Hoʻonui ka hoʻolālā hoʻolaha hou i ka palekana a me ka pono o ka CAR-T Therapy i ka Acute B Cell Leukemia
Beijing, Kina – Iulai 23, 2024 – Ma kahi hoʻomohala hou, ua hōʻike ka Halemai ʻo Lu Daopei, me ka laulima ʻana me Hebei Senlang Biotechnology, i nā hopena hoʻohiki mai kā lākou noiʻi hou loa ma ka chimeric antigen receptor T (CAR-T) cell therapy. ʻO kēia noiʻi, e kālele ana i ka pono a me ka palekana o nā cell CAR-T i hana ʻia me nā mea hoʻolaha like ʻole, e hōʻailona ana i kahi holomua koʻikoʻi i ka mālama ʻana i ka relapsed a refractory acute B cell leukemia (B-ALL).
ʻO ke aʻo ʻana, i kapa ʻia ʻo "Promoter Usage Regulating the Surface Density of CAR Molecules May Modulate the Kinetics of CAR-T Cells In Vivo," e ʻimi ana pehea e hiki ai i ke koho ʻana o ka mea hoʻolaha ke hoʻohuli i ka hana o nā cell CAR-T. Ua alakaʻi ʻia kēia noiʻi e nā mea noiʻi ʻo Jin-Yuan Ho, Lin Wang, Ying Liu, Min Ba, Junfang Yang, Xian Zhang, Dandan Chen, Peihua Lu, a me Jianqiang Li mai Hebei Senlang Biotechnology a me Lu Daopei Hospital.
Hōʻike kā lākou mau ʻike i ka hoʻohana ʻana i ka MND (myeloproliferative sarcoma virus MPSV enhancer, negative control region NCR deletion, d1587rev primer binding site replacement) promoter i loko o nā cell CAR-T e alakaʻi i ka haʻahaʻa o ka ʻili o nā molekala CAR, kahi e hōʻemi ai i ka hana cytokine. He mea nui kēia no ka mea kōkua ia i ka hoʻēmi ʻana i nā hopena ʻino e pili pinepine ʻia me ka lāʻau CAR-T, e like me ka cytokine release syndrome (CRS) a me ka CAR-T cell-related encephalopathy syndrome (CRES).
ʻO ka hoʻokolohua lapaʻau, i hoʻopaʻa inoa ʻia ma lalo o ka mea hōʻike ʻo ClinicalTrials.gov ʻo NCT03840317, ua hoʻokomo pū ʻia he 14 mau maʻi i māhele ʻia i ʻelua mau cohorts: hoʻokahi e loaʻa ana i nā pūnaewele CAR-T i hoʻokele ʻia e MND a ʻo kekahi e loaʻa ana i nā pūnaewele CAR-T i hoʻokele ʻia e ka mea hoʻolaha EF1A. ʻO ka mea kupanaha, ua loaʻa i nā maʻi āpau i mālama ʻia me nā pūnaewele CAR-T i hoʻokele ʻia e MND ke kala piha ʻana, me ka hapa nui o lākou e hōʻike ana i ke kūlana maʻi-maikaʻi ʻole ma hope o ka mahina mua. Ua hōʻike pū ka haʻawina i kahi emi o ka nui o CRS koʻikoʻi a me CRES i nā maʻi i mālama ʻia me nā pūnaewele CAR-T i hoʻokele ʻia e MND i hoʻohālikelike ʻia me nā mea i mālama ʻia me nā pūnaewele EF1A.
Ua hōʻike ʻo Kauka Peihua Lu mai ka Halemai ʻo Lu Daopei i ka manaʻolana e pili ana i ka hiki ke loaʻa i kēia ʻano hana hou, me ka ʻōlelo ʻana, "Ua loaʻa i kā mākou hui pū ʻana me Hebei Senlang Biotechnology nā ʻike koʻikoʻi i ka hoʻonui ʻana i ka lāʻau lapaʻau CAR-T cell. Ma ka hoʻoponopono ʻana i ka mea hoʻolaha, hiki iā mākou ke hoʻonui i ka palekana o ka lāʻau lapaʻau me ka mālama ʻana i kona pono. He ʻanuʻu koʻikoʻi kēia i mua i ka hoʻolilo ʻana i ka lāʻau lapaʻau CAR-T i mea maʻalahi a hiki ke ʻae ʻia no nā maʻi."
Ua kākoʻo ʻia ke aʻo ʻana e nā makana mai ka Natural Science Foundation o Hebei Province a me ke Keʻena ʻEpekema a me ka ʻenehana o Hebei Province. Hōʻike ia i ke koʻikoʻi o ke koho ʻana i ka mea hoʻolaha i ka hoʻomohala ʻana i nā lāʻau lapaʻau CAR-T cell a wehe i nā ala hou no ka palekana a me ka ʻoi aku ka maikaʻi. Ka Lapaʻau ʻana i ka Maʻi ʻAʻainā