Njira Yotsatsira Novel Imawonjezera Chitetezo ndi Kugwira Ntchito kwa Chithandizo cha CAR-T mu Khansa ya M'magazi ya Acute B Cell
Beijing, China – Julayi 23, 2024 – Pachitukuko chatsopano, Chipatala cha Lu Daopei, mogwirizana ndi Hebei Senlang Biotechnology, chavumbulutsa zotsatira zabwino kuchokera ku kafukufuku wawo waposachedwa pa chithandizo cha maselo a chimeric antigen receptor T (CAR-T). Kafukufukuyu, womwe umayang'ana kwambiri pakugwira ntchito bwino komanso chitetezo cha maselo a CAR-T opangidwa ndi othandizira osiyanasiyana, akuwonetsa kupita patsogolo kwakukulu pakuchiza khansa ya m'magazi ya B-ALL yomwe yabwereranso kapena yokana.
Kafukufukuyu, wotchedwa "Kugwiritsa Ntchito Promoter Regulating the Surface Density of CAR Molecules May Modulate the Kinetics of CAR-T Cells In Vivo," akufufuza momwe kusankha promoter kungakhudzire magwiridwe antchito a maselo a CAR-T. Ofufuza Jin-Yuan Ho, Lin Wang, Ying Liu, Min Ba, Junfang Yang, Xian Zhang, Dandan Chen, Peihua Lu, ndi Jianqiang Li ochokera ku Hebei Senlang Biotechnology ndi Lu Daopei Hospital adatsogolera kafukufukuyu.
Zomwe apeza zikusonyeza kuti kugwiritsa ntchito MND (myeloproliferative sarcoma virus MPSV enhancer, negative control region NCR deletion, d1587rev primer binding site replacement) promoter mu maselo a CAR-T kumabweretsa kuchepa kwa mamolekyulu a CAR pamwamba, zomwe zimachepetsa kupanga kwa cytokine. Izi ndizofunikira chifukwa zimathandiza kuchepetsa zotsatira zoyipa zomwe nthawi zambiri zimagwirizanitsidwa ndi chithandizo cha CAR-T, monga cytokine release syndrome (CRS) ndi CAR-T cell-related encephalopathy syndrome (CRES).
Kuyesa kwachipatala, komwe kunalembedwa pansi pa chizindikiro cha ClinicalTrials.gov NCT03840317, kunaphatikizapo odwala 14 omwe anagawidwa m'magulu awiri: limodzi lolandira maselo a CAR-T oyendetsedwa ndi MND ndi lina lolandira maselo a CAR-T oyendetsedwa ndi EF1A. Chodabwitsa n'chakuti, odwala onse omwe adalandira maselo a CAR-T oyendetsedwa ndi MND adachira kwathunthu, ndipo ambiri mwa iwo adawonetsa kuti alibe matenda pambuyo pa mwezi woyamba. Kafukufukuyu adanenanso kuti kuchuluka kwa CRS ndi CRES koopsa mwa odwala omwe adalandira maselo a CAR-T oyendetsedwa ndi MND poyerekeza ndi omwe adalandira maselo oyendetsedwa ndi EF1A.
Dokotala Peihua Lu wochokera ku Lu Daopei Hospital adawonetsa chidaliro chake pa kuthekera kwa njira yatsopanoyi, ponena kuti, "Kugwirizana kwathu ndi Hebei Senlang Biotechnology kwapereka chidziwitso chofunikira kwambiri pakukonza chithandizo cha maselo a CAR-T. Mwa kusintha chothandizira, titha kukulitsa chitetezo cha chithandizocho pamene tikupitirizabe kugwira ntchito bwino. Iyi ndi sitepe yofunika kwambiri popangitsa kuti chithandizo cha CAR-T chikhale chosavuta kupeza komanso chovomerezeka kwa odwala."
Kafukufukuyu adathandizidwa ndi ndalama zothandizira kuchokera ku Natural Science Foundation of Hebei Province ndi Dipatimenti ya Sayansi ndi Ukadaulo ya Hebei Province. Ikuwonetsa kufunika kosankha othandizira pakupanga njira zochiritsira maselo a CAR-T ndikutsegula njira zatsopano zotetezeka komanso zogwira mtima. Chithandizo cha Khansas.