Nkhani
Kuyambitsa Chithandizo cha CAR-T mu B-cell Acute Lymphoblastic Leukemia Kukuwonetsa Kugwira Ntchito Kosayerekezeka
Kafukufuku wodabwitsa akuwonetsa kugwira ntchito kodabwitsa kwa chithandizo cha maselo a CAR-T pochiza B-cell Acute Lymphoblastic Leukemia (B-ALL). Kafukufukuyu, wokhudza mgwirizano ndi BIOOCUS ndi Lu Daopei Hospital, akuwonetsa kupita patsogolo kwakukulu, zomwe zakhazikitsa chithandizochi ngati njira yofunika kwambiri yochizira.
Mankhwala Atsopano a CAR-T Cell Amasintha Chithandizo cha Matenda a B Cell
Ofufuza ochokera ku Chipatala cha Lu Daopei ndi ogwira nawo ntchito padziko lonse lapansi akufufuza njira zamakono zochizira maselo a CAR-T, zomwe zikupereka chiyembekezo kwa odwala omwe ali ndi khansa ya maselo a B. Kafukufukuyu akuwonetsa kupita patsogolo kwa kapangidwe ndi kagwiritsidwe ntchito, akuwonetsa zotsatira zabwino komanso kuthekera kwa zatsopano zamtsogolo.
Kugwira Ntchito Kwambiri kwa Maselo a CD19 CAR-T Okhala ndi 4-1BB Pochiza B-ALL
Kafukufuku waposachedwapa wasonyeza kuti maselo a CD19 CAR-T okhala ndi 4-1BB amasonyeza mphamvu yolimbana ndi chotupa poyerekeza ndi maselo a CAR-T okhala ndi CD28 pochiza khansa ya m'magazi ya B cell yomwe yabwereranso kapena yokana (r/r B-ALL).
Chithandizo cha Lu Daopei cha CD19 CAR-T Chochepa Chikuwonetsa Zotsatira Zabwino mwa Odwala a B-ALL
Kafukufuku waposachedwapa ku Lu Daopei Hospital wasonyeza kuti chithandizo cha maselo a CD19 CAR-T ochepa ndi chothandiza kwambiri pochiza odwala a B acute lymphoblastic leukemia (B-ALL) omwe ali ndi vuto la khansa ya m'magazi (refractory) kapena omwe abwereranso m'thupi. Kafukufukuyu, womwe unaphatikizapo odwala 51, adawonetsa kuchuluka kwa kuchira kwathunthu komwe sikunabweretse zotsatirapo zoyipa zambiri.
Njira Yotsatsira Novel Imawonjezera Chitetezo ndi Kugwira Ntchito kwa Chithandizo cha CAR-T mu Khansa ya M'magazi ya Acute B Cell
Chipatala cha Lu Daopei ndi Hebei Senlang Biotechnology alengeza zomwe apeza kuchokera ku kafukufuku wawo waposachedwa wokhudza chitetezo ndi kugwira ntchito bwino kwa chithandizo cha CAR-T cha khansa ya m'magazi ya B cell. Mgwirizanowu uku ukuwonetsa kuthekera kwa mapangidwe atsopano a maselo a CAR-T kuti apititse patsogolo zotsatira za odwala.
Kafukufuku Wopambana Akuwonetsa Chitetezo ndi Kugwira Ntchito kwa Chithandizo cha CAR-T Pochiza Matenda a B-Cell
Kafukufuku watsopano wotsogozedwa ndi Dr. Zhi-tao Ying wochokera ku Peking University Cancer Hospital wasonyeza chitetezo ndi mphamvu ya chithandizo cha maselo a IM19 CAR-T pochiza khansa ya m'magazi ya B-cell yomwe yabwereranso komanso yosagwirizana ndi matendawa. Yofalitsidwa mu Nyuzipepala ya Mankhwala Atsopano ku ChinaKafukufukuyu akuti odwala 11 mwa 12 adachira kwathunthu popanda zotsatirapo zoyipa kwambiri, zomwe zikuwonetsa kuthekera kwa IM19 ngati njira yabwino yothandizira odwala omwe ali ndi njira zina zochepa.
Kupita Patsogolo kwa Maselo Opha Zachilengedwe (NK) Kwa Zaka Zoposa 50
Kwa zaka makumi asanu zapitazi, kafukufuku wokhudza maselo a Natural Killer (NK) wasintha kwambiri kumvetsetsa kwathu chitetezo chamthupi, zomwe zatipatsa njira zatsopano zodalirika zochiritsira khansa ndi mavairasi.
Maphunziro a Pachaka Okhudza Kusamalira Magazi ndi Ukadaulo Woika Magazi Omwe Amachitika ku Chipatala cha Yanda Ludaopei
Maphunziro a Chaka ndi Chaka a 2024 Okhudza Kusamalira Magazi ndi Ukadaulo Woika Magazi ku Sanhe City adachitika bwino ku Chipatala cha Yanda Ludaopei. Cholinga cha mwambowu ndi kulimbikitsa kayendetsedwe ka magazi m'chipatala komanso chitetezo cha magazi kudzera m'maphunziro athunthu omwe amapezeka ndi akatswiri azaumoyo oposa 100 ochokera m'mabungwe osiyanasiyana azachipatala.
Kupita Patsogolo kwa Matenda Odziteteza ku Matenda a Ana: Chithandizo cha Maselo a CAR-T Chimachiritsa Wodwala wa Lupus
Kafukufuku woyambirira ku Chipatala cha Erlangen University Hospital adathandiza bwino mtsikana wazaka 16 yemwe anali ndi matenda oopsa a systemic lupus erythematosus (SLE) pogwiritsa ntchito CAR-T cell therapy. Ichi ndi chiyambi choyamba cha kugwiritsa ntchito mankhwalawa pa ana a lupus, zomwe zikupereka chiyembekezo chatsopano kwa ana omwe ali ndi matenda odziteteza okha.
Kupititsa patsogolo Kugwira Ntchito kwa PROTAC: Kafukufuku Woyambitsa Chidwi
Kafukufuku waposachedwa mu Nature Communications akuwonetsa mfundo zazikulu za njira zolumikizirana zomwe zimathandizira kuchepetsa mphamvu ya kuwonongeka kwa mapuloteni pogwiritsa ntchito PROTACs. Kupeza kumeneku kungathandize kupeza njira yothandiza kwambiri yochizira khansa ndi matenda ena.
Kulimbikitsa Thanzi ndi Kuchira: Chisamaliro cha Tsiku ndi Tsiku cha Odwala Khansa ya M'magazi
Kuonetsetsa kuti odwala a khansa ya m'magazi akupeza chithandizo chotetezeka komanso chomasuka kumafuna chisamaliro chapadera cha tsiku ndi tsiku, kuphatikizapo ukhondo wa chilengedwe, ukhondo waumwini, zakudya zoyenera, komanso kuchita masewera olimbitsa thupi oyenera. Bukuli limapereka malangizo ofunikira kuti munthu azitha kuchira bwino tsiku ndi tsiku.
Chithandizo cha Maselo a NS7CAR-T Chikuwonetsa Lonjezo Lochiza R/R T-ALL/LBL
Kafukufuku waposachedwapa akuwonetsa mphamvu ndi chitetezo cha chithandizo cha maselo a NS7CAR-T pochiza khansa ya m'magazi ya T-cell yobwereranso kapena yokana matenda (R/R T-ALL) ndi khansa ya m'magazi ya T-cell lymphoblastic (R/R T-LBL). Chithandizochi chimapereka chiyembekezo chatsopano kwa odwala omwe ali ndi mitundu iyi ya khansa.