Atụmatụ Mgbasa Ozi Ọhụrụ Na-eme Ka Nchekwa na Ịrụ Ọrụ nke Ọgwụgwọ CAR-T Ka Mma n'Ọrịa Ọrịa Leukemia Mkpụrụ Ndụ B Dị Oke Ọkụ

Beijing, Chaịna – Julaị 23, 2024 – N'ime mmepe ọhụrụ, Ụlọ Ọgwụ Lu Daopei, na mmekorita ya na Hebei Senlang Biotechnology, ekpughela nsonaazụ dị mma site na nnyocha ọhụrụ ha gbasara ọgwụgwọ mkpụrụ ndụ chimeric antigen receptor T (CAR-T). Ọmụmụ ihe a, nke lekwasịrị anya na arụmọrụ na nchekwa nke mkpụrụ ndụ CAR-T nke ejiri ndị na-akwalite ya dị iche iche mepụta, na-egosi ọganihu dị ukwuu n'ọgwụgwọ nke ọrịa leukemia mkpụrụ ndụ B nke na-alaghachi azụ ma ọ bụ nke na-adịghị agbanwe agbanwe (B-ALL).

Ọmụmụ ihe a, nke akpọrọ "Ojiji Onye Nkwalite Na-achịkwa Njupụta Elu nke Mkpụrụ ndụ CAR Nwere Ike Ịgbanwe Kinetics nke Mkpụrụ ndụ CAR-T Na Vivo," na-enyocha otu nhọrọ nke onye na-akwalite nwere ike isi metụta arụmọrụ nke mkpụrụ ndụ CAR-T. Ndị nchọpụta Jin-Yuan Ho, Lin Wang, Ying Liu, Min Ba, Junfang Yang, Xian Zhang, Dandan Chen, Peihua Lu, na Jianqiang Li sitere na Hebei Senlang Biotechnology na Lu Daopei Hospital duziri nnyocha a.

Nchọpụta ha gosiri na iji MND (myeloproliferative sarcoma virus MPSV enhancer, negative control region NCR deletion, d1587rev primer binding site replacement) promoter na mkpụrụ ndụ CAR-T na-eduga na obere njupụta elu nke mkpụrụ ndụ CAR, nke na-ebelata mmepụta cytokine. Nke a dị mkpa n'ihi na ọ na-enyere aka ibelata mmetụta ọjọọ dị njọ nke a na-ejikarị agwọ ọrịa CAR-T, dị ka cytokine release syndrome (CRS) na CAR-T cell-related encephalopathy syndrome (CRES).

Nnwale ahụike ahụ, nke edenyere aha ya n'okpuru njirimara ClinicalTrials.gov NCT03840317, gụnyere ndị ọrịa 14 kewara n'ime otu abụọ: otu na-enweta mkpụrụ ndụ CAR-T nke MND na-eduzi na nke ọzọ na-enweta mkpụrụ ndụ CAR-T nke EF1A na-eduzi. Ihe dị ịtụnanya bụ na ndị ọrịa niile ejiri mkpụrụ ndụ CAR-T nke MND na-eduzi gwọọ nwetara mgbaghara zuru oke, ebe ọtụtụ n'ime ha gosipụtara obere ọnọdụ ọrịa fọdụrụ mgbe ọnwa mbụ gasịrị. Ọmụmụ ihe ahụ kọkwara obere ọnụọgụ nke CRS na CRES dị njọ na ndị ọrịa ejiri mkpụrụ ndụ CAR-T nke MND na-eduzi gwọọ ma e jiri ya tụnyere ndị ejiri mkpụrụ ndụ EF1A na-eduzi gwọọ.

Dọkịta Peihua Lu si n'ụlọ ọgwụ Lu Daopei kwupụtara olileanya gbasara ike nke usoro ọhụrụ a, na-ekwu, "Mmekọrịta anyị na Hebei Senlang Biotechnology enyela nghọta dị mkpa n'ime ka ọgwụgwọ CAR-T dịkwuo mma. Site n'ịgbanwe onye na-akwalite ya, anyị nwere ike ime ka nchekwa nke ọgwụgwọ ahụ ka mma ma nọgide na-arụ ọrụ ya. Nke a bụ nzọụkwụ dị mkpa n'ime ka ọgwụgwọ CAR-T dịkwuo mfe ma dịrị ndị ọrịa mfe ịnagide."

E nyere onyinye sitere n'aka Natural Science Foundation nke Hebei Province na Ngalaba Sayensị na Teknụzụ nke Hebei Province kwadoro ọmụmụ ihe a. Ọ na-egosi mkpa ọ dị ịhọrọ ndị na-akwalite ya n'ịmepụta ọgwụgwọ mkpụrụ ndụ CAR-T ma na-emepe ụzọ ọhụrụ maka nchekwa na irè karịa. Ọgwụgwọ Ọrịa Kansas.