Txoj Kev Txhawb Nqa Tshiab Txhim Kho Kev Nyab Xeeb thiab Kev Ua Haujlwm Zoo ntawm CAR-T Kev Kho Mob hauv Acute B Cell Leukemia
Beijing, Suav teb - Lub Xya Hli 23, 2024 – Hauv kev txhim kho tshiab, Tsev Kho Mob Lu Daopei, koom tes nrog Hebei Senlang Biotechnology, tau tshaj tawm cov txiaj ntsig zoo los ntawm lawv txoj kev tshawb fawb tshiab tshaj plaws txog kev kho mob chimeric antigen receptor T (CAR-T) cell. Txoj kev tshawb fawb no, uas tsom mus rau qhov ua tau zoo thiab kev nyab xeeb ntawm CAR-T cells uas tau tsim los ntawm cov neeg txhawb nqa sib txawv, yog ib qho kev nce qib tseem ceeb hauv kev kho mob ntawm cov kab mob B cell leukemia uas rov qab los lossis tsis kho tau (B-ALL).
Daim ntawv tshawb fawb no, hu ua "Kev Siv Promoter Regulating the Surface Density of CAR Molecules May Modulate the Kinetics of CAR-T Cells In Vivo," tshawb nrhiav seb qhov kev xaiv ntawm promoter tuaj yeem cuam tshuam rau kev ua haujlwm ntawm CAR-T cell li cas. Cov kws tshawb fawb Jin-Yuan Ho, Lin Wang, Ying Liu, Min Ba, Junfang Yang, Xian Zhang, Dandan Chen, Peihua Lu, thiab Jianqiang Li los ntawm Hebei Senlang Biotechnology thiab Lu Daopei Hospital tau ua tus thawj coj hauv kev tshawb fawb no.
Lawv cov kev tshawb pom qhia tau hais tias kev siv MND (myeloproliferative sarcoma virus MPSV enhancer, negative control region NCR deletion, d1587rev primer binding site replacement) promoter hauv CAR-T cell ua rau qhov ntom ntawm CAR molecules qis dua, uas ua rau txo cov cytokine ntau lawm. Qhov no tseem ceeb vim nws pab txo cov kev mob tshwm sim loj uas feem ntau cuam tshuam nrog CAR-T therapy, xws li cytokine release syndrome (CRS) thiab CAR-T cell-related encephalopathy syndrome (CRES).
Qhov kev sim tshuaj kho mob, sau npe rau hauv ClinicalTrials.gov tus cim NCT03840317, suav nrog 14 tus neeg mob faib ua ob pawg: ib tus tau txais MND-driven CAR-T hlwb thiab lwm tus tau txais EF1A promoter-driven CAR-T hlwb. Qhov zoo kawg nkaus, txhua tus neeg mob uas tau kho nrog MND-driven CAR-T hlwb tau ua tiav kev zam txim tag nrho, nrog rau feem ntau ntawm lawv qhia txog qhov tsis zoo ntawm tus kab mob tom qab lub hlis thawj zaug. Kev tshawb fawb kuj tau tshaj tawm tias muaj qhov tshwm sim tsawg dua ntawm CRS thiab CRES hnyav hauv cov neeg mob uas tau kho nrog MND-driven CAR-T hlwb piv rau cov neeg uas tau kho nrog EF1A-driven hlwb.
Dr. Peihua Lu ntawm Lu Daopei Tsev Kho Mob tau hais tias nws zoo siab txog qhov muaj peev xwm ntawm txoj hauv kev tshiab no, hais tias, "Peb txoj kev koom tes nrog Hebei Senlang Biotechnology tau muab cov kev nkag siab tseem ceeb rau kev kho CAR-T cell. Los ntawm kev kho tus neeg txhawb nqa, peb tuaj yeem txhim kho qhov kev nyab xeeb ntawm kev kho mob thaum tseem tswj hwm nws cov txiaj ntsig. Qhov no yog ib kauj ruam tseem ceeb rau pem hauv ntej hauv kev ua kom CAR-T kev kho mob yooj yim dua thiab yooj yim rau cov neeg mob."
Txoj kev tshawb fawb no tau txais kev txhawb nqa los ntawm cov nyiaj pab los ntawm Natural Science Foundation ntawm Hebei Province thiab Department of Science and Technology ntawm Hebei Province. Nws qhia txog qhov tseem ceeb ntawm kev xaiv tus txhawb nqa hauv kev tsim cov tshuaj CAR-T cell thiab qhib txoj hauv kev tshiab rau kev nyab xeeb dua thiab ua haujlwm tau zoo dua. Kev Kho Mob Cancers.