Izindaba
Ukwelapha Okusha Kwe-CAR-T Ku-B-cell Acute Lymphoblastic Leukemia Kubonisa Ukusebenza Okungakaze Kubonwe Ngaphambili
Ucwaningo oluqavile luqokomisa ukusebenza kahle okumangalisayo kokwelashwa kwamaseli e-CAR-T ekwelapheni i-B-cell Acute Lymphoblastic Leukemia (B-ALL). Ucwaningo, oluhilela ukubambisana ne-BIOOCUS kanye ne-Lu Daopei Hospital, lubonisa intuthuko ebalulekile, lubeka ukwelashwa njengendlela yokwelapha ebalulekile.
Ukwelashwa Kwamaseli E-CAR-T Okusha Kuguqula Ukwelashwa Kwezifo Ezimbi Zamaseli E-B
Abacwaningi baseLu Daopei Hospital kanye nabalingani bamazwe ngamazwe bahlola izindlela zokwelapha ze-CAR-T cell ezisezingeni eliphezulu, benikeza ithemba ezigulini ezine-B cell monoancies. Lolu cwaningo luqokomisa intuthuko ekwakhiweni nasekusetshenzisweni, lubonisa imiphumela ethembisayo kanye namathuba okusha esikhathini esizayo.
Ukusebenza Okuthuthukisiwe Kokulwa Nokuqubuka Kwamaseli E-CD19 CAR-T Asekelwe Ku-4-1BB Ekwelapheni I-B-ALL
Izifundo zemitholampilo zakamuva zembula ukuthi amaseli e-CD19 CAR-T asekelwe ku-4-1BB abonisa ukusebenza kahle okuphezulu kokulwa nomdlavuza uma kuqhathaniswa namaseli e-CAR-T asekelwe ku-CD28 ekwelapheni i-acute lymphoblastic leukemia (r/r B-ALL) ephinde yabuya noma engaphikisi.
Ukwelashwa kwe-CD19 CAR-T kweSibhedlela iLu Daopei okune-Dose Ephansi Kubonisa Imiphumela Ethembisayo Ezigulini ze-B-ALL
Ucwaningo lwakamuva eSibhedlela iLu Daopei lubonise ukusebenza kahle nokuphepha okuphezulu kokwelashwa kwamaseli e-CD19 CAR-T ngemithamo ephansi ekwelapheni iziguli ze-B acute lymphoblastic leukemia (B-ALL) eziphinde zagula noma eziphinde zagula. Ucwaningo, olwaluhlanganisa iziguli ezingu-51, lubonise izinga elimangalisayo lokuphulukiswa okuphelele kanye nemiphumela emibi emincane.
Isu Lokukhuthaza Elisha Lithuthukisa Ukuphepha Nokusebenza Kahle Kokwelashwa Kwe-CAR-T Ku-Acute B Cell Leukemia
Isibhedlela iLu Daopei kanye neHebei Senlang Biotechnology bamemezele imiphumela ethembisayo evela ocwaningweni lwabo lwakamuva mayelana nokuphepha nokusebenza kahle kokwelashwa kwe-CAR-T kwe-B cell leukemia ebukhali. Lokhu kubambisana kugqamisa amandla emiklamo emisha yamaseli e-CAR-T yokuthuthukisa imiphumela yeziguli.
Ucwaningo Oluphumelelayo Lubonisa Ukuphepha Nokusebenza Kahle Kokwelashwa Kwe-CAR-T Ekwelapheni Ukulimala Kwamaseli E-B
Ucwaningo olusha oluholwa nguDkt. Zhi-tao Ying wasePeking University Cancer Hospital lubonise ukuphepha nokusebenza kahle kokwelashwa kwamaseli e-IM19 CAR-T ekwelapheni umdlavuza we-B-cell ophinde wabuyela emuva futhi ongasasebenzi. Kushicilelwe ku- Ijenali YaseShayina Yezidakamizwa Ezintsha, ucwaningo lubika ukuthi iziguli ezingu-11 kwezingu-12 zithole ukuphulukiswa okuphelele ngaphandle kwemiphumela emibi kakhulu, okubonisa amandla e-IM19 njengendlela yokwelapha ethembisayo yeziguli ezinezinye izindlela ezilinganiselwe.
Intuthuko Ethuthukisiwe Kumaseli Okubulala Ngokwemvelo (NK) Eminyakeni Engaphezu Kwengu-50
Eminyakeni engamashumi amahlanu edlule, ucwaningo ngamaseli e-Natural Killer (NK) lushintshe ukuqonda kwethu ngokuzivikela komzimba okungokwemvelo, lunikeza izindlela ezintsha ezithembisayo zokwelapha umdlavuza kanye negciwane.
Ukuqeqeshwa Kwaminyaka Yonke Kokuphathwa Kwegazi Kwezokwelapha Nobuchwepheshe Bokufakelwa Kwegazi Okubanjelwe Esibhedlela iYanda Ludaopei
Ukuqeqeshwa Kwaminyaka Yonke Kwango-2024 Kokuphathwa Kwegazi Emtholampilo kanye Nobuchwepheshe Bokudluliswa Kwegazi eSanhe City kuqhutshwe ngempumelelo eSibhedlela iYanda Ludaopei. Lo mcimbi uhlose ukuthuthukisa ukuphathwa kwegazi emtholampilo kanye nokuphepha kokudluliswa kwegazi ngezifundo ezibanzi ezihanjelwe ochwepheshe bezempilo abangaphezu kwe-100 abavela ezikhungweni ezahlukene zezokwelapha.
Ukuphumelela Kwesifo Sokuzivikela Kwezingane Ezizimele: Ukwelashwa Kwamaseli e-CAR-T Kwelapha Isiguli Se-Lupus
Ucwaningo oluqavile e-Erlangen University Hospital lwelapha ngempumelelo intombazane eneminyaka engu-16 ubudala ene-systemic lupus erythematosus (SLE) enzima kusetshenziswa ukwelashwa ngamaseli e-CAR-T. Lokhu kuphawula ukusetshenziswa kokuqala kwalokhu kwelashwa kwe-lupus yabantwana, okunikeza ithemba elisha ezinganeni ezinezifo ezizimele.
Ukuthuthukisa Ukusebenza Kahle Kwe-PROTAC: Ucwaningo Oluqabulayo
Ucwaningo lwakamuva ku-Nature Communications lwembula ukuqonda okubalulekile ngezindlela zokubonisana zangaphakathi ezilawula ukusebenza kahle kokuwohloka kwamaprotheni okuqondiwe kusetshenziswa ama-PROTAC. Lokhu kutholakala kungavula indlela yokwelashwa okuphumelelayo kakhulu komdlavuza nezinye izifo.
Ukukhuthaza Impilo Nokululama: Ukunakekelwa Kwansuku Zonke Kweziguli Ezine-Leukemia
Ukuqinisekisa ukuthi iziguli ezine-leukemia zithola ukwelashwa okuphephile nokukhululekile kuhilela ukunakekelwa kwansuku zonke ngokucophelela, okuhlanganisa ukuhlanzeka kwemvelo, inhlanzeko yomuntu siqu, ukudla okunempilo, kanye nokuzivocavoca okufanele. Lo mhlahlandlela unikeza amathiphu abalulekile okunakekelwa kwansuku zonke okuphumelelayo ukusekela ukululama.
Ukwelashwa Kwamaseli e-NS7CAR-T Kubonisa Isithembiso Sokwelapha i-R/R T-ALL/LBL
Ucwaningo lwamuva nje luqokomisa ukusebenza kahle nokuphepha kokwelashwa kwamaseli e-NS7CAR-T ekwelapheni i-T-cell acute lymphoblastic leukemia (R/R T-ALL) ephinde yabuya noma engaphikisiwe kanye ne-T-cell lymphoblastic lymphoma (R/R T-LBL). Lokhu kwelashwa kunikeza ithemba elisha ezigulini ezinalezi zinhlobo zomdlavuza ezinolaka.