Nzira Itsva Yekukurudzira Inosimudzira Kuchengetedzeka uye Kushanda Kwekurapa kweCAR-T MuAcute B Cell Leukemia
Beijing, China – Chikunguru 23, 2024 – Mukufambira mberi kukuru, Chipatara cheLu Daopei, pamwe chete neHebei Senlang Biotechnology, chakaburitsa mhedzisiro inovimbisa kubva muongororo yavo yazvino pamusoro pekurapa kwemasero echimeric antigen receptor T (CAR-T). Chidzidzo ichi, chinotarisa pakushanda uye kuchengetedzeka kwemasero eCAR-T akagadzirwa nevanosimudzira vakasiyana, chinoratidza kufambira mberi kukuru mukurapa relapse or refractory acute B cell leukemia (B-ALL).
Chidzidzo ichi, chine musoro unoti "Kushandiswa kwePromoter Kudzora Kuwanda KwemaCAR Molecules Kunogona Kuchinja Kinetics yeCAR-T Cells In Vivo," chinoongorora kuti kusarudzwa kwepromoter kunogona sei kukanganisa mashandiro eCAR-T cells. Vaongorori Jin-Yuan Ho, Lin Wang, Ying Liu, Min Ba, Junfang Yang, Xian Zhang, Dandan Chen, Peihua Lu, naJianqiang Li vanobva kuHebei Senlang Biotechnology neLu Daopei Hospital vakatungamira tsvakiridzo iyi.
Zvakawanikwa zvinoratidza kuti kushandisa MND (myeloproliferative sarcoma virus MPSV enhancer, negative control region NCR deletion, d1587rev primer binding site replacement) promoter muCAR-T cells kunotungamira kudzikira kwehuwandu hweCAR molecules, izvo zvinoderedza kugadzirwa kwecytokine. Izvi zvakakosha nekuti zvinobatsira kuderedza migumisiro yakaipa inowanzobatanidzwa neCAR-T therapy, yakadai se cytokine release syndrome (CRS) uye CAR-T cell-related encephalopathy syndrome (CRES).
Kuedzwa kwekiriniki, kwakanyoreswa pasi peClinicalTrials.gov identifier NCT03840317, kwaisanganisira varwere gumi nevana vakakamurwa kuita mapoka maviri: rimwe raigamuchira masero eCAR-T anotungamirwa neMND uye rimwe raigamuchira masero eCAR-T anotungamirwa neEF1A. Zvinoshamisa kuti varwere vese vakarapwa nemasero eCAR-T anotungamirwa neMND vakawana zororo rakazara, vazhinji vavo vachiratidza kusavapo kwechirwere mushure memwedzi wekutanga. Chidzidzo ichi chakaratidzawo kuderera kwehuwandu hweCRS neCRES dzakakomba muvarwere vakarapwa nemasero eCAR-T anotungamirwa neMND zvichienzaniswa neavo vakarapwa nemasero anotungamirwa neEF1A.
Dr. Peihua Lu vekuLu Daopei Hospital vakaratidza tariro pamusoro pekugona kwenzira iyi itsva, vachiti, "Kushanda pamwe chete neHebei Senlang Biotechnology kwatipa ruzivo rwakakosha mukuvandudza CAR-T cell therapy. Nekugadzirisa promoter, tinogona kuvandudza kuchengetedzeka kwekurapa uku tichiramba tichishanda zvakanaka. Iri idanho rakakosha mukuita kuti CAR-T therapy ive nyore uye ishande zvakanaka kune varwere."
Chidzidzo ichi chakatsigirwa nemari kubva kuNatural Science Foundation yeHebei Province neDhipatimendi reSainzi neTekinoroji reHebei Province. Chinosimbisa kukosha kwekusarudza vanokurudzira mukuvandudza kurapwa kwemasero eCAR-T uye chinovhura nzira itsva dzekuchengetedza uye kushanda zvakanaka. Kurapa Kenzas.