Isu Lokukhuthaza Elisha Lithuthukisa Ukuphepha Nokusebenza Kahle Kokwelashwa Kwe-CAR-T Ku-Acute B Cell Leukemia
IBeijing, eShayina – Julayi 23, 2024 – Entuthukweni entsha, iSibhedlela iLu Daopei, ngokubambisana neHebei Senlang Biotechnology, sembule imiphumela ethembisayo evela ocwaningweni lwabo lwakamuva mayelana nokwelashwa kwamaseli e-chimeric antigen receptor T (CAR-T). Lolu cwaningo, olugxile ekusebenzeni kahle nasekuphepheni kwamaseli e-CAR-T aklanywe ngabagqugquzeli abahlukene, lubonisa intuthuko enkulu ekwelapheni i-relapse noma i-refractory acute B cell leukemia (B-ALL).
Lolu cwaningo, olunesihloko esithi "Ukusetshenziswa Komthuthukisi Okulawula Ubuningi Bomphezulu We-CAR Molecules Kungase Kushintshe I-Kinetics Yamaseli E-CAR-T E-Vivo," luhlola ukuthi ukukhetha umthuthukisi kungathonya kanjani ukusebenza kwamaseli e-CAR-T. Abacwaningi uJin-Yuan Ho, uLin Wang, uYing Liu, uMin Ba, uJunfang Yang, uXian Zhang, uDandan Chen, uPeihua Lu, noJianqiang Li abavela eHebei Senlang Biotechnology naseLu Daopei Hospital bahola lolu cwaningo.
Okutholakele kwabo kubonisa ukuthi ukusebenzisa i-MND (myeloproliferative sarcoma virus MPSV enhancer, negative control region NCR deletion, d1587rev primer binding site replacement) kumaseli e-CAR-T kuholela ekubunjweni okuphansi kwama-molecule e-CAR, okunciphisa ukukhiqizwa kwe-cytokine. Lokhu kubalulekile ngoba kusiza ekunciphiseni imiphumela emibi evame ukuhlotshaniswa nokwelashwa kwe-CAR-T, njenge-cytokine release syndrome (CRS) kanye ne-CAR-T cell-related encephalopathy syndrome (CRES).
Isivivinyo somtholampilo, esibhaliswe ngaphansi kwesihlonzi se-ClinicalTrials.gov i-NCT03840317, sasihlanganisa iziguli ezingu-14 ezihlukaniswe ngamaqembu amabili: elilodwa elamukela amaseli e-CAR-T aqhutshwa yi-MND kanye nelinye elamukela amaseli e-CAR-T aqhutshwa yi-EF1A. Okuphawulekayo ukuthi zonke iziguli ezelashwe ngamaseli e-CAR-T aqhutshwa yi-MND zithole ukuthethelelwa okuphelele, kanti iningi lazo libonisa isimo esincane sokungaguli kahle ngemva kwenyanga yokuqala. Ucwaningo luphinde lwabika ukwanda okuphansi kwe-CRS kanye ne-CRES ezigulini ezelashwe ngamaseli e-CAR-T aqhutshwa yi-MND uma kuqhathaniswa nalezo ezelashwe ngamaseli aqhutshwa yi-EF1A.
UDkt. Peihua Lu waseLu Daopei Hospital uzwakalise ithemba mayelana nekhono lale ndlela entsha, ethi, "Ukubambisana kwethu neHebei Senlang Biotechnology kuveze ukuqonda okubalulekile ekwenzeni ngcono ukwelashwa kwamaseli e-CAR-T. Ngokulungisa umgqugquzeli, singathuthukisa iphrofayili yokuphepha yokwelashwa ngenkathi sigcina ukusebenza kwayo. Lesi yisinyathelo esibalulekile sokwenza ukwelashwa kwe-CAR-T kutholakale kalula futhi kubekezeleleke ezigulini."
Lolu cwaningo lusekelwe yizibonelelo ezivela kwi-Natural Science Foundation yeSifundazwe saseHebei kanye noMnyango Wezesayensi Nobuchwepheshe weSifundazwe saseHebei. Luqokomisa ukubaluleka kokukhethwa kwabagqugquzeli ekuthuthukisweni kwezindlela zokwelapha zamaseli e-CAR-T futhi luvula izindlela ezintsha zokuphepha nokusebenza kangcono. Ukwelashwa Komdlavuzas.