Kurapa Kwemasero eCAR-T Kunochinja Kurapa Kwezvirwere Zvikuru zveMaseru eB
Muongororo yakabudiswa munguva pfupi yapfuura muJournal of the National Cancer Center, nyanzvi dzeLu Daopei Hospital, dzichitungamirwa naDr. Peihua Lu, pamwe chete nevamwe vanobva kuYunivhesiti yeTexas MD Anderson Cancer Center, vakajekesa kufambira mberi kwazvino mukurapa masero eCAR-T pakurapa kenza yeB-cell. Ongororo iyi yakazara inokurukura nzira dzinoverengeka itsva, kusanganisira kushanduka kwekugadzirwa kwemasero eCAR-T uye kubatanidzwa kwemishonga yeadoptive cell, kuvandudza kushanda nekuchengetedzeka kwemishonga yezvirwere zvakaita senon-Hodgkin's lymphoma (NHL) uye acute lymphoblastic leukemia (ALL).
Maronda emasero eB anokonzeresa matambudziko makuru nekuda kwekuda kwawo kudzokera shure uye kuramba kurapwa nenzira dzechinyakare. Kuunzwa kwemasero eT-receptor echimeric antigen (CAR) kwakachinja mamiriro ekurapa, zvichipa tariro itsva kuvarwere vari kutarisana nekenza idzi dzine simba. Chidzidzo ichi chinosimbisa kuti masero eCAR T anogona kugadzirwa sei nezvizvarwa zvakasiyana-siyana zvekugadzira, zvichisanganisira zvinhu zvepamusoro zvakaita sema-receptor e-bispecific uye nzvimbo dzinosimudzira costimulatory, kuti zvinyatso tarisa masero egomarara uye kuderedza mukana wekudzokazve.
Chipatara cheLu Daopei chave chiri pamberi mukutsvaga nekushandisa masero eCAR-T, zvichiratidza kubudirira kukuru mukuita kuti masero agare kwenguva refu achibviswa. Kubatanidzwa kwechipatara mubasa iri rekutanga kunosimbisa kuzvipira kwacho mukusimudzira Kurapa Kenza uye kupa rubatsiro rwemazuva ano. Ongororo iyi inoongororawo mukana wekubatanidza mishonga yeCAR-T nedzimwe nzira dzekurapa, dzakadai sekurapa nekudzivirira muviri uye nzira dzekurapa dzakanangana, kuti kukunde nzira dzekudzivirira chirwere uye kuvandudza mhedzisiro yemurwere.
Bhuku iri rinoratidza kushanda pamwe chete kwevaongorori vepasi rose nevanachiremba mukusimudzira miganhu yekurapa kenza. Zvakawanikwa izvi zvinopa ruzivo rweramangwana rekenza chaiyo, uko mishonga yakagadzirwa nemunhu uye itsva inogona kushandura hupenyu hwevarwere vanorwara nekenza yeB cell. Mipiro yeLu Daopei Hospital mumunda uyu chiratidzo chetariro, ichitungamira kukura kwekurapa kenza kwakachengeteka uye kunoshanda.