He pai te rongoā a te NS7CAR-T Cell Therapy mō te R/R T-ALL/LBL

Nā tētahi whakaputanga hou i roto i te puka Blood, kua aro nui ki te kaha o te rongoā pūtau NS7CAR-T hei rongoā i te mate leukemia lymphoblastic acute pūtau-T kua hoki mai, kua uaua rānei te rongoā (R/R T-ALL) me te lymphoma lymphoblastic pūtau-T (R/R T-LBL). I arotakehia e te rangahau, i whakahaerehia hei whakamātautau haumanu wāhanga 1 (ClinicalTrials.gov: NCT04572308), te haumaru me te whai huatanga o tēnei maimoatanga auaha.

I whakaurua ki te whakamātautau ngā tūroro he R/R T-ALL/LBL ā rātou pūtau NS7CAR-T. I whakaatuhia e ngā hua he haumaru te rongoā NS7CAR-T, engari he kaha whakaharahara hoki ki te ārai i te pukupuku. I whakaatuhia e ngā tūroro i rongoatia ki ngā pūtau NS7CAR-T he urupare haumanu nui, e whakaatu ana i te kaha o tēnei rongoā hei taputapu kaha ki te whawhai ki ēnei mate pukupuku uaua.

Kei roto i ngā kairangahau o te rangahau tētahi rōpū tohunga mai i te Hōhipera o Hebei Yanda Lu Daopei me te Hebei Senlang Biotechnology Co., Ltd. E whakaatu ana ā rātou kitenga ka taea te whakaputa pai i ngā pūtau NS7CAR-T me te kore he whakarerekētanga ira tāpiri hei aukati i te whakaaturanga CD7, hei whakahaere i te tukanga whakaputa me te whakarei ake i te whai huatanga o te rongoā.

Ko tēnei whanaketanga i roto i te rongoā pūtau NS7CAR-T e hangai ana ki ngā mahi tonu ki te whakawhanake i ngā maimoatanga whai hua ake mō te T-ALL me te T-LBL. Kei te ahu whakamua hoki tā mātou kamupene i roto i tēnei mara me tā mātou ake Hua CAR-T, e whakapono ana mātou ka tautoko i ngā hua whakamīharo i kitea me te rongoā NS7CAR-T.

Mā ngā hua whakatenatena o tēnei rangahau ka ara ake ngā rangahau me ngā whakamātautau haumanu hei whakaū i te mahi a ngā pūtau NS7CAR-T ki te rongoā i ngā mate pukupuku pūtau-T kua hoki mai anō, kua uaua rānei te rongoā. I te mea ka nui ake ngā raraunga e wātea ana, e tūmanakohia ana ka noho tēnei rongoā hei whiringa paerewa mō ngā tūroro e whawhai ana ki ēnei mate kino.