Unyango lweeCell zeCAR-T ezintsha luguqula unyango lweeB Cell Malignancies
Kuphononongo lwakutshanje olupapashwe kwiJournal of the National Cancer Center, iingcali ezivela kwiSibhedlele iLu Daopei, ezikhokelwa nguGqr. Peihua Lu, kunye nabasebenzisana nabo kwiYunivesithi yaseTexas MD Anderson Cancer Center, bakhanyisele inkqubela phambili yamva nje kunyango lweeseli zeCAR-T kunyango lwe-B-cell monoancies. Olu phononongo lubanzi luxoxa ngeendlela ezininzi ezintsha, kubandakanya ukuvela koyilo lweeseli zeCAR-T kunye nokuhlanganiswa konyango lweeseli ezamkelweyo, ukuphucula ukusebenza kakuhle kunye nokhuseleko lonyango lwezifo ezifana ne-non-Hodgkin's lymphoma (NHL) kunye ne-acute lymphoblastic leukemia (ALL).
Ii-B-cell malignancies zibangela imingeni emikhulu ngenxa yokuthambekela kwazo ekubuyeleni umva kwaye zivelise ukuxhathisa kunyango oluqhelekileyo. Ukwaziswa kwee-chimeric antigen receptor (CAR) T cells kutshintshe indlela yokunyanga, kunika ithemba elitsha kwizigulane ezijongene nale mihlaza inamandla. Olu phononongo lubonisa indlela ii-CAR T cells ezinokwakhiwa ngayo ngezizukulwana ezininzi zoyilo, kubandakanya iimpawu eziphambili ezifana nee-bispecific receptors kunye neendawo ze-costimulatory, ukuze zijolise ngakumbi kwiiseli ze-tumor kwaye zinciphise amathuba okubuyela umva.
Isibhedlele iLu Daopei besiphambili kuphando lweeseli zeCAR-T kunye nokusetyenziswa kwezonyango, sibonakalise impumelelo emangalisayo ekukhuthazeni ukukhululwa kwexesha elide. Ukubandakanyeka kwesibhedlele kulo msebenzi wokuqala kugxininisa ukuzinikela kwaso ekuphuculeni Unyango lomhlaza kunye nokubonelela ngononophelo olusemgangathweni. Olu phononongo lukwahlola amandla okudibanisa unyango lwe-CAR-T kunye nolunye unyango, olufana nonyango lwe-immunotherapy kunye nonyango olujolise kulo, ukoyisa iindlela zokuxhathisa kunye nokuphucula iziphumo zesigulana.
Olu shicilelo lubungqina bemizamo yokusebenzisana yabaphandi bamazwe ngamazwe kunye noogqirha ekutyhaleleni imida yonyango lomhlaza. Ezi ziphumo zibonelela ngekamva le-oncology echanekileyo, apho unyango olulungiselelwe wena kunye nolutsha lunokutshintsha ubomi bezigulane ezilwa nomhlaza we-B cell. Igalelo leSibhedlele iLu Daopei kweli candelo liyibhanile yethemba, liqhuba uphuhliso lonyango lomhlaza olukhuselekileyo nolusebenzayo ngakumbi.