Tsoelo-pele ea Lisele tsa 'Molai oa Tlhaho (NK) Lilemo tse fetang 50
Ho tloha litlalehong tsa pele tsa li-lymphocyte tse bontšang polao ea "eseng e ikhethang" ea lisele tsa hlahala ka 1973, kutloisiso le bohlokoa ba lisele tsa Mobolai oa Tlhaho (NK) li fetohile haholo. Ka 1975, Rolf Kiessling le basebetsi-'moho le eena Setsing sa Karolinska ba ile ba qapa lentsoe "Lisele tsa Mobolai oa Tlhaho", ba totobatsa bokhoni ba bona bo ikhethang ba ho hlasela lisele tsa hlahala ka boithatelo ntle le ho lemoha pele.
Lilemong tse mashome a mahlano tse tlang, lilaboratori tse ngata lefatšeng ka bophara li ithutile ka botlalo Sele ea Nks in vitro ho hlakisa karolo ea tsona tšireletsong ea moamoheli khahlanong le lihlahala le likokoana-hloko tse bakang mafu, hammoho le mesebetsi ea tsona ea taolo ka har'a sistimi ea 'mele ea ho itšireletsa mafung.
Lisele tsa NK: Li-Lymphocyte tsa Tlhaho tse Qalang
Lisele tsa NK, e leng litho tsa pele tse khetholloang tsa lelapa la tlhaho la lymphocyte, li itšireletsa khahlanong le lihlahala le likokoana-hloko ka ts'ebetso e tobileng ea cytotoxic le ho ntšoa ha li-cytokine le li-chemokine. Qalong li ne li bitsoa "lisele tse se nang letho" ka lebaka la ho hloka matšoao a khethollang, tsoelo-pele ho tatellano ea RNA ea sele e le 'ngoe, cytometry ea phallo, le spectrometry ea bongata li lumelletse ho hlophisoa ka botlalo ha mefuta e fapaneng ea lisele tsa NK.
Lilemo tse Leshome tsa Pele (1973-1982): Ho Sibolla Chefo e sa Hlalosoang ea Cytotoxicity
Bofelong ba bo-1960 le mathoasong a bo-1970 ho ile ha bonoa nts'etsopele ea liteko tse bonolo tsa in vitro ho lekanya chefo ea lisele e bakoang ke lisele. Ka 1974, Herberman le basebetsi-'moho le eena ba bontšitse hore li-lymphocyte tsa mali tse tsoang ho batho ba phetseng hantle li ka bolaea lisele tse fapaneng tsa lymphoma tsa batho. Kiessling, Klein le Wigzell ba ile ba hlalosa ka ho eketsehileng ho phatloha ha lisele tsa hlahala ka li-lymphocyte tse tsoang ho litoeba tse se nang hlahala, ba re mosebetsi ona ke "polao ea tlhaho."
Lilemo tse Leshome tsa Bobeli (1983-1992): Tlhaloso ea Litšobotsi tsa Phenotypic le Tšireletso ea Kokwana-hloko
Nakong ea bo-1980, tlhokomelo e ile ea fetela ho tlhaloso ea phenotypic ea lisele tsa NK, e leng se ileng sa lebisa ho khetholloeng ha lihlopha tse nyenyane tse nang le mesebetsi e fapaneng. Ka 1983, bo-rasaense ba ne ba se ba hlwaile lihlopha tse fapaneng tsa lisele tsa NK tsa batho ka mokhoa o sebetsang. Lithuto tse ling li ile tsa totobatsa karolo ea bohlokoa ea lisele tsa NK ho sireletseng khahlanong le livaerase tsa herpes, e bontšitsoeng ke mokuli ea nang le tšoaetso e matla ea herpesvirus ka lebaka la khaello ea sele ea NK ea lefutso.
Lilemo tse Leshome tsa Boraro (1993-2002): Ho Utloisisa Li-Receptors le Ligands
Tsoelo-pele e kholo lilemong tsa bo-1990 le mathoasong a bo-2000 e lebisitse ho khetholloeng le ho kopanngoa ha li-receptor tsa sele ea NK le li-ligand tsa tsona. Lintho tse sibolotsoeng tse kang receptor ea NKG2D le ligand tsa eona tse bakoang ke khatello ea maikutlo li thehile motheo oa ho utloisisa mekhoa ea ho lemoha lisele tsa NK "tse fetotsoeng".
Lilemo tse Leshome tsa Bone (2003-2012): Memori le Laesense ea Sele ea NK
Ho fapana le maikutlo a setso, lithuto tsa lilemong tsa bo-2000 li bontšitse hore lisele tsa NK li ka bontša likarabo tse kang tsa memori. Bafuputsi ba bontšitse hore lisele tsa NK li ka buella likarabo tse ikhethileng tsa antigen le ho hlahisa mofuta oa "memori" o tšoanang le lisele tsa 'mele tse ikamahanyang le maemo. Ho phaella moo, khopolo ea "laesense" ea lisele tsa NK e ile ea hlaha, e hlalosa kamoo likamano le limolek'hule tsa MHC tse ikemetseng li ka ntlafatsang karabelo ea lisele tsa NK.
Lilemo tse Leshome tse Hlano (2013-Hona joale): Litšebeliso tsa Bongaka le Mefuta-futa
Lilemong tse leshome tse fetileng, tsoelo-pele ea theknoloji e tsamaisitse lipatlisiso tsa lisele tsa NK. Ho hlahlojoa ha lisele tsa NK ka bongata le ho latellana ha lisele tsa RNA ka sele e le 'ngoe ho senotse mefuta e mengata ea phenotypic har'a lisele tsa NK. Ka bongaka, lisele tsa NK li bontšitse tšepiso ea ho phekola mofetše oa mali, joalo ka ha ho bontšitsoe ke ts'ebeliso e atlehileng ea lisele tsa CD19 CAR-NK ho bakuli ba lymphoma ka 2020.
Litebello tsa Nakong e Tlang: Lipotso tse sa Arajoang le Lipakane tse Ncha
Ha dipatlisiso di ntse di tswela pele, ho ntse ho na le dipotso tse mmalwa tse thahasellisang. Disele tsa NK di fumana memori e ikgethang ya antigen jwang? Na disele tsa NK di ka sebediswa ho laola mafu a ikemelang mmeleng? Re ka hlola diphephetso tse bakwang ke tikoloho e nyane ya hlahala jwang ho kenya tshebetsong disele tsa NK ka katleho? Dilemo tse mashome a mahlano tse tlang di tshepisa diphihlello tse thabisang le tse sa lebellwang baelojing ya sele ya NK, tse fanang ka mawa a matjha a kalafo bakeng sa kankere le Mafu a tšoaetsanoang.