Hoʻololi nā lāʻau lapaʻau CAR-T Cell hou i ka mālama ʻana i nā maʻi ʻino o B Cell

Ma kahi loiloi hou i paʻi ʻia ma ka Journal of the National Cancer Center, ua hoʻomālamalama nā loea mai ka Halemai ʻo Lu Daopei, i alakaʻi ʻia e Kauka Peihua Lu, me nā hoa hana mai ke Kulanui o Texas MD Anderson Cancer Center, i nā holomua hou loa i nā lāʻau lapaʻau CAR-T no ka mālama ʻana i nā maʻi ʻino B-cell. Kūkākūkā kēia loiloi piha i kekahi mau ʻano hana hou, me ka ulu ʻana o ka hoʻolālā cell CAR-T a me ka hoʻohui ʻana o nā lāʻau lapaʻau cell adoptive, e hoʻomaikaʻi i ka pono a me ka palekana o nā lāʻau lapaʻau no nā maʻi e like me ka non-Hodgkin's lymphoma (NHL) a me ka acute lymphoblastic leukemia (ALL).

ʻO nā maʻi ʻino o nā cell B ke kumu o nā pilikia koʻikoʻi ma muli o ko lākou ʻano e hoʻi hou a hoʻomohala i ke kūʻē i nā lāʻau lapaʻau maʻamau. ʻO ka hoʻolauna ʻana o nā cell chimeric antigen receptor (CAR) T ua hoʻololi i ke ʻano therapeutic, e hāʻawi ana i ka manaʻolana hou i nā poʻe maʻi e kū nei i kēia mau maʻi kanesa. Hōʻike ka haʻawina pehea e hiki ai ke hana ʻia nā cell CAR T me nā hanauna he nui o ka hoʻolālā, e hoʻokomo ana i nā hiʻohiʻona holomua e like me nā receptors bispecific a me nā kikowaena costimulatory, e kuhikuhi pono i nā cell tumor a hōʻemi i ka hiki ke hoʻi hou.

Ua noho ka Halemai ʻo Lu Daopei ma ke alo o ka noiʻi ʻana i nā cell CAR-T a me ka hoʻohana ʻana i nā lāʻau lapaʻau, e hōʻike ana i ka holomua kupaianaha i ka hoʻoulu ʻana i nā hoʻomaha lōʻihi. ʻO ke komo ʻana o ka haukapila i kēia hana paionia e hōʻike ana i kona kūpaʻa i ka hoʻolaha ʻana. Ka Lapaʻau ʻana i ka Maʻi ʻAʻai a me ka hāʻawi ʻana i ka mālama kiʻekiʻe loa. Ke nānā pū nei ka loiloi i ka hiki ke hoʻohui i nā lāʻau lapaʻau CAR-T me nā lāʻau lapaʻau ʻē aʻe, e like me ka immunotherapy a me nā lāʻau lapaʻau i kuhikuhi ʻia, e lanakila ai i nā ʻano kūʻē a hoʻomaikaʻi i nā hopena o ka mea maʻi.

He hōʻike kēia puke pai i nā hana hui pū ʻana o nā mea noiʻi honua a me nā kauka lapaʻau i ka hoʻokuke ʻana i nā palena o ka mālama ʻana i ka maʻi kanesa. Hāʻawi nā ʻike i kahi ʻike i ka wā e hiki mai ana o ka oncology pololei, kahi e hiki ai i nā lāʻau lapaʻau pilikino a me nā mea hou ke hoʻololi i ke ola o nā maʻi e hakakā nei i nā maʻi ʻino o nā cell B. ʻO nā hāʻawi a ka Halemai ʻo Lu Daopei i kēia kahua he kukui o ka manaʻolana, e hoʻokele ana i ka hoʻomohala ʻana o nā lāʻau lapaʻau kanesa palekana a ʻoi aku ka maikaʻi.