Ukwelashwa Kwamaseli E-CAR-T Okusha Kuguqula Ukwelashwa Kwezifo Ezimbi Zamaseli E-B
Ekubuyekezweni kwakamuva okushicilelwe kuyi-Journal of the National Cancer Center, ochwepheshe baseLu Daopei Hospital, abaholwa nguDkt. Peihua Lu, kanye nabalingani abavela e-University of Texas MD Anderson Cancer Center, bakhanyise ngentuthuko yakamuva ekwelashweni kwamaseli e-CAR-T ekwelapheni umdlavuza wamaseli e-B. Lokhu kubuyekezwa okuphelele kuxoxa ngezindlela eziningana ezintsha, okuhlanganisa ukuvela komklamo wamaseli e-CAR-T kanye nokuhlanganiswa kwezindlela zokwelapha zamaseli ezithathwe, ukuthuthukisa ukusebenza kahle nokuphepha kokwelashwa kwezifo ezifana ne-non-Hodgkin's lymphoma (NHL) kanye ne-acute lymphoblastic leukemia (ALL).
Umdlavuza wamaseli e-B uletha izinselelo ezinkulu ngenxa yokuthambekela kwawo ekuphindeni futhi athuthukise ukumelana nemithi yokwelapha evamile. Ukwethulwa kwamaseli e-chimeric antigen receptor (CAR) T kushintshe indlela yokwelapha, kunikeza ithemba elisha ezigulini ezibhekene nalezi zimdlavuza ezinamandla. Ucwaningo luqokomisa indlela amaseli e-CAR T angaklanywa ngayo ngezizukulwane eziningi zomklamo, kufaka phakathi izici ezithuthukisiwe ezifana nama-receptor amabili kanye nezizinda ze-costimulatory, ukuze kuhloswe ngempumelelo amaseli esimila futhi kuncishiswe amathuba okubuyela emuva.
Isibhedlela iLu Daopei besilokhu sihamba phambili ocwaningweni lwamaseli e-CAR-T kanye nokusetshenziswa kwemitholampilo, sibonise impumelelo emangalisayo ekubangeleni ukuphulukiswa kwesikhathi eside. Ukubandakanyeka kwesibhedlela kulo msebenzi wobuphayona kugcizelela ukuzibophezela kwaso ekuthuthukiseni Ukwelashwa Komdlavuza kanye nokunikeza ukunakekelwa kwesimanje. Ukubuyekezwa kuphinde kuhlole amandla okuhlanganisa ukwelashwa kwe-CAR-T nezinye izindlela zokwelapha, njengokwelashwa nge-immunotherapy kanye nezindlela zokwelapha eziqondiwe, ukuze kunqotshwe izindlela zokumelana nokwelashwa futhi kuthuthukiswe imiphumela yeziguli.
Le ncwadi iwubufakazi bemizamo yokubambisana yabacwaningi bamazwe ngamazwe kanye nodokotela ekucindezeleni imingcele yokwelashwa komdlavuza. Okutholakele kunikeza umbono ngekusasa le-oncology enembile, lapho izindlela zokwelapha ezenzelwe wena kanye nezintsha zingaguqula khona izimpilo zeziguli ezilwa nomdlavuza we-B cell. Iminikelo yeSibhedlela iLu Daopei kulo mkhakha iyisibonakaliso sethemba, eqhuba ukuthuthukiswa kokwelashwa komdlavuza okuphephile nokuphumelelayo.