Mankhwala Atsopano a CAR-T Cell Amasintha Chithandizo cha Matenda a B Cell

Mu ndemanga yaposachedwa yomwe idasindikizidwa mu Journal of the National Cancer Center, akatswiri ochokera ku Lu Daopei Hospital, motsogozedwa ndi Dr. Peihua Lu, pamodzi ndi ogwira nawo ntchito ochokera ku The University of Texas MD Anderson Cancer Center, akuwonetsa kupita patsogolo kwaposachedwa kwa njira zochizira maselo a CAR-T pochiza khansa ya B-cell. Ndemanga yonseyi ikukambirana njira zingapo zatsopano, kuphatikizapo kusintha kwa kapangidwe ka maselo a CAR-T ndi kuphatikiza njira zochizira maselo olandirira, kuti akonze bwino komanso chitetezo cha mankhwala a matenda monga non-Hodgkin's lymphoma (NHL) ndi acute lymphoblastic leukemia (ALL).

Matenda a khansa a maselo a B amakhala ndi mavuto aakulu chifukwa chakuti amayamba kubwereranso m'thupi ndipo amakana mankhwala ochiritsira. Kuyambitsidwa kwa maselo a T a chimeric antigen receptor (CAR) kwasintha njira yochiritsira, kupereka chiyembekezo chatsopano kwa odwala omwe akukumana ndi khansa yoopsayi. Kafukufukuyu akuwonetsa momwe maselo a CAR T angapangidwire ndi mibadwo yambiri ya mapangidwe, kuphatikiza zinthu zapamwamba monga ma bispecific receptors ndi ma costimulatory domains, kuti athe kulunjika bwino maselo a khansa ndikuchepetsa mwayi wobwereranso m'thupi.

Chipatala cha Lu Daopei chakhala patsogolo pa kafukufuku wa maselo a CAR-T komanso kugwiritsa ntchito mankhwala, zomwe zawonetsa kupambana kwakukulu pakupangitsa kuti maselo azitha kuchira kwa nthawi yayitali. Kuchita nawo chipatalachi pantchito yoyambirirayi kukuwonetsa kudzipereka kwake pakupititsa patsogolo ntchito. Chithandizo cha Khansa ndi kupereka chisamaliro chapamwamba kwambiri. Ndemangayi ikufotokozanso kuthekera kophatikiza mankhwala a CAR-T ndi mankhwala ena, monga chithandizo cha chitetezo chamthupi ndi mankhwala ochizira omwe cholinga chake ndi kuthana ndi kukana matenda ndikukweza zotsatira za odwala.

Buku ili ndi umboni wa mgwirizano wa ofufuza ndi madokotala apadziko lonse lapansi popititsa patsogolo chithandizo cha khansa. Zomwe zapezekazi zikuwonetsa tsogolo la khansa yolondola, komwe njira zochiritsira zomwe munthu aliyense payekha komanso zatsopano zingasinthe miyoyo ya odwala omwe akulimbana ndi khansa ya maselo a B. Zopereka za Chipatala cha Lu Daopei ku gawoli ndi chiyembekezo, zomwe zikuyendetsa chitukuko cha njira zochiritsira khansa zotetezeka komanso zothandiza kwambiri.