Ingamba Nshya zo Guteza Imbere Umutekano n'Ingufu z'Ubuvuzi bwa CAR-T mu Kuvura Leukemia y'Uturemangingo tw'Umubiri (B cells)
Beijing, Ubushinwa – 23 Nyakanga 2024 – Mu iterambere rikomeye, Ibitaro bya Lu Daopei, ku bufatanye na Hebei Senlang Biotechnology, byashyize ahagaragara ibisubizo bishimishije bivuye mu bushakashatsi bwabyo buheruka ku buvuzi bwa chimeric antigen receptor T (CAR-T). Ubu bushakashatsi, bwibanda ku mikorere n'umutekano w'uturemangingo twa CAR-T twakozwe hifashishijwe imiti itandukanye, bugaragaza iterambere rikomeye mu kuvura kanseri y'amaraso ya B-ALL (B-ALL) isubira inyuma cyangwa idashobora kugaragara.
Ubushakashatsi, bwiswe "Ikoreshwa rya Promoter Rigenzura Ubucucike bw'Ubwinshi bw'Amaseli ya CAR Bishobora Guhindura Kinetiki y'Uturemangingo twa CAR-T muri Vivo," busesengura uburyo guhitamo promoter bishobora kugira ingaruka ku mikorere y'uturemangingo twa CAR-T. Abashakashatsi Jin-Yuan Ho, Lin Wang, Ying Liu, Min Ba, Junfang Yang, Xian Zhang, Dandan Chen, Peihua Lu, na Jianqiang Li bo muri Hebei Senlang Biotechnology na Lu Daopei Hospital bayoboye ubu bushakashatsi.
Ibyo babonye bigaragaza ko gukoresha MND (myeloproliferative sarcoma virus MPSV enhancer, negative control region NCR deletion, d1587rev primer binding site replacement) promoter mu turemangingo twa CAR-T bituma ubucucike bw'uturemangingo twa CAR bugabanuka, ibyo bigatuma umusaruro wa cytokine ugabanuka. Ibi ni ingenzi kuko bifasha kugabanya ingaruka mbi zikunze kugaragara mu buvuzi bwa CAR-T, nka cytokine release syndrome (CRS) na CAR-T cell-related encephalopathy syndrome (CRES).
Igerageza rya muganga, ryanditswe hakurikijwe indangamuntu ya ClinicalTrials.gov NCT03840317, ryari rigizwe n’abarwayi 14 bagabanyijemo amatsinda abiri: rimwe ryakira uturemangingo twa CAR-T dutwarwa na MND n’irindi ryakira uturemangingo twa CAR-T dutwarwa na EF1A. Igitangaje ni uko abarwayi bose bavuwe uturemangingo twa CAR-T dutwarwa na MND bakize burundu, abenshi muri bo bagaragaza ko badafite indwara nyuma y’ukwezi kwa mbere. Ubushakashatsi bwagaragaje kandi ko umubare muto w’abarwayi ba CRS na CRES barwaye ugereranyije n’abavuwe uturemangingo twa CAR-T dutwarwa na MND.
Dr. Peihua Lu wo mu bitaro bya Lu Daopei yagaragaje icyizere ku bushobozi bw'ubu buryo bushya, agira ati: "Ubufatanye bwacu na Hebei Senlang Biotechnology bwatanze ibitekerezo by'ingenzi mu kunoza uburyo bwo kuvura CAR-T cells. Dukoresheje uburyo bwo guhindura uburyo bwo kuvura, dushobora kongera umutekano w'ubuvuzi mu gihe tugakomeza kugira akamaro. Iyi ni intambwe ikomeye mu gutuma CAR-T therapy irushaho kuboneka no kwihanganirwa ku barwayi."
Ubu bushakashatsi bwatewe inkunga n'inkunga yatanzwe n'Ikigo cy'Ubumenyi Kamere cyo mu Ntara ya Hebei n'Ishami ry'Ubumenyi n'Ikoranabuhanga ryo mu Ntara ya Hebei. Bugaragaza akamaro ko guhitamo abaterankunga mu iterambere ry'ubuvuzi bwa selile za CAR-T kandi bugafungura inzira nshya zo kwirinda no gukora neza kurushaho. Ubuvuzi bwa kanseris.