Novel Promoter Strategy Imakulitsa Chitetezo ndi Kuchita Bwino kwa CAR-T Therapy mu Acute B Cell Leukemia

Beijing, China - Julayi 23, 2024- Pachitukuko chodabwitsa, Chipatala cha Lu Daopei, mogwirizana ndi Hebei Senlang Biotechnology, chavumbulutsa zotsatira zodalirika kuchokera ku kafukufuku wawo waposachedwa pa chimeric antigen receptor T (CAR-T) cell therapy. Kafukufukuyu, yemwe amayang'ana kwambiri mphamvu ndi chitetezo cha maselo a CAR-T opangidwa ndi olimbikitsa osiyanasiyana, akuwonetsa kupita patsogolo kwakukulu pakuchiza matenda obwereranso kapena kukana acute B cell leukemia (B-ALL).

Phunzirolo, lotchedwa "Kugwiritsa Ntchito Otsatsa Kuwongolera Kuchuluka Kwambiri Pamwamba pa Mamolekyu a CAR Akhoza Kusintha Ma Kinetics a Maselo a CAR-T Mu Vivo," amafufuza momwe kusankha kwa wotsatsa kungakhudzire ntchito ya maselo a CAR-T. Ofufuza Jin-Yuan Ho, Lin Wang, Ying Liu, Min Ba, Junfang Yang, Xian Zhang, Dandan Chen, Peihua Lu, ndi Jianqiang Li ochokera ku Hebei Senlang Biotechnology ndi Chipatala cha Lu Daopei ndi omwe adatsogolera kafukufukuyu.

Zomwe apeza zikuwonetsa kuti kugwiritsa ntchito MND (myeloproliferative sarcoma virus MPSV enhancer, negative control region NCR deletion, d1587rev primer binding site replacement) m'maselo a CAR-T kumabweretsa kutsika kwa mamolekyu a CAR, omwe amachepetsa kupanga ma cytokine. Izi ndizofunikira chifukwa zimathandiza kuchepetsa zotsatira zoyipa zomwe nthawi zambiri zimagwirizanitsidwa ndi chithandizo cha CAR-T, monga cytokine release syndrome (CRS) ndi CAR-T cell-related encephalopathy syndrome (CRES).

Chiyeso chachipatala, cholembetsedwa pansi pa chizindikiritso cha ClinicalTrials.gov NCT03840317, chinaphatikizapo odwala 14 omwe adagawidwa m'magulu awiri: wina akulandira ma cell a CAR-T oyendetsedwa ndi MND ndipo winayo akulandira ma cell a CAR-T oyendetsedwa ndi EF1A. Chodabwitsa n'chakuti, odwala onse omwe amathandizidwa ndi maselo a CAR-T oyendetsedwa ndi MND adapeza chikhululukiro chonse, ndipo ambiri a iwo amasonyeza kuti alibe matenda otsalira pambuyo pa mwezi woyamba. Kafukufukuyu adawonetsanso kuchepa kwa CRS ndi CRES yovuta kwambiri kwa odwala omwe amathandizidwa ndi maselo a CAR-T oyendetsedwa ndi MND poyerekeza ndi omwe amathandizidwa ndi maselo oyendetsedwa ndi EF1A.

Dr. Peihua Lu wochokera ku chipatala cha Lu Daopei anasonyeza kuti ali ndi chiyembekezo chokhudzana ndi kuthekera kwa njira yatsopanoyi, ponena kuti, "Kugwirizana kwathu ndi Hebei Senlang Biotechnology kwapereka zidziwitso zofunika kwambiri pakukonzekera chithandizo cha CAR-T cell.

Kafukufukuyu adathandizidwa ndi thandizo lochokera ku Natural Science Foundation ya Province la Hebei ndi dipatimenti ya Sayansi ndi Ukadaulo wa Chigawo cha Hebei. Ikuwonetsa kufunikira kwa kusankha kolimbikitsa pakupanga chithandizo cha ma cell a CAR-T ndikutsegula njira zatsopano zochizira khansa yotetezeka komanso yothandiza kwambiri.