Uburyo bushya bwo kuvura selile za CAR-T buhindura uburyo bwo kuvura kanseri y’uturemangingo twa B
Mu isuzuma riherutse gusohoka mu kinyamakuru Journal of the National Cancer Center, impuguke zo mu bitaro bya Lu Daopei, ziyobowe na Dr. Peihua Lu, hamwe n'abafatanyabikorwa bo muri Kaminuza ya Texas MD Anderson Cancer Center, bagaragaje iterambere rigezweho mu kuvura kanseri y'uturemangingo twa CAR-T. Iri suzuma rirambuye rivuga ku buryo bushya butandukanye, harimo iterambere ry'imiterere y'uturemangingo twa CAR-T no guhuza uburyo bwo kuvura uturemangingo twakira, kugira ngo kunoze imikorere n'umutekano w'ubuvuzi bw'indwara nka lymphoma itari iya Hodgkin (NHL) na leukemia y'urukozasoni ikabije (ALL).
Indwara za kanseri zo mu bwoko bwa B-cell zitera imbogamizi zikomeye bitewe n’uko zikunda kongera kurwara no kugira ubudahangarwa ku miti isanzwe. Ishyirwaho rya chimeric antigen receptor (CAR) T cells ryahinduye imiterere y’ubuvuzi, ritanga icyizere gishya ku barwayi bahura n’izi kanseri zikomeye. Ubu bushakashatsi bwerekana uburyo CAR T cells zishobora guhindurwa hifashishijwe imiterere y’ibisekuru byinshi, zigashyiramo ibintu bigezweho nka bispecific receptors na costimulatory domains, kugira ngo zirusheho kwibasira uturemangingo twa kanseri no kugabanya amahirwe yo kongera kurwara.
Ibitaro bya Lu Daopei byaje ku isonga mu bushakashatsi ku turemangingo twa CAR-T no mu mikoreshereze yabyo mu buvuzi, bigaragaza ko byagize icyo bigeraho mu gutuma habaho koroherwa kw'imiti mu gihe kirekire. Uruhare rw'ibitaro muri uyu murimo w'ibanze rugaragaza ubwitange bwabyo mu guteza imbere Ubuvuzi bwa kanseri no gutanga ubuvuzi bugezweho. Isuzuma kandi rigaragaza ubushobozi bwo guhuza uburyo bwo kuvura bwa CAR-T n'ubundi buryo bwo kuvura, nko kuvura ubudahangarwa bw'umubiri n'uburyo bwo kuvura bugamije, kugira ngo harengerwe uburyo bwo kurwanya indwara no kunoza umusaruro w'abarwayi.
Iki gitabo ni igihamya cy'ubufatanye bw'abashakashatsi mpuzamahanga n'abaganga mu kuzamura imbibi z'ubuvuzi bwa kanseri. Ibyavuye mu bushakashatsi bitanga ishusho y'ejo hazaza h'ubuvuzi bwa kanseri bugezweho, aho uburyo bwihariye kandi bugezweho bushobora guhindura ubuzima bw'abarwayi barwaye kanseri yo mu bwoko bwa B. Inkunga y'ibitaro bya Lu Daopei muri uru rwego ni urumuri rw'icyizere, rutera imbere mu kuvura kanseri mu buryo bwizewe kandi bunoze.