Ngā Whakatairanga Hou i roto i ngā Pūtau Kaikōhuru Taiao (NK) Neke atu i te 50 Tau
Mai i ngā pūrongo tuatahi mō ngā lymphocytes e whakaatu ana i te patunga "kore-motuhake" o ngā pūtau pukupuku i te tau 1973, kua tino whanake te māramatanga me te hiranga o ngā pūtau Kaikōhuru Taiao (NK). I te tau 1975, i hangaia e Rolf Kiessling me ōna hoa mahi i te Karolinska Institute te kupu "pūtau Kaikōhuru Taiao", e whakaatu ana i tō rātou kaha ahurei ki te whakaeke i ngā pūtau pukupuku me te kore e pāngia i mua.
I roto i ngā tau rima tekau e whai ake nei, he maha ngā taiwhanga puta noa i te ao kua rangahau whānuitia Pūtau Nki roto i te vitro hei whakamārama i tā rātou mahi i roto i te tiaki i te tinana mai i ngā pukupuku me ngā huakita moroiti, tae atu ki ā rātou mahi whakahaere i roto i te pūnaha ārai mate.
Ngā Pūtau NK: Ngā Lymphocytes Taketake Paionia
Ko ngā pūtau NK, ngā mema tuatahi o te whānau lymphocyte ā-roto, ka tiaki i a rātou anō mai i ngā pukupuku me ngā mate pukupuku mā te mahi paitini tika me te whakaputanga o ngā cytokine me ngā chemokine. I te tīmatanga i huaina ko "ngā pūtau kore" nā te korenga o ngā tohu tautuhi, nā ngā whanaketanga o te raupapatanga RNA pūtau-kotahi, te cytometry rere, me te spectrometry papatipu kua taea ai te whakarōpū taipitopito o ngā momo pūtau NK.
Te Tekau Tau Tuatahi (1973-1982): Te Kitea o te Paitini Kore-Motuhake
I te mutunga o te tekau tau atu i 1960 me te tīmatanga o te tekau tau atu i 1970 i kitea te whanaketanga o ngā whakamātautau in vitro māmā hei ine i te paitini pūtau. I te tau 1974, i whakaatu a Herberman mā i ngā hoa mahi ka taea e ngā lymphocytes toto ā-taha mai i ngā tāngata hauora te patu i ngā pūtau lymphoma tangata. I whakaahua anō a Kiessling, Klein, me Wigzell i te pakaru ohorere o ngā pūtau pukupuku e ngā lymphocytes mai i ngā kiore kāore he pukupuku, me te tapa i tēnei mahi ko te "patu taiao."
Te Tekau Tau Tuarua (1983-1992): Te Āhuatanga Āhuatanga me te Parenga ki te Huaketo
I ngā tau 1980, ka neke te arotahi ki te whakaahuatanga o ngā pūtau NK, ā, ka kitea ngā momo pūtau me ngā mahi motuhake. Nō te tau 1983, kua kitea e ngā kaipūtaiao ngā momo pūtau NK tangata he rerekē te mahi. I roto i ētahi atu rangahau, i kitea te tūranga nui o ngā pūtau NK ki te tiaki i a rātou mai i ngā huaketo herpes, hei tauira, he tūroro e pangia ana e ngā mate herpes kino nā te ngoikore o ngā pūtau NK ira.
Te Tekau Tau Tuatoru (1993-2002): Te Mārama ki ngā Kaiwhakawhiwhi me ngā Rīki
Nā te ahunga whakamua nui i ngā tau 1990 me te tīmatanga o ngā tau 2000 i ārahi ki te tautuhi me te tārua i ngā kaiwhakawhiwhi pūtau NK me ō rātou hononga. Nā ngā kitenga pērā i te kaiwhakawhiwhi NKG2D me ōna hononga i puta mai i te ahotea i whakatū he turanga mō te mārama ki ngā tikanga mohio "kua whakarerekētia-ake" o ngā pūtau NK.
Te Tekau Tau Tuawhā (2003-2012): Te Mahara me te Raihana Pūtau NK
He rerekē ki ngā tirohanga tuku iho, i whakaatuhia e ngā rangahau i ngā tau 2000 ka taea e ngā pūtau NK te whakaatu i ngā urupare rite ki te mahara. I whakaatuhia e ngā kairangahau ka taea e ngā pūtau NK te whakahaere i ngā urupare motuhake ki te antigen me te whakawhanake i tētahi momo "mahara" e rite ana ki ngā pūtau ārai mate urutau. I tua atu, i puta te ariā o te "raihana" pūtau NK, e whakamārama ana me pēhea te whakarei ake i te urupare a ngā pūtau NK i ngā taunekeneke me ngā ngota MHC-whaiaro.
Te Tekau Tau Tuarima (2013-Nō Nāianei): Ngā Whakamahinga Hauora me te Kanorau
I roto i te tekau tau kua pahure ake nei, kua akiakihia e ngā whanaketanga hangarau te rangahau pūtau NK. Nā te cytometry papatipu me te raupapatanga RNA pūtau-kotahi i whakaatu te whānuitanga o te kanorau phenotypic i waenga i ngā pūtau NK. I roto i te haumanu, kua whakaatuhia e ngā pūtau NK he pūmanawa ki te rongoā i ngā mate pukupuku toto, e whakaatuhia ana e te tono angitu o ngā pūtau CD19 CAR-NK i roto i ngā tūroro lymphoma i te tau 2020.
Ngā Tirohanga o te Ao: Ngā Pātai Kāore anō kia Whakautua me ngā Paenga Hou
I te haere tonu o ngā rangahau, kei te toe tonu ētahi pātai whakamere. Me pēhea te whiwhi mahara motuhake a ngā pūtau NK ki ngā mate pūmua? Ka taea te whakamahi i ngā pūtau NK hei whakahaere i ngā mate pūnaha ārai mate? Me pēhea tātou e wikitoria ai i ngā wero e pā ana ki te taiao moroiti pukupuku hei whakahohe i ngā pūtau NK? Ko ngā tau rima tekau e whai ake nei e whakaari ana i ngā kitenga whakahihiri me te ohorere i roto i te koiora pūtau NK, e tuku ana i ngā rautaki rongoā hou mō te mate pukupuku me te Ngā Mate Pirau.