʻana i ka Relapsed/Refractory Multiple Myeloma

  Hōʻike kēia mau haʻawina hihia pehea e hoʻololi nei ka lāʻau lapaʻau CAR-T i ke ʻano lapaʻau no ka myeloma maha, e hāʻawi ana i nā mea maʻi i ka manaʻolana no ke ola lōʻihi a me ka hoʻomaikaʻi ʻana i ke ʻano o ke ola.

Nā hōʻailona no CD19+20CAR-T:Nā maʻi me ka lymphoma B-cell non Hodgkin

Nā hōʻailona no CD19+22CAR-T:Ka mālama ʻana i nā maʻi leukemia B-lymphocytic acute i hoʻihoʻi ʻia mai ka CD19 a me ka refractory

Nā hōʻailona no BCMACAR-T:Ka mālama ʻana i ka myeloma maha relapsed a me ka refractory