He Rautaki Whakatairanga Hou e Whakapai Ake Ana i te Haumaru me te Whai Huatanga o te Whakaora CAR-T i roto i te Leukemia Pūtau B Whakapeka
Pēkini, Haina – 23 o Hūrae, 2024 – I roto i tētahi whanaketanga hou, kua huraina e te Hōhipera o Lu Daopei, i te mahi tahi me Hebei Senlang Biotechnology, ngā hua whakamīharo mai i tā rātou rangahau hou mō te whakaora pūtau chimeric antigen receptor T (CAR-T). Ko tēnei rangahau, e arotahi ana ki te whai huatanga me te haumaru o ngā pūtau CAR-T i hangaia ki ngā kaiwhakatairanga rerekē, he tohu i tētahi ahunga whakamua nui i roto i te maimoatanga o te relapse pūtau B acute leukemia (B-ALL) kua hoki mai, kua kore rānei e taea te whakatika.
Ko te taitara o te rangahau, "Promoter Usage Regulating the Surface Density of CAR Molecules May Modulate the Kinetics of CAR-T Cells In Vivo," e tūhura ana i te āhua o te awe o te kōwhiringa o te kaiwhakatairanga ki te mahi a ngā pūtau CAR-T. Ko ngā kairangahau a Jin-Yuan Ho, Lin Wang, Ying Liu, Min Ba, Junfang Yang, Xian Zhang, Dandan Chen, Peihua Lu, me Jianqiang Li o Hebei Senlang Biotechnology me Lu Daopei Hospital i ārahi i tēnei rangahau.
E whakaatu ana ā rātou kitenga ko te whakamahi i te MND (myeloproliferative sarcoma virus MPSV enhancer, negative control region NCR deletion, d1587rev primer binding site replacement) promoter i roto i ngā pūtau CAR-T ka arahi ki te iti o te mata o ngā ngota CAR, ka whakaiti i te hanga cytokine. He mea nui tēnei nā te mea ka āwhina ki te whakaiti i ngā pānga kino e pā ana ki te rongoā CAR-T, pērā i te cytokine release syndrome (CRS) me te CAR-T cell-related encephalopathy syndrome (CRES).
Ko te whakamātautau haumanu, i rēhitatia i raro i te tohu ClinicalTrials.gov NCT03840317, i whakaurua ki roto i ngā tūroro 14 i wehea kia rua ngā rōpū: tētahi e whiwhi ana i ngā pūtau CAR-T e peia ana e te MND, ko tētahi e whiwhi ana i ngā pūtau CAR-T e peia ana e te kaiwhakatairanga EF1A. He mea whakamiharo, ko ngā tūroro katoa i rongoatia ki ngā pūtau CAR-T e peia ana e te MND i tutuki te whakaoranga katoa, ā, ko te nuinga o rātou i whakaatu i te iti rawa o te āhua mate-kore i muri i te marama tuatahi. I kōrerohia hoki e te rangahau he iti ake te auau o te CRS me te CRES kino i roto i ngā tūroro i rongoatia ki ngā pūtau CAR-T e peia ana e te MND ki te whakataurite ki ērā i rongoatia ki ngā pūtau e peia ana e te EF1A.
I whakapuaki a Tākuta Peihua Lu o te Hōhipera o Lu Daopei i te tumanako mō te kaha o tēnei huarahi hou, me te kī, "Nā tā mātou mahi tahi me Hebei Senlang Biotechnology i hua mai he māramatanga nui ki te whakapai ake i te whakaora pūtau CAR-T. Mā te whakarerekē i te kaiwhakatairanga, ka taea e mātou te whakarei ake i te kōtaha haumaru o te maimoatanga me te pupuri tonu i tōna whai huatanga. He taahiraa nui tēnei ki mua i te mea kia māmā ake te uru atu me te manawanui o te whakaora CAR-T mō ngā tūroro."
I tautokona te rangahau e ngā putea tautoko mai i te Natural Science Foundation o te Porowini o Hebei me te Tari Pūtaiao me te Hangarau o te Porowini o Hebei. E whakaatu ana i te hiranga o te whiriwhiri i ngā kaiwhakatairanga i roto i te whanaketanga o ngā maimoatanga pūtau CAR-T, ā, e whakatuwhera ana i ngā huarahi hou mō ngā huarahi haumaru ake, whai hua ake hoki. Te Maimoatanga Matepukupukungā