Chithandizo cha Maselo a NS7CAR-T Chikuwonetsa Lonjezo Lochiza R/R T-ALL/LBL

Buku laposachedwapa lomwe linafalitsidwa mu magazini ya Blood lawonetsa chidwi chachikulu pa kuthekera kwa chithandizo cha maselo a NS7CAR-T pochiza khansa ya m'magazi ya T-cell yomwe yabwereranso kapena yokana (R/R T-ALL) ndi khansa ya m'magazi ya T-cell lymphoblastic (R/R T-LBL). Kafukufukuyu, wochitidwa ngati mayeso azachipatala a gawo loyamba (ClinicalTrials.gov: NCT04572308), adawunika chitetezo ndi mphamvu ya chithandizo chatsopanochi.

Kuyesaku kunaphatikizapo odwala omwe ali ndi R/R T-ALL/LBL omwe adalandira maselo a NS7CAR-T. Zotsatira zake zinasonyeza kuti chithandizo cha NS7CAR-T sichinali chotetezeka kokha komanso chinawonetsa mphamvu yolimbana ndi chotupa. Odwala omwe adalandira maselo a NS7CAR-T anasonyeza mayankho akuluakulu azachipatala, zomwe zikusonyeza kuti chithandizochi ndi champhamvu polimbana ndi khansa yovutayi.

Ofufuza omwe achita kafukufukuyu akuphatikizapo gulu la akatswiri ochokera ku Hebei Yanda Lu Daopei Hospital ndi Hebei Senlang Biotechnology Co., Ltd. Zomwe apeza zikusonyeza kuti maselo a NS7CAR-T amatha kupangidwa bwino popanda kusintha majini ena kuti alepheretse kufalikira kwa CD7, kuchepetsa njira yopangira komanso kukulitsa luso la mankhwalawa.

Kupita patsogolo kumeneku mu chithandizo cha maselo a NS7CAR-T kukugwirizana ndi khama lomwe likupitilira popanga chithandizo chogwira mtima cha T-ALL ndi T-LBL. Kampani yathu ikupitanso patsogolo m'munda uno ndi kampani yathu yapadera. Zamalonda za CAR-T, zomwe tikukhulupirira kuti zithandizana ndi zotsatira zabwino zomwe zapezeka ndi chithandizo cha NS7CAR-T.

Zotsatira zolimbikitsa za kafukufukuyu zikutsegulira njira yopitira patsogolo kafukufuku ndi mayesero azachipatala kuti alimbikitse ntchito ya maselo a NS7CAR-T pochiza khansa ya T yomwe yabwereranso kapena yosagwira ntchito. Pamene deta yochulukirapo ikupezeka, tikukhulupirira kuti chithandizochi chidzakhala njira yodziwika bwino kwa odwala omwe akulimbana ndi matenda oopsawa.